A5075133363- Oceanographic and Atmospheric Processes
- Climate variability and models
- Ocean Waves and Remote Sensing
- Virus-based gene therapy research
- Arctic and Antarctic ice dynamics
- Respiratory viral infections research
- Influenza Virus Research Studies
- Animal Nutrition and Physiology
- Genetic and phenotypic traits in livestock
- Smart Grid and Power Systems
- Energy Load and Power Forecasting
- CRISPR and Genetic Engineering
- Oil Spill Detection and Mitigation
- Marine and coastal ecosystems
- Power System Optimization and Stability
- Viral-associated cancers and disorders
- Genetic Mapping and Diversity in Plants and Animals
- Monetary Policy and Economic Impact
- SARS-CoV-2 and COVID-19 Research
- Power Systems and Technologies
- High-Voltage Power Transmission Systems
- Corporate Finance and Governance
- Islanding Detection in Power Systems
- Electric Power System Optimization
- Environmental Changes in China
China University of Petroleum, Beijing
2025
Sichuan University
2024
Xiamen University
2017-2024
Shandong Marine Resource and Environment Research Institute
2014-2024
National Marine Data and Information Service
2014-2024
Anhui Provincial Children's Hospital
2022-2024
Shaoxing People's Hospital
2024
Zhejiang Chinese Medical University
2024
Shanghai University
2009-2024
Guizhou Electric Power Design and Research Institute
2018-2023
Remarkable progress has been made in developing intramuscular vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, they are limited with respect to eliciting local immunity the tract, which is primary infection site for SARS-CoV-2. To overcome limitations of vaccines, we constructed a nasal vaccine candidate based on an influenza vector by inserting gene encoding receptor-binding domain (RBD) spike protein SARS-CoV-2, named CA4-dNS1-nCoV-RBD (dNS1-RBD). A...
Uncovering genetic variation through resequencing is limited by the fact that only sequences with similarity to reference genome are examined. Reference genomes often incomplete and cannot represent full range of diversity as a result geographical divergence independent demographic events. To more comprehensively characterize pigs ( Sus scrofa ), we generated de novo assemblies nine geographically phenotypically representative from Eurasia. By comparing them pig assembly, uncovered...
Abstract Antitumor therapies based on adoptively transferred T cells or oncolytic viruses have made significant progress in recent years, but the limited efficiency of their infiltration into solid tumors makes it difficult to achieve desired antitumor effects when used alone. In this study, an virus (rVSV-LCMVG) that is not prone induce virus-neutralizing antibodies was designed and combined with cells. By transforming immunosuppressive tumor microenvironment immunosensitive one, B16...
A cross-lineage therapeutic antibody potently targets the receptor binding site of influenza B virus via multiple mechanisms.
Abstract Background Species living at high altitude are subject to strong selective pressures due inhospitable environments (e.g., hypoxia, low temperature, solar radiation, and lack of biological production), making these species valuable models for comparative analyses local adaptation. Studies that have examined high-altitude adaptation identified a vast array rapidly evolving genes characterize the dramatic phenotypic changes in animals. However, how environment shapes gene expression...
Epstein-Barr virus (EBV) infects more than 90% of the world's adult population and accounts for a significant cancer burden epithelial B cell origins. Glycoprotein (gB) is primary fusogen essential EBV entry into host cells. Here, we isolated two gB-specific neutralizing antibodies, 3A3 3A5; both effectively neutralized dual-tropic infection In humanized mice, antibodies showed effective protection from EBV-induced lymphoproliferative disorders. Cryoelectron microscopy analyses identified...
Pseudorabies virus (PRV) is a major etiological agent of swine infectious diseases and responsible for significant economic losses in the industry. Recent data points to human viral encephalitis caused by PRV infection, suggesting that may be able overcome species barrier infect humans. To date, there no available therapeutic infection. Here, we report near-atomic structures A-capsid C-capsid, illustrate interaction occurs between these subunits. We show C-capsid portal complex decorated...
Converting CO2 and green hydrogen into products such as methane methanol not only has a negative carbon effect, but also stores renewable energy chemicals. This represents promising route for storage technologies. The hydrogenation of to methanol, which represent strongly exothermic reactions, are thermodynamically favored at low temperatures. However, the inherent inertness makes it difficult activate Both reactions face challenge activating temperature, so catalysts exhibiting high...
To date, research on poultry egg production performance has only been conducted within inter or intra-breed groups, while those combining both inter- and groups are lacking. Egg is known to differ markedly between Sichuan white goose (Anser cygnoides) Landes anser). In order understand the mechanism of in geese, we undertook this study. Here, 18 ovarian stromal samples from at age 145 days (3 individuals before initiation for each breed) 730 high- low during non-laying periods were collected...
ABSTRACT Background The domestic goose is an economically important and scientifically valuable waterfowl; however, a lack of high-quality genomic data has hindered research concerning its genome, genetics, breeding. As geese breeds derive from both the swan (Anser cygnoides) graylag anser), we selected female Tianfu for genome sequencing. We generated chromosome-level assembly by adopting hybrid de novo approach that combined Pacific Biosciences single-molecule real-time sequencing,...
Abstract Chronic hepatitis B (CHB) remains a major public health concern because of the inefficiency currently approved therapies in clearing surface antigen (HBsAg). Antibody‐based regimens have demonstrated potency regarding virus neutralization and HBsAg clearance. However, high dosages or frequent dosing are required for virologic control. In this study, dual‐domain‐engineered anti‐hepatitis (HBV) therapeutic antibody 73‐DY is developed that exhibits significantly improved efficacy both...
Abstract The chitosan‐Schiff base supported palladium and cobalt bimetallic complex was synthesized in a simple method characterized by Fourier‐transform infrared spectroscopy (FT‐IR), powder X‐ray diffraction (XRD), photoelectron spectra (XPS). It found that the catalyst has great activity stability coupling of acrylamide (AA) with phenyl halide. influence various catalysts, different molar ratio Co/Pd, bases, amount base, iodobenzene/AA on reaction were investigated. results showed...
Epstein-Barr virus (EBV) is closely associated with cancer, multiple sclerosis, and post-acute coronavirus disease 2019 (COVID-19) sequelae. There are currently no approved therapeutics or vaccines against EBV. It noteworthy that combining EBV glycoproteins can elicit potent neutralizing antibodies (nAbs) viral infection, suggesting possible synergistic effects. Here, we characterize three nAbs (anti-gp42 5E3, anti-gHgL 6H2, 10E4) targeting different of the gHgL-gp42 complex. Two antibody...
Abstract The global incidence rate of kidney cancer (KC) has been steadily increasing over the past 30 years. With aging population, become an escalating concern that necessitates vigilant surveillance. Nowadays, surgical intervention remains optimal therapeutic approach for cancer, while availability efficacious treatments advanced tumors limited. Oncolytic viruses, emerging form immunotherapy, have demonstrated encouraging anti‐neoplastic properties and are progressively garnering public...
Peroxisome proliferators-activated receptor (PPAR) gene family members exhibit distinct patterns of distribution in tissues and differ functions. The purpose this study is to investigate the evolutionary impacts on diversity functions PPAR regulatory differences expression patterns. 63 homology sequences genes from 31 species were collected analyzed. results showed that three isolated types may emerge twice times duplication events. conserved domains HOLI (ligand binding domain hormone...
Dysregulation of adipogenesis causes metabolic diseases, like obesity and fatty liver. Migratory birds such as geese have a high tolerance massive energy intake exhibit little pathological development. Domesticated goose breeds, derivatives the wild greyleg (Anser anser) or swan cygnoides), resembling their ancestor species. Thus, is potentially model species to study mechanisms associated with adipogenesis.Phenotypically, liver exhibited higher fat accumulation than adipose tissues during...
Oncolytic viruses are now well recognized as potential immunotherapeutic agents against cancer. However, the first FDA-approved oncolytic herpes simplex virus 1 (HSV-1), T-VEC, showed limited benefits in some patients clinical trials. Thus, identification of novel that can strengthen therapy is warranted. Here, we identified a live-attenuated swine pseudorabies (PRV-LAV) promising agent with broad-spectrum antitumor activity vitro and vivo.PRV cytotoxicity tumor cells normal was tested using...
The interaction between water-soluble sulphonatocalix[4]arene (SC4A) and irinotecan (CPT-11) was investigated by using UV spectrophotometry. Inclusion complex of SC4A with CPT-11 confirmed 1H NMR DSC analysis. Water solubility study showed that has remarkable solubilisation on the good water solubility. antiproliferative activity evaluated. results complexation increases CPT-11.
The influenza epidemic is a huge burden to public health. Current vaccines provide limited protection against new variants due frequent mutation of the virus. continual emergence novel necessitates method rapidly monitoring virus infection in experimental systems. Although several replication-competent reporter viruses carrying fluorescent proteins or small luciferase have been generated previous studies, visualizing via such strategy requires reverse genetic modification for each viral...