A5046659595- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Renal function and acid-base balance
- Respiratory Support and Mechanisms
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Nosocomial Infections in ICU
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Anesthesia and Sedative Agents
- Vitamin C and Antioxidants Research
- Cardiac, Anesthesia and Surgical Outcomes
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- S100 Proteins and Annexins
- Anesthesia and Neurotoxicity Research
- Hemodynamic Monitoring and Therapy
- Pharmacological Effects and Toxicity Studies
- Neonatal Respiratory Health Research
- Electrolyte and hormonal disorders
- Cardiac Arrest and Resuscitation
- Epilepsy research and treatment
- Clinical Nutrition and Gastroenterology
- Anesthesia and Pain Management
Tehran University of Medical Sciences
2016-2025
Sina Hospital
2011-2023
Mashhad University of Medical Sciences
2021
Biotechnology Research Center
2021
University of Tehran
2012-2019
Pharmaceutical Sciences Research Center
2017
Zanjan University of Medical Sciences
2012
Baqiyatallah University of Medical Sciences
2005
Shahid Beheshti University of Medical Sciences
2000
Ben Taub Hospital
1994
In acute respiratory distress syndrome (ARDS), there is extensive overproduction of free radicals to the extent that endogenous anti-oxidants are overwhelmed, permitting oxidative cell damage. The present study examined benefit anti-oxidant compound N-acetylcysteine (NAC) in management ARDS by measuring patient's intracellular glutathione (inside red blood cells) and extracellular (plasma) defense biomarkers outcome. Twenty-seven patients were recruited from intensive care unit a teaching...
Sepsis and septic shock is characterized by oxidative stress that mainly promotes systemic inflammation organ failure due to excessive free radical production depletion of antioxidant defenses. Therefore, we investigated the effect selenium administration on status, levels cytokines clinical outcomes.This study was a prospective randomized control trial (RCT) whereby patients received as sodium selenite (2 mg IV bolus followed 1.5 continuous infusion for 14 days) plus standard therapy. The...
Metformin has a potent inhibitory activity against inflammation and oxidative stress, which inevitably occur in sepsis-associated encephalopathy (SAE). The precise mechanisms underlying neuroprotective effects of metformin SAE, are still unclear. In the present work, protective effect on SAE using cecal ligation puncture (CLP) model sepsis, was assessed.
Critical illnesses associate with alteration in metabolic status. Insulin resistance and enhanced blood glucose levels occur during stressful situations, such as acute illnesses. These disturbances poor prognostic events. Intensive insulin therapy maintaining normoglycemia reduce the morbidity mortality rate critically ill patients. We aim to give an overview of current insights hyperglycemia critical A search literature was conducted using Pubmed articles English. Most recent relevant were...
Introduction: Classically, aminoglycosides are known to have low penetration into the lung tissue. So far, no study has been conducted on human adult patients evaluate amikacin concentration in epithelial lining fluid (ELF) of alveoli. Therefore, convincing data not available from perspective pharmacokinetics support fact that a dosage 20 mg/kg is sufficient treat with ventilator-associated pneumonia (VAP). Method: This was pilot measurement alveolar site action critically ill VAP who...
Background: Crocin can be utilized as an anti-inflammatory component of Saffron in diabetic macular edema (DME), which is known the most common cause vision loss patients with diabetes mellitus (DM). Although anti-vascular endothelial growth factor (VEGF) agents are non-center involving DME (NCI-DME), there no consensus on NCI-DME treatment. Methods: This before-after study was performed from October 2019 to August 2021. Twenty-six eyes 16 type 2 DM Baghayipoor Clinic Yazd, were treated 15...
Clostridium botulinum produces the most potent bacterial toxin, toxin A (BTXA), which has various therapeutic and cosmetic indications. Intragastric BTXA injection is a new obesity treatment method that was argued to be safe due inactivation of through liver or metabolization within gastric wall. However, 36-year-old woman admitted intensive care unit (ICU) developing botulism as result an intragastric BTXA. The diplopia, headaches, ptosis, decreased muscle force, respiratory distress two...
To investigate the effect of 6-gingerol, active component Zingiber officinale (Shēngjiāng), on sepsis-induced inflammation, oxidative injury, and organ damage in vivo. 6-gingerol was extracted from ginger, its identity confirmed with 1H NMR, 13C TLC. Sepsis induced via cecal ligation puncture (CLP) all groups except for sham. Thirty male Wistar rats were randomly divided into sham, CLP alone, ginger extract, hydrocortisone, solvent. Treatments administered intraperitoneally a dose 25 mg/kg....
Myasthenic crisis can affect the respiratory muscles in a life-limiting way that requires intubation and mechanical ventilation. This is case report of myasthenic 61-year-old woman became complicated following lack response to plasmapheresis, intravenous immunoglobulin (IVIG) therapy, development septic shock. The co-occurrence sepsis challenging condition. Many antibiotics cause flare-ups myasthenia gravis. Infection exacerbate myasthenia. We discuss successful management certain unique...
Background: Magnesium is a vital element in the body involved biochemical and physiological processes. deficiency can lead to serious consequences including cardiac, neurological, muscular disorders, other clinical manifestations. In our country, commonly, magnesium measurement done by measuring serum levels. This paper discusses prevalence of patients hospitalized ICU emphasizes importance diagnosis treating hypomagnesemia. Methods: Diagnosis hypomagnesemia magnesium, urine RBCs. We...
Background: Effective postoperative pain management, particularly in orthopedic procedures, presents significant challenges. There is increasing evidence supporting the benefits of multimodal analgesia, including use gabapentinoids and serotonin norepinephrine reuptake inhibitors (SNRIs), to minimize opioid consumption while effectively managing pain. However, a gold-standard treatment has not been established. Objectives: This study aims compare efficacy duloxetine pregabalin within...
Dyskinesia, marked by involuntary and irregular movements, can result fromvarious pharmaceutical agents. The case presented features a patient undergoingthoracotomy, experiencing dyskinesia, likely attributed to antipsychotics, antiemetics,and antibiotics, subsequently treated with amantadine.
Abstract: Chronic bronchitis is the most frequent late respiratory disease among Iranians exposed to mustard gas during Iraq‐Iran war. The aim of this study was investigate efficacy oral and intravenous corticosteroid therapy in improving lung function induced chronic patients. 65 gas‐exposed patients, who were not responsive standard treatments exacerbation occasions, randomly divided into two groups: an group (39 patients) receiving 500 mg methylprednisolone daily, (26 1 mg/kg prednisolone...
Critically ill patients under mechanical ventilation require frequent suctioning of airway secretion. Closed suction permits without disconnection from ventilator; so it might decrease hypoxemia and infection rate.This study aimed to evaluate the effect closed tracheal system (CTSS) versus open (OTSS).This is a prospective randomized study, which was carried on 100 in surgical Intensive Care Unit requiring for more than 48 hours June 2012 November 2013. In two groups, performed based...