A5042231020- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- interferon and immune responses
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Lung Cancer Research Studies
- Immune cells in cancer
- Chromatin Remodeling and Cancer
- Herpesvirus Infections and Treatments
- Cell death mechanisms and regulation
- Head and Neck Surgical Oncology
- Microbial infections and disease research
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Hepatitis B Virus Studies
- Oral and Maxillofacial Pathology
- Circular RNAs in diseases
- Toxoplasma gondii Research Studies
- Prostate Cancer Treatment and Research
- Cervical Cancer and HPV Research
- Hepatitis Viruses Studies and Epidemiology
- Neurosurgical Procedures and Complications
National Cancer Institute
2020-2024
University of California, San Diego
2023-2024
Center for Cancer Research
2020-2023
National Institutes of Health
2021-2022
University of Missouri–Kansas City
2015-2017
Centre Hospitalier Universitaire de Besançon
1997-2003
Hôpital Saint-Jacques
2001
Jewish Hospital
1959
Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of escape in human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC), an aggressive disease with poor response to immunotherapy pembrolizumab. depletion induces upregulation multiple type I interferon (IFN) antigen presentation machinery genes HNSCC cells. Mechanistically, binds regulates transcription UHRF1, encoding for reader H3K9me3,...
Objectives We characterize functional outcomes in head and neck cancer of unknown primary (CUP) based on site identification. Methods In this retrospective study, CUP cases were categorized as known primaries (KP) if a tumor was localized after diagnostic workup or persisting (UP). Age, sex, HPV status, methods, treatments regimens collected. Pretreatment short‐term posttreatment (3–6 months completion treatment) weights, PHQ‐9, Eating Assessment Tool (EAT‐10), Voice Handicap Index (VHI‐10)...
Abstract We have recently shown that staurosporine (ST) can trigger apoptosis of CaSki and HeLa cervical tumor cells from G2/M checkpoint, though the mechanism remains elusive. In this study, we reported ST induced inhibition E6 E7 viral oncogene MDM2 expression, while it led to increased levels p53, which was transiently located mitochondria. Additionally, proteins p53‐regulated genes, p21 WAF1 Bax, were with a similar time, Bcl‐2 Bcl‐X L expression lowered. Upon treatment, cytochrome c...
Squamous cell carcinoma of the head and neck (SCCHN) is a malignancy with poor outcomes, thus novel therapies are urgently needed. We recently showed that WHSC1 necessary for viability SCCHN cells through H3K36 di-methylation. Here, we report identification its substrate, histone H1, WHSC1-mediated H1.4K85 mono-methylation may enhance stemness features in cells. To identify proteins interacting cells, immunoprecipitation mass spectrometry identified H1 as WHSC1-interacting candidate. In...
Objectives a) To investigate responsiveness to exogenous catecholamines in rat endotoxin shock by studying both myocardial and vascular functional parameters, determine the relationship of these parameters with other relevant biological adrenergic pathway, such as beta-adrenergic receptors cyclic adenosine monophosphate (cAMP); b) role tumor necrosis factor (TNF)-alpha via prophylactic anti-TNF-alpha monoclonal antibody administration. Design Experimental, comparative study. Setting...
Purpose: Our purpose is to introduce the use of Farris–Tang retractor in optic nerve sheath decompression surgery.Methods: The procedure fenestration was reviewed at our tertiary care teaching hospital, including retractor.Results: Pseudotumor cerebri a syndrome increased intracranial pressure without clear cause. Surgical treatment can be effective cases which medical therapy has failed and disc swelling with visual field loss progresses. Optic surgery (ONDS) involves cutting slits or...
Prostate carcinoma is a common tumor of the older adult male. It associated with bony metastases, particularly to axial skeleton. We present two case histories; in both cases, patients had no prior history prostate carcinoma. Both cases were diagnosed CT imaging, elevated PSA, and biopsy. Additionally, they treated surgical resection hormone modulation therapy. While metastases are frequently advanced disease, can also be cause presenting symptoms. The imaging these showed classic...
Objectives To present a case report of sinonasal glomangiopericytoma (GPC) in female patient her thirties and to highlight the importance collecting pathology specimens even routine sinus surgery cases. Methods A detailing diagnosis GPC thirties, including initial presentation, treatment, follow-up, along with brief review literature. Results Pathology collected specimen revealed chronic rhinosinusitis. Immunohistochemistry was positive for SMA, beta-catenin, cyclin D1; negative STAT6, ERG,...
Abstract Human Papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is a cancer with 50% recurrence rate poor overall survival. While immunotherapy programmed-death-1 (PD-1) checkpoint inhibitors was recently approved in the first-line recurrent/metastatic setting, response rates are as low 20%. A main reason for this that majority of these tumors have CD8+ T-cell intratumoral infiltrate, rendering primary resistance to based immunotherapy. We found SET MYND Domain...
SUMMARY Cancers often display immune escape, but the mechanisms and potential for reversibility are incompletely understood. Epigenetic dysregulation has been implicated in escape of various cancer types. We have identified epigenetic modifier SET MYND-domain containing protein 3 (SMYD3) as a mediator human papilloma virus (HPV)- negative head neck squamous cell carcinoma (HNSCC), an aggressive disease with poor prognosis low response to immunotherapy pembrolizumab, programmed-death-1 (PD-1)...
Abstract Background: Head and neck squamous cell carcinoma (HNSCC) causes approximately 10,000 deaths annually in the United States, with human-papilloma-virus (HPV)-negative patients having a particularly poor prognosis. Pembrolizumab, programmed-death-1 (PD-1) antibody, was recently approved as first-line therapy for relapsed disease, however response rates are low 19%, underscoring need an improved understanding of immunotherapy resistance mechanisms. We have previously shown that...