A5018308603- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Plant chemical constituents analysis
- Sesquiterpenes and Asteraceae Studies
- Flavonoids in Medical Research
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
- Phytochemical compounds biological activities
- Traditional Chinese Medicine Analysis
- Nanoparticles: synthesis and applications
- Chemical synthesis and alkaloids
- Ginger and Zingiberaceae research
- Botanical Research and Chemistry
- Traditional and Medicinal Uses of Annonaceae
- Phytochemical and Pharmacological Studies
- Pharmacological Effects and Toxicity Studies
- Synthesis and Biological Activity
- Medicinal Plants and Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- Biochemical Analysis and Sensing Techniques
- Edible Oils Quality and Analysis
- Phytochemical Studies and Bioactivities
- Bioactive Compounds in Plants
Tehran University of Medical Sciences
2014-2025
Abstract Bio‐inspired techniques are used for synthesis in terms of application, green chemical research, facile, and eco‐friendly chemistry study silver nanostructures utilizing plant extracts as natural reducing/stabilization solid adjuvants without the use toxic damaging reagents. The present investigates biosynthesis Ag nanoparticles via mediation methanolic extract Heracleum persicum seeds, any stabilizer or surfactant. These were identified ultraviolet–visible spectroscopy, field...
Phytochemical analysis of the Ferulago trifida Boiss. from Apiaceae family led to isolation and identification suberosin (1), isoimperatorin (2), prantschimgin (3), oxypeucedanin (4), methanolate (5), suberenol (6), 6-hydroxymethylherniarin (7), hydrate (8), ulopterol (9), bergapten (10), xanthotoxin (11), imperatorin (12) grandivittin (13) chloroform extracts roots (1-9) fruits (1, 2, 8, 10-13) this species. Oxypeucedanin demonstrated a potent antioxidant power with 268.2 ± 5.4 251.2 6.2...
To investigate the effect of 6-gingerol, active component Zingiber officinale (Shēngjiāng), on sepsis-induced inflammation, oxidative injury, and organ damage in vivo. 6-gingerol was extracted from ginger, its identity confirmed with 1H NMR, 13C TLC. Sepsis induced via cecal ligation puncture (CLP) all groups except for sham. Thirty male Wistar rats were randomly divided into sham, CLP alone, ginger extract, hydrocortisone, solvent. Treatments administered intraperitoneally a dose 25 mg/kg....
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cholinergic dysfunction, neuroinflammation, oxidative stress, and memory impairment. The Salvia genus has been used since ancient times for its anti-inflammatory neuroprotective properties. In this study, we aimed to investigate the effects of aristata hydroalcoholic extract (SAHE) dichloromethane (SADE) on various aspects AD. Column chromatography was utilized in phytochemical analysis isolate purify...
From the methanolic extract of aerial parts Ajuga chamaepitys (L.) Schreb., Lamiaceae, one Iranian medicinal plants, phenylethanoid glycoside, acteoside, and two flavone glycosides, chrysoeriol 7-O-glucopyranoside (3'-methoxy-luteolin 7-O-glucopyranoside) apigenin 7-O-rhamnopyranoside, were isolated by a combination solid-phase extraction (SPE) preparative reversed-phase high-performance liquid chromatography (prep-RP-HPLC) methods. Structures compounds elucidated spectroscopic means. The...
As a result of GC and GC-MS analysis the essential oils from different parts Ferulago trifida Boiss., total thirty-three compounds were identified in flowers (Fl), stems (S), leaves (L) fruits (Fr) oils, which (E)-β-ocimene (Fl: 37.3, S: 20.7, L: 25.7, Fr: 30.5%), α-pinene 16.3, 22.6, 19.6, 18.0%) bornyl acetate 9.4, 8.5, 16.7, 11.0%) main compounds. Among thrity-eight roots oil, suberosin (20.7%), β-barbatene (6.6%) cuparene (6.1%) All exhibited weak DPPH free radical scavenging activity...
In the present study, we analyzed anti-proliferative and apoptosis induction activity of five phenolic compounds: echisoside, pleoside, chlorogenic acid, 4,5-Di-O-caffeoylquinic cynarin on AGS (adenocarcinoma gastric) cell line.These compounds were isolated from methanol extract Dorema glabrum root. An MTT assay was conducted to evaluate inhibitory effect cancer cells. EB/AO staining done assess mode death morphological changes cells' nuclei. Cell cycle distribution cells by flow cytometry,...
Background: Stachys lavandulifolia Vahl is a herbaceous plant distributed in the west and south western Asia. Despite of wide medicinal uses, there are some reports on toxicity potential this plant. In present study we attempted to evaluate characterize cytotoxic principles S. lavandulifolia. Methods: Brine shrimp lethality test (BSLT) was used general extracts essential oil obtained from aerial parts Phytochemical constituents active extract were investigated using various chromatographic...
AbstractAs a result of GC/MS and GC/FID analysis the volatile fractions obtained from leaves, bark, fruits Caucasian wingnut (Pterocarya fraxinifolia L.), 22, 31, 33 compounds were identified in which aromadendrene (26.3%), biotol (37.8%), caryophyllene (15.2%) main constituents these oils, respectively. Antioxidant activities evaluated using DPPH β-carotene/linoleic acid assays total phenolis contents extracts measured Folin–Ciocalteu method. Among extracts, bark extract had highest amount...
Background:Phlomis olivieri Benth. and Phlomis persica Boiss. (Lamiaceae) are two medicinal species endemic to Iran. In the present study, we investigated chemical compositions general toxicity potentials of essential oils obtained from aerial parts these species. Method: The plants were extracted using hydrodistillation method. CG CG-MS applied analyze constituents brine shrimp lethality test (BSLT) was used for evaluation effects oils. Results: A total 46 compounds identified in oils,...
Background: The Artemisia genus is well-known for its medicinal properties, particularly in Iranian traditional medicine. biennis, a species within this genus, widely distributed across rangelands. Objectives: This study aimed to evaluate the cytotoxic activity and chemical composition of essential oils (EO) isolated from aerial parts A. biennis Iran at different growth stages. Methods: northeast were collected during June (early vegetative stage), July (pre-flowering August (full-flowering...
Cytotoxic activity of crude extract and fractions (petroleum ether, dichloromethane, n-butanol) Artemisia haussknechtii aerial parts was investigated by MTT assay. Dichloromethane fraction showed the highest cytotoxic effect on MCF-7 cell line (IC50 = 297.17 ± 7.99 µg/mL). Phytochemical analysis most effective carried out using normal phase column chromatography (CC) to get eight sub-fractions (A-H). Thin-layer (TLC) high-performance liquid (HPLC) were used for further purification. Four...
Background: Stachys lavandulifolia Vahl is an herbaceous perennial plant which its flowering aerial parts are used traditionally as gastrotonic, spasmolytic, sedative and for the treatment of gastrointestinal disorders. In present study this medicinal was investigated flavonoid glycosides content. Methods: n-butanol fraction derived from hydroalcoholic extract S. subjected to phytochemical analysis using chromatography on Sephadex LH-20 RP-18 silica gel columns. The structures isolated...
Introduction: Asparagus officinalis L. is a medicinal plant, which contains various natural bioactive phytochemicals with potential different pharmacological activities. The present study was designed to investigate the antioxidant and antinociceptive activities of hydroalcoholic extract obtained from asparagus roots. Methods: plant material extracted using ethanol 70% preliminary phytochemical analyses were carried out. in vitro effects evaluated 1, 1-diphenyl-2-picrylhydrazyl (DPPH)...
Background: Ferulago angulata (Schltdl.) Boiss. is a herbaceous perennial plant distributed in Iran, Turkey and Iraq. The aromatic aerial parts of this are commonly used as antiseptic, sedative, wound healing, analgesic food additive. Methods: Column chromatography on silica gel (normal phase RP-18) Sephadex LH-20, along with recrystallization method were applied to isolation the phytochemicals extracted from F. fruits. structures isolated compounds characterized by 1H-NMR 13C-NMR spectral...