A5031756052- melanin and skin pigmentation
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Skin Protection and Aging
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Plant and Fungal Interactions Research
- Effects of Environmental Stressors on Livestock
- Circular RNAs in diseases
- Biochemical Analysis and Sensing Techniques
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- RNA regulation and disease
- MicroRNA in disease regulation
- Microbial Metabolism and Applications
Chongqing Academy of Animal Science
2016-2025
Chongqing University
2016-2025
Long noncoding RNAs (lncRNAs) play roles in almost all biological processes; however, their function and profile skin development pigmentation is less understood. In addition, because lncRNAs are species-specific, goats has not been established. We systematically identified 100-day-old fetal by deep RNA-sequencing using the Youzhou dark goat (dark skin) Yudong white (white as a model of pigmentation. A total 841,895,634 clean reads were obtained from six libraries (samples). 1336 specific...
Objective: The study was conducted to identify the molecular mechanism of phenotype formation Youzhou black sheep by histological cytology and transcriptomics. Materials Methods: In this study, HE IHC staining were used explore patterns cytological differences in skin pigment deposition between Dark goats Banjiao goats. addition, DEGs related identified via transcriptomic analyses. Finally, expression pattern agouti signal protein (ASIP) gene from individuals with different color phenotypes...
This study aimed to investigate the significant single nucleotide polymorphisms (SNPs) and genes associated with nine reproduction morphological traits in three breed populations of Chinese goats.The genome-wide association (litter size, nipple number, wattle, skin color, coat black dorsal line, beard, beard length, hind leg hair) were analyzed native goat breeds (n = 336) using an Illumina Goat SNP50 Beadchip.A total 17 or chromosome-wide SNPs one trait size) six (wattle, identified breeds,...
MicroRNAs (miRNAs) are highly conserved, short non-coding RNAs that regulate gene expression at the posttranscriptional level. Although many miRNAs identified in muscles and muscle cells, their individual roles still not fully understood. In present study, we investigated a highly-expressed miRNA, miR-127-3p, C2C12 myoblasts tissues of goats with different phenotypes (Boer vs Wushan black goats). Our results demonstrated i) miR-127-3p was extensively expressed goats; ii) higher muscle,...
The Youzhou dark goat is a natural mutant with skin over the whole body including visible mucous membranes. In present study, we characterized 100-day-old fetal at histomorphological and transcriptomic levels in dark-skinned (Youzhou goat) white-skinned (Yudong white goats deep RNA sequencing, quantitative PCR, histological methods. Histological analysis indicated that there were marked differences both melanin distribution epidermal ultrastructure between hyperpigmented normal two breeds of...
Abstract Hu sheep is characterized by its excellent fecundity and high adaptability to various ecological environments. To reveal the molecular basis involved in sheep, we first examined 10 index of neuroendocrine metabolism blood during non‐stress period (April–May) stress (July–August) using ELISA, including CRH, adrenocorticotropic hormone (ACTH), cortisol, aldosterone, adrenaline, T3,T4, SOD, GSH‐PX, T‐AOC. Then conducted Whole genome DNA methylation sequencing performed comparative...
ABSTRACT Although specific genes have been found to be associated with skin pigmentation, the global gene expression profile for early stage of pigmentation and development in mammals is still not well understood. Here we reported a rare natural group goat (Youzhou dark goat) featuring body including visible mucous membranes, which may an exclusive kind large mammalian species this special phenotype so far. In present study, characterized 100-day-old fetal transcriptome hyperpigmented...
Abstract Background Youzhou dark goat is a rare indigenous breed that features its two outstanding characters including the skin with white coat hair and excellent adaptability to hygrothermal environment. Elucidation of mechanisms domestication selection for these traits on genome-wide level would greatly benefit medical agricultural production. In present study, we first de novo assembled characterized reference genome Illumina HiSeqX platform. Then identified variation, signatures...