Objective: Although mechanical ventilation is frequently a life-saving therapy, its use can result in unwanted side effects. It has been well documented that the choice of sedating agent may influence duration ventilation. Melatonin sedative and analgesic without any respiratory depressant effect which makes it an attractive adjuvant for sedation intubated patients. The aim this study to evaluate melatonin on patients with hemorrhagic stroke. Methods: Forty adult stroke, who were admitted...

Background: Hormone therapy is commonly used to treat breast cancer but can cause mood disorders and sleep disturbances, negatively impacting patients' well-being. Objectives: This trial aimed evaluate the effects of melatonin on problems changes in patients undergoing hormone therapy. Methods: The study was conducted at Omid Hospital Isfahan, Iran, using a randomized, double-blinded, placebo-controlled design. Participants were assessed Anxiety Depression Scale (HADS) randomly assigned...

Introduction Patients suffering from solid tumors use a wide range of cytotoxic drugs. In this study, we aimed to detect, document, and descriptively analyze the potential drug–drug interactions in hospitalized tumor’s patients Middle Eastern referral oncology–hematology University-affiliated hospital. Materials methods cross-sectional medical record who were admitted oncological center Isfahan, Iran, during six months period (2018) considered. We included all had received at least two...

Objective: Febrile neutropenia (FN) is one of the most serious clinical problems in patients with hematologic malignancies and receiving chemotherapy. The present study was implemented to determine precisely how FN managed referral hospitals Isfahan (Iran) what are characteristics as well risk factors associated development. Methods: This a cross-sectional performed over period 6 months on hospitalized Hematology-Oncology Center Omid Hospital, Isfahan, Iran. information collected by filling...

Background & aim: This trial assessed the efficacy of cotrimoxazole lock solution in reducing catheter-related blood stream infections (CRBSIs) among hemodialysis (HD) patients who were dialyzed using tunneled catheters. Method: Patients randomly received either heparin (2500 U/ml) (control group) or a mixture 10 mg/ml (based on trimethoprim) and 2500 U/ml (antibiotic as catheters solution. Results: Compared with control group, CRBSIs rates per 1000 catheter-days was significantly lower...

Cachexia is a paraneoplastic syndrome that affects the large majority of patients with end-stage cancer. No known therapy exists to effectively overcome severe symptoms cachexia, which include anorexia, weight loss and fatigue. This study considered results both experimental clinical studies evaluate suitability L-carnitine its derivatives as potential therapies for cachexia in cancer.All available English-language papers on use related cancer, including reviews, case reports, series,...

Recently published reports have suggested that antiangiogenic drugs such as sunitinib could potentiate the osteonecrosis of jaw (ONJ) induced by bisphosphonates (BPs) and even induce this adverse effect per se. We reported a case ONJ with renal cell carcinoma under medication history BPs therapy. A 53-year-old man was referred to oral surgery clinic complaining painful exposed lesion bone extraction from right lower in mouth. He underwent nephrectomy followed 5 months treatment cycles 50 mg...

Incidence of drug-drug interactions (DDIs) has been widely reported; however, such reports in pediatric oncology patients still remain scarce. We studied frequency and demographic correlates moderate major DDIs at a ward Isfahan, Iran. All admitted to the Omid hospital during 6-month period (2017) who received least 2 anticancer or non-anticancer drugs concomitantly were included our study. Potential between hospitalization was identified using Lexi-Interact on-line software. detected 194...

Background: Androgen deprivation therapy (ADT) has been considered as a mainstay of treatment for advanced prostate cancer. Considering ADT cancer patients is accompanied with many side effects, such behavioral and neurologic effects that adversely affect the quality life. Objectives: This study aimed to evaluate melatonin administration on sleep problems mood changes induced by in patients. Methods: The randomized, double-blind, placebo-controlled trial was designed oncology-hematology...

Background: Anorexia and cachexia are one of the major problems in patients suffering from advanced malignancies. Objectives: This study aimed at evaluating efficacy herbal combination containing Fenugreek, Fennel, Chicory supplementation to high-dose megestrol for treatment cancer-induced anorexia. Methods: quasi-experimental was performed on 47 adult with malignancy; they experienced anorexia weight loss over 2 past months referred a university-affiliated hospital (Omid) Isfahan, Iran....

Serum sodium (Na) concentration more than 145 mmol/L is defined as hypernatremia. Hypernatremia carries an acute morbidity and mortality, especially in neonates infants. Rapid correction of hypernatremia leads to severe cerebral damages, seizure the most common neurological complication Selection calculation appropriate fluid its amount one tremendous challenges. It important choose correct suitable adjust rehydration rate. In this study, we have suggested practical equation determine that...

Background and purpose: Cisplatin-induced nephrotoxicity (CIN) remains the most prevailing unfavorable influence may affect its clinical usage. This study sought to explore possible impacts of curcumin on preventing CIN in human subjects. Clinical design: The investigation was a placebo-controlled, double-blinded, randomized trial conducted 82 patients receiving nano-curcumin (80 mg twice daily for five days) or an identical placebo with standard nephroprotective modalities against CIN. Data...

Background: The incidence of gastric cancer is known to be high in the elderly population. Identification best perioperative chemotherapy regimen challenging patients with resectable cancer. In this study, we aimed evaluate and compare outcomes safety epirubicin, cisplatin, 5-fluorouracil (ECF), docetaxel, (DCF), oxaliplatin plus 5-Fluorouracil leucovorin (FOLFOX), oxaliplatin, leucovorin, (FLOT) regimens identify most appropriate treatment option for Materials Methods: retrospective...