A5070507628- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Family and Patient Care in Intensive Care Units
- Intracerebral and Subarachnoid Hemorrhage Research
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 and healthcare impacts
- Nausea and vomiting management
- Diphtheria, Corynebacterium, and Tetanus
- Airway Management and Intubation Techniques
- Intramuscular injections and effects
- Hemodynamic Monitoring and Therapy
- Anesthesia and Neurotoxicity Research
- Renal function and acid-base balance
- Spinal Cord Injury Research
- Insurance, Mortality, Demography, Risk Management
- Vitamin C and Antioxidants Research
- Neurosurgical Procedures and Complications
Tehran University of Medical Sciences
2016-2025
Sina Hospital
2016-2025
Shariati Hospital
2015
Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis.To evaluate effects intermediate-dose vs standard-dose prophylactic anticoagulation among COVID-19 admitted intensive care unit (ICU).Multicenter randomized trial a 2 × factorial design performed 10 academic centers Iran comparing (first hypothesis) and statin therapy matching placebo (second hypothesis; not this article) adult ICU Patients...
Introduction: Classically, aminoglycosides are known to have low penetration into the lung tissue. So far, no study has been conducted on human adult patients evaluate amikacin concentration in epithelial lining fluid (ELF) of alveoli. Therefore, convincing data not available from perspective pharmacokinetics support fact that a dosage 20 mg/kg is sufficient treat with ventilator-associated pneumonia (VAP). Method: This was pilot measurement alveolar site action critically ill VAP who...
Objective: Although mechanical ventilation is frequently a life-saving therapy, its use can result in unwanted side effects. It has been well documented that the choice of sedating agent may influence duration ventilation. Melatonin sedative and analgesic without any respiratory depressant effect which makes it an attractive adjuvant for sedation intubated patients. The aim this study to evaluate melatonin on patients with hemorrhagic stroke. Methods: Forty adult stroke, who were admitted...
Myasthenic crisis can affect the respiratory muscles in a life-limiting way that requires intubation and mechanical ventilation. This is case report of myasthenic 61-year-old woman became complicated following lack response to plasmapheresis, intravenous immunoglobulin (IVIG) therapy, development septic shock. The co-occurrence sepsis challenging condition. Many antibiotics cause flare-ups myasthenia gravis. Infection exacerbate myasthenia. We discuss successful management certain unique...
Background In this study, the effect of naloxone on duration supraclavicular brachial plexus block was evaluated. It hypothesized that can increase neural blockade. Methods Sixty‐eight patients scheduled for surgery under were randomly assigned to receive 30 ml bupivacaine (Group C); with 100 μg fentanyl F); ng N); or and N + F). Sensory motor blockade recorded at 5, 15, min following block, every 10 end surgery. Duration sensory considered be time interval between complete first...
The prognostic factors of long-term outcomes in hospitalized patients with diabetes mellitus and COVID-19 are lacking. In this retrospective cohort study, we evaluated aged ≥ 18-years-old the diagnosis who were between Feb 20 Oct 29, 2020, Sina Hospital, Tehran, Iran. 1323 entered final analysis, whom 393 (29.7%) had diabetes. We followed up for incurring in-hospital death, severe COVID-19, complications, 7-month all-cause mortality. By doing univariate variables unadjusted P-value < 0.1...
Spinal cord injury is a devastating chronic condition resulting in temporary or permanent motor, sensory autonomic dysfunction of the cord. The manifestation spinal based on severity and involved areas could be different. Numerous studies have demonstrated that bradycardia, hypotension, orthostatic hypotension are present insignificant number patients after which peaks at 4th day injury. Although vasopressors common drugs been used to restore blood pressure heart rate with neurogenic shock,...
Purpose: Although the current widespread use of amikacin is in intra-abdominal sepsis treatment, its pharmacokinetic changes present setting are not yet well known. This study was aimed to evaluate profile critically ill patients with intraabdominal compared pneumosepsis. Methods: Adult septic received therapy were studied. Patients enrolled group 1 (n=16), and pneumosepsis 2 (n=13). The serum concentrations evaluated first, second, fourth sixth hours after initiating 30-minute infusion....
Key Clinical Message Generalized tetanus is still a global concern with mortality rate of up to 50%, especially in low and middle‐income countries. We reported 23‐year‐old man from Afghanistan admitted emergency department, the chief complaint generalized severe spasms lockjaw. The patient had skin lesions never been vaccinated against tetanus. He intubated intensive care unit (ICU) diagnose After receiving immunoglobulin intravenous metronidazole, combination therapy midazolam, propofol,...
Until now, April 22, 2020, Covid-19 has been confirmed in 2471136 patients and 203 countries territories with mortality rate over 169000 patients. Right there is no definite cure for it developing treatments including vaccines antiviral compounds are under evaluations efficacy. infection can be mild, severe, or even critical. The symptoms may range from fever (the most common symptom), chills, fatigue cough to decreased arterial oxygen saturation, changes respiratory dyspnea. dyspnea...
Keeping the heart rate within normal range has improved survival of septic shock patients. Amiodarone could target underlying pathophysiology sepsis-induced tachycardia. This study aimed to determine whether amiodarone is effective in controlling critically ill patients with and sustained tachycardia who were receiving vasopressor.In this prospective, single-arm cohort study, 46 enrolled receive a loading dose 150 mg, then continuous infusion 1 mg/min. The primary outcome was ability control...
Objective: Sepsis is one of the leading causes mortality in intensive care unit. Despite advances its management, rate remains high. Recently, high dose vitamin C sepsis treatment has attracted attention researchers. In current study, impacts 25 mg/kg every 6 hours as a bolus for 3 days were assessed septic patients unit (ICU).
 Methods: This was prospective cohort study that performed on adult with diagnosis sepsis. Patients assigned to control group (administration placebo) or...
Introduction: Considering that hemorrhagic stroke patients are at higher risk for bleeding, administration of doses melatonin with a controversial coagulation profile is serious concern. Objective: This study aimed to investigate the possible effects high on bleeding parameters and blood hemostasis in patients. Methods: randomized, double-blind, prospective, controlled trial. Confirmed were divided into two groups. Participants randomly assigned group (30 mg daily via gastric tube gavage 5...
Fentanyl-induced cough (FIC) is a known complication, and many studies have been conducted to prevent it. The aim of this study was evaluate the effectiveness Diphenhydramine as an antihistamine in suppressing FIC during induction anesthesia. In prospective, double-blind, randomized controlled trial, total 100 patients, ASA Class I II, scheduled for elective laparoscopy surgery were randomly assigned into two equally sized groups (n=50). diluted with distilled water 10 mg/ml. Then, patients...
Background: Intracranial hemorrhage (ICH) is a devastating condition with high mortality and morbidity rate. Neuroprotective agents protect surrounding brain tissue from the toxic effects of hematoma can result in better outcomes. There evidence demonstrating neuroprotective benefits melatonin experimental animal models ICH. Reduced levels have been reported intensive care unit (ICU) patients. The aim this study was to evaluate baseline pharmacokinetic profile ICH Methods: This randomized...
Background: Intracerebral hemorrhage (ICH) is one of the most debilitating kinds stroke. Recent evidence shows that proper initiation neuroprotective agents might save at risk neurons and improve outcome. Objectives: The focus this study to evaluate effect melatonin on patients with hemorrhagic Methods: Forty adult confirmed nontraumatic ICH, who were admitted ICU within 24 hours stroke onset enrolled in study. Subjects group received 30 mg every night for 5 consecutive nights. In order...
Background: Airway management and tracheal intubation in the ICU is a difficult procedure that may be concomitant with major complications. The purpose of this study was to evaluate effect SANYAR ® video laryngoscope(S-VL) on laryngeal view first Pass Success Intubation compared direct laryngoscopy.
 Methods: This comparative, prospective clinical conducted 120 adult patients single-center, surgical under supervision an anesthesiologist university hospital. Difficult airway predictors,...
In craniotomy surgery, it is important to maintain hemodynamics and prevent the increase of intracranial pressure. Using semi-invasive methods such as LiDCO monitoring a good option in this situation. This study aimed evaluate effectiveness mannitol hypertonic sodium on hemodynamic parameters patients undergoing elective craniotomy. randomized clinical trial was done 40 both genders. Patients whose ages were between 18-65 years, who had American Society Anesthesiologists (ASA) score I II,...
This randomized clinical trial aimed to assess and compare patient satisfaction sedation outcomes in bronchoscopy procedures using two distinct protocols: fentanyl/chlorpheniramine (FC) ketamine/chlorpheniramine (KC). Ninety patients undergoing simple bronchoalveolar lavage were randomly assigned receive either FC (1 µg/kg fentanyl 10 mg chlorpheniramine) or KC (0.5 mg/kg ketamine chlorpheniramine). Lidocaine was also administered during bronchoscopy. Primary included scores, while secondary...