A5107517383- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Ferroptosis and cancer prognosis
- Genetic and phenotypic traits in livestock
- Ovarian cancer diagnosis and treatment
- Glutathione Transferases and Polymorphisms
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Rangeland Management and Livestock Ecology
- Immune Cell Function and Interaction
- Gut microbiota and health
- Cancer-related gene regulation
- interferon and immune responses
- Adipose Tissue and Metabolism
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Cancer Immunotherapy and Biomarkers
- Liver physiology and pathology
- Immune cells in cancer
- TGF-β signaling in diseases
- Metabolomics and Mass Spectrometry Studies
- Protein Tyrosine Phosphatases
Chengdu Second People's Hospital
2025
Sun Yat-sen University
2005-2024
Sun Yat-sen University Cancer Center
2013-2024
Chongqing Academy of Chinese Materia Medica
2024
First Affiliated Hospital of GuangXi Medical University
2022-2024
Ionis Pharmaceuticals (United States)
2018-2024
Guangxi Medical University
2020-2024
Gannan Medical University
2023
Institute of Electrical and Electronics Engineers
2023
State Key Laboratory of Oncology in South China
2022-2023
Ovarian cancer is the most lethal gynecological malignancy. Timely diagnosis of ovarian difficult due to lack effective biomarkers. Laboratory tests are widely applied in clinical practice, and some have shown diagnostic prognostic relevance cancer. We aimed systematically evaluate value routine laboratory on prediction cancer, develop a robust generalisable ensemble artificial intelligence (AI) model assist identifying patients with
Abstract Background The identification of novel targets for recovering sorafenib resistance is pivotal Hepatocellular carcinoma (HCC) patients. Mitophagy the programmed degradation mitochondria, and likely involved in drug cancer cells. Here, we identified hyperactivated mitophagy essential resistance, core regulator gene ATAD3A (ATPase family AAA domain containing 3A) was down regulated hypoxia induced resistant HCC Blocking may restore sensitivity these cells provide a new treatment...
Subcellular compartmentalization has become an important theme in cell signaling such as spatial regulation of Ras by RasGRP1 and MEK/ERK Sef. Here, we report Raf kinase RKTG (Raf trapping to Golgi). is a seven-transmembrane protein localized at the Golgi apparatus. expression inhibits EGF-stimulated ERK RSK phosphorylation, blocks NGF-mediated PC12 differentiation, antagonizes Ras- Raf-1-stimulated Elk-1 transactivation. Through interaction with Raf-1, changes localization Raf-1 from...
Upon activation, TGF-β type I receptor (TβRI) undergoes active ubiquitination via recruitment of E3 ligases to the complex by Smad7. However, how TβRI is coupled intracellular trafficking, and protein degradation remains unclear. We report here that Tollip, an adaptor contains both ubiquitin-associated domains endosome-targeting domain, plays important role in modulating trafficking TβRI. Tollip was previously demonstrated possess a functional signaling interleukin-1 Toll-like receptors....
Abstract Background Species living at high altitude are subject to strong selective pressures due inhospitable environments (e.g., hypoxia, low temperature, solar radiation, and lack of biological production), making these species valuable models for comparative analyses local adaptation. Studies that have examined high-altitude adaptation identified a vast array rapidly evolving genes characterize the dramatic phenotypic changes in animals. However, how environment shapes gene expression...
Antisense oligonucleotides (ASOs) are a novel therapeutic approach to target difficult-to-drug protein classes by targeting their corresponding mRNAs. Significantly enhanced ASO activity has been achieved the targeted delivery of ASOs selected tissues. One example is hepatocytes, with N-acetylgalactosamine (GalNAc) conjugation ASO, which results in selective uptake asialoglycoprotein receptor (ASGR). Here we have evaluated potential GalNAc-conjugated as pathways hepatocellular carcinoma...
The modified Xiaoyao San (MXS) formula is an adjuvant drug recommended by the National Health Commission of China for treatment liver cancer, which has effect preventing postoperative recurrence and metastasis hepatocellular carcinoma prolonging patient survival. However, molecular mechanisms underlying that remain unclear.
Extensive and in-depth investigations of high-altitude adaptation have been carried out at the level morphology, anatomy, physiology genomics, but few focused on roles microRNA (miRNA) in adaptation. We examined differences miRNA transcriptomes two representative hypoxia-sensitive tissues (heart lung) between yak cattle, closely related species that live high low altitudes, respectively. In this study, we identified a total 808 mature miRNAs, which corresponded to 715 pre-miRNAs species. The...
The complexity of liver tumorigenesis is underscored by the recently observed anti-oncogenic effects oncoproteins, although mechanisms are unclear. Shp2/Ptpn11 a proto-oncogene in hematopoietic cells and antagonizes effect tumor suppressor Pten leukemogenesis. In contrast, we show here cooperative functions Shp2 suppressing hepatocarcinogenesis. Ablating both hepatocytes induced early-onset non-alcoholic steatohepatitis (NASH) promoted genesis tumor-initiating likely due to augmented cJun...
Yaks provide necessities such as meat and milk for Tibetans living at high altitudes on around the Qinghai-Tibetan Plateau. Enterococci are ubiquitous members of animal gut microbiota that can cause biofilm-associated opportunistic infections. Meanwhile, multidrug-resistant Enterococcus also poses a serious threat to public health. This study aims characterize antibiotic resistance, virulence genes, biofilm formation enterococci from yaks. From April 2018 July 2019, we collected 395 fecal...
Polyphenols are abundant in vegetables and fruit. They have been shown to various antitumor, antioxidant, anti-inflammatory effects. Here, we extracted the lipid-soluble fraction of polyphenols from fermented sweet potato (Ipomoea batatas). These mainly contained caffeic acid derivatives with strong antioxidant ability, which hypothesized affect diseases for oxidative stress is a factor, such as cancer. We therefore investigated antitumor chemo-sensitizing effects on E0771 murine breast...
Epithelial ovarian cancer is by far the most lethal gynecological malignancy. The exploration of promising immunomarkers to predict prognosis in patients remains challenging. In our research, we carried out an integrated bioinformatic analysis genome expressions and their immune characteristics microenvironment with validation different experiments. We filtrated 332 differentially expressed genes 10 upregulated hub from Gene Expression Omnibus database. These were closely related...
Most animals experience fasting-feeding cycles throughout their lives. It is well known that the liver plays a central role in regulating glycogen metabolism. However, how hepatic glycogenesis coordinated with cycle to control postprandial glucose homeostasis remains largely unknown. This study determines molecular mechanism underlying coupling of cycle.Through series molecular, cellular, and animal studies, we investigated PPP1R3G, glycogen-targeting regulatory subunit protein phosphatase 1...
Electric-field control of magnetization switching holds great promise for the development spintronic devices due to its intrinsically low power consumption. Here, we demonstrate efficient and reversible manipulation field-free perpendicular through electric-field driven migration oxygen ions within Pt/Co/CuOx/MoOx system. The antiferromagnetic CoO layer at Co/CuOx interface modulated by gate voltage provides an exchange bias field, enabling current-driven switching. ratio can be effectively...
Liver glycogen metabolism plays an important role in glucose homeostasis. Glycogen synthesis is mainly regulated by synthase that dephosphorylated and activated protein phosphatase 1 (PP1) combination with glycogen-targeting subunits or G subunits. There are seven (PPP1R3A to G) control glycogenesis different organs. PPP1R3G a recently discovered subunit whose expression changed along the fasting-feeding cycle proposed play postprandial In this study, we analyzed physiological function of...
The gut microbiota and its metabolic activities are crucial for maintaining host homoeostasis health, of which the role probiotics has indeed been emphasized. current study delves into performance as a beneficial managemental strategy, further highlights their impact on growth performance, serologic investigation, microbiota, profiling in yaks' calves. A field experiment was employed consisting 2 by 3 factorial controls, including two development stages, namely, 21 42 days (about one half...
Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of escape in human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC), an aggressive disease with poor response to immunotherapy pembrolizumab. depletion induces upregulation multiple type I interferon (IFN) antigen presentation machinery genes HNSCC cells. Mechanistically, binds regulates transcription UHRF1, encoding for reader H3K9me3,...
RKTG (Raf kinase trapping to Golgi) is exclusively localized at the Golgi apparatus and functions as a spatial regulator of Raf-1 by sequestrating Golgi. Based on structural similarity with adiponectin receptors, was predicted be seven-transmembrane protein cytosolic N-terminus, distinct from classical GPCRs (G-protein-coupled receptors). We analysed in detail topology functional domains this study. determined that N-terminus side. Two short stretches amino acid sequences membrane proximal...
Upon ligand binding, G-protein-coupled receptors (GPCRs) impart the signal to heterotrimeric G proteins composed of alpha, beta, and gamma subunits, leading dissociation alpha subunit from betagamma subunit. While is imperative for downstream signaling, subunit, in its own right, mediates a variety cellular responses such as GPCR desensitization via recruiting GRK plasma membrane AKT stimulation. Here we report mode spatial regulation through alteration subcellular compartmentation. RKTG...
Nonresolving inflammation is involved in the initiation and progression process of tumorigenesis. Src homology 2 domain-containing tyrosine phosphatase (SHP2) known to inhibit acute but its role chronic inflammation-associated cancer remains unclear. The SHP2 T cells dextran sulfate sodium (DSS)-induced colitis azoxymethane-DSS-induced colitis-associated carcinogenesis was examined using SHP2CD4-/- conditional knockout mice. deficiency aggravated with increased level pro-inflammatory...