A5069837203- Bacterial Infections and Vaccines
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Extracellular vesicles in disease
- Salmonella and Campylobacter epidemiology
- CRISPR and Genetic Engineering
- Pneumonia and Respiratory Infections
- Brucella: diagnosis, epidemiology, treatment
- Tuberculosis Research and Epidemiology
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Vibrio bacteria research studies
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Amoebic Infections and Treatments
- Cancer Genomics and Diagnostics
- Burkholderia infections and melioidosis
National Institutes of Health
2025
National Cancer Institute
2023-2024
Pasteur Institute of Iran
2011-2024
Center for Cancer Research
2023
Istituto Giannina Gaslini
2017-2022
Shahid Beheshti University of Medical Sciences
2014-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2021
Ospedale Policlinico San Martino
2016-2017
Research Institute for Endocrine Sciences
2014
Tehran University of Medical Sciences
2011-2013
Akkermansia muciniphila, as a member of the gut microbiota, has been proposed next-generation probiotic. Liver fibrosis is main determinant liver dysfunction and mortality in patients with chronic disease. In this study, we aimed to determine beneficial effects live pasteurized A. muciniphila its extracellular vesicles (EVs) on prevention fibrosis. The response hepatic stellate cells (HSCs) EVs was examined quiescent, lipopolysaccharide (LPS)-activated LX-2 cells. induced 8-week-old C57BL/6...
OPINION article Front. Microbiol., 24 August 2017Sec. Systems Microbiology Volume 8 - 2017 | https://doi.org/10.3389/fmicb.2017.01610
Abstract Inflammation plays a critical role in the promotion of hepatocyte damage and liver fibrosis. In recent years protective Akkermansia muciniphila , next-generation beneficial microbe, has been suggested for metabolic inflammatory disorders. this study, we aimed to evaluate effects live pasteurized A. its extra cellular vesicles (EVs) on markers involved fibrosis mouse model high-fat diet (HFD)/carbon tetrachloride (CCl 4 )-induced injury. Firstly, responses hepatic stellate cells...
Epithelial-to-mesenchymal transition (EMT) confers several traits to cancer cells that are required for malignant progression. Here, we report miR-27b-3p-mediated silencing of the single-strand RNA binding protein KHSRP is transforming growth factor β (TGF-β)-induced EMT in mammary gland cells. Sustained expression limits TGF-β-dependent induction factors and cell migration, whereas its knockdown untreated mimics TGF-β-induced EMT. Genome-wide sequencing analyses revealed controls (1) levels...
Abstract Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type in world associated with an overall poor prognosis. The protein methyltransferase SET MYND domain-containing 3 (SMYD3), which trimethylates H3K4, activates gene transcription enhances several oncogenic pathways, including epithelial-mesenchymal transition cycle related various types. It was also recently shown that SMYD3 overexpressed HPV-negative HNSCC, represses...
Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of escape in human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC), an aggressive disease with poor response to immunotherapy pembrolizumab. depletion induces upregulation multiple type I interferon (IFN) antigen presentation machinery genes HNSCC cells. Mechanistically, binds regulates transcription UHRF1, encoding for reader H3K9me3,...
To investigate antibiotic resistance, the occurrence and distribution of class 1 2 integrons in multidrug- resistant Staphylococcus aureus isolates from hospitals Tehran, Iran. The were examined for susceptibility to antimicrobial agents. mecA gene, detected by PCR. Integrase positive strains further analysed presence resistance gene cassettes using specific primers sequenced. Among 139 S.aureus isolates, 109 (78.4 %) 112 (80.5 considered as multidrug positive, respectively. Class internal...
The intestine is the major defensive barrier in body by having more than 60% of immune cells intestinal mucosa. aim this study was to evaluate Toll like receptor (TLR) signaling pathways and response profiles, against outer membrane vesicles (OMVs) pathogenic non-pathogenic strains Escherichia coli. Our results demonstrated that despite inducing inflammatory regulatory responses OMVs released both strains, there a remarkable difference nature severity these between two strains. Following...
Recent studies suggest that cancer cell death accompanied by organelle dysfunction might be a promising approach for therapy. The Golgi apparatus has key role in function and may initiate signaling pathways to mitigate stress and, if irreparable, start apoptosis. It been shown disassembly fragmentation under oxidative act as indicators stress-mediated through cycle arrest the G2/M phase. present study shows UV-induced reactive oxygen species (ROS) generation Ag@ZnO nanoparticles (NPs)...
Epigenetics regulate gene function without any alteration in the DNA sequence. The epigenetics represent one of most important regulators different cellular processes and have initially been developed microorganisms as a protective strategy. evaluation epigenetic mechanisms is also achieving an efficient control strategy tuberculosis (TB). TB significant epidemiological concerns human history. Despite several vivo vitro studies that evaluated modifications TB, many aspects association...
Despite the worldwide efforts made in field of HIV vaccine development, an efficient AIDS strategy is still vague. Virus-like particles (VLPs) are one introduced aspects for development since non-replicative nature VLPs, resulting from lack viral genomic RNA, makes them suitable broad applications. We have previously designed and non-infectious VLPs (mzNL4-3) by introduction a deletion mutation reverse transcriptase integrase coding regions HV-1. There evidences suggesting that effective...
Background: Obesity is a complex disorder influenced by various genetic and environmental factors.It has been shown that gut microbiota, which colonizes gastrointestinal tract, substantial role as an factor in the pathophysiology of obesity.Since composition microbiota alters with regard to different criteria, such ethnicity, geographical location, diet, lifestyle, age, gender, we aimed determine F/B ratio abundance important members, A. muciniphila, F. prausnitzii, Roseburia,...
The gastrointestinal tract (GI) is colonized by a complex microbial community of gut microbiota. Bacteroides spp. have significant roles in microbiota and they host interactions various mechanisms, including outer membrane vesicle (OMVs) production. In the present study, we extracted assessed fragilis (B. fragilis) thetaiotaomicron thetaiotaomicron) OMVs order to evaluate their possible utility for vivo studies.In this experimental extraction was performed using multiple centrifugations...
Development of an efficacious vaccine against brucellosis has been a challenge for scientists many years. At present, there is no licensed human brucellosis. To overcome this problem, currently, antigenic determinants Brucella cell wall such as Lipopolysaccharide (LPS) are considered potential candidates to develop subunit vaccines.In study, abortus LPS was used conjugation Neisseria meningitidis serogroup B outer membrane vesicle (OMV) carrier protein using carbodiimide and adipic...
Background: Neisseria meningitidis Serogroup A, is a major cause of bacterial outbreaks in Africa and the Middle East. While polysaccharide vaccines have been available for many years, these disadvantages including induction T-cell independent responses which do not induce memory responses. Objectives: Thus to overcome this problem, research outer membrane vesicle (OMV) containing PorA was extracted evaluated by biological immunological methods. Materials Methods: OMVs were with deoxycholate...