A5008644439- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
- Antimicrobial Resistance in Staphylococcus
- Medication Adherence and Compliance
- SARS-CoV-2 and COVID-19 Research
- Acute Kidney Injury Research
- Long-Term Effects of COVID-19
- Trace Elements in Health
- Diverse Scientific Research Studies
- Epilepsy research and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacovigilance and Adverse Drug Reactions
- Neutropenia and Cancer Infections
- Pharmacological Effects and Toxicity Studies
- Antifungal resistance and susceptibility
- Vitamin C and Antioxidants Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Immunodeficiency and Autoimmune Disorders
- Magnesium in Health and Disease
- Aortic aneurysm repair treatments
- Prion Diseases and Protein Misfolding
- Bone and Joint Diseases
Tehran University of Medical Sciences
2015-2025
Nutrition Sciences (Belgium)
2021
Shahid Beheshti University of Medical Sciences
2021
Shariati Hospital
2021
Kermanshah University of Medical Sciences
2021
University of Isfahan
2008
The severe coronavirus disease 2019 (COVID-19) is associated with increased levels of blood interleukin (IL)-6. Therefore, it hypothesized that modulating the or effects IL-6 could diminish airway inflammation and alter course COVID-19. We conducted a controlled, randomized, double-blind clinical trial on hospitalized patients COVID-19 in Iran. were randomly distributed by block randomization to take either standard-of-care (SOC) plus 1 2 doses tocilizumab 8 mg/kg SOC alone. endpoint was...
ABSTRACT Background Invasive fungal infections (IFIs), particularly Candida infections, are a significant cause of morbidity and mortality in patients with acute leukemia. While fluconazole is widely used for prophylaxis, the optimal dosing regimen remains uncertain. This study aimed to evaluate efficacy low‐dose primary prophylaxis against invasive leukemia receiving intensive chemotherapy. Methods A double‐blind, randomized clinical trial was conducted diagnosed Patients were assigned...
Objective. The aim of our study was to assess and validate the effectiveness early dose adjustment vancomycin based on first monitoring in achieving target recommended goal critically ill patients. Methods. Twenty patients with sepsis received loading 25 mg/kg then were randomly assigned 2 groups. Group 1 maximum empirical doses 15 every 8 hrs. In group 2, individualized serum concentrations vancomycin. First nonsteady state sampling used calculate pharmacokinetic parameters within 24 hours....
Introduction: To achieve target concentrations, the application of higher-than-standard doses amikacin is proposed for treatment sepsis due to an increase in volume distribution and clearance, but little data are available on aminoglycoside administration critically ill elderly patients. Patients methods: Forty patients (aged over 65 years) who required therapy severe documented, or suspected gram-negative infections, were randomly assigned two groups. Group A (20 patients) received 15 mg/kg...
Abstract Background Coronavirus disease 2019 (COVID-19), a highly contagious viral has spread from Wuhan, Hubei Province, China to all over the world its first recognition on December 2019. To date, only few neonatal early-onset sepsis by SARS-COV-2 been reported worldwide. Case presentation In this report, we present two seriously ill neonates who were born mothers with stablished COVID-19 pneumonia. Laboratory tests showed lymphopenia high LDH and hypocalcemia right after birth. They had...
Pharmacotherapy is an essential strategy for the treatment of many medical conditions especially chronic disease and often involves multiple medications being used simultaneously. Increasing use may pose some challenges to safe effective drug therapy if not identified prevented by pharmacists eventually can lead drug-related problems (DRPs). The present study aimed examine incidence DRPs in Iranian patients evaluate patients' adherence clinical pharmacist interventions as well physicians'...
Objective: Based on previous studies in the sepsis population, Vitamin C could prevent injuries when administered high doses and before damage is established. This study aimed to evaluate protective potentials of high-dose progression coronavirus disease 2019 (COVID-19). Methods: A double-blind, placebo-controlled clinical trial was conducted. Patients with moderate-to-severe severity based World Health Organization definition were enrolled received 12 g/d (high-dose intravenous [HDIVC]) or...
<b><i>Objective:</i></b> To describe a case with Brucella-associated meningoencephalitis. In addition, we report drug-induced hepatotoxicity due to acyclovir. <b><i>Clinical Presentation and Intervention:</i></b> A young woman was admitted fever psychosis neuroimaging findings indicative of Serology positive for Brucella. She treated doxycycline, rifampin, trimethoprim-sulfamethoxazole. <b><i>Conclusion:</i></b> This...
Introduction Patients with hematologic malignancies often receive multiple medications, leading to potential drug-drug interactions (DDIs). Identifying and managing these DDIs is crucial for ensuring patient safety effective care. This study aimed identify describe associated factors in malignancy patients. Methods prospective interventional was conducted at a referral center included hospitalized patients who were receiving least four concurrent medications. A pharmacist initially compiled...
Purpose: Although the current widespread use of amikacin is in intra-abdominal sepsis treatment, its pharmacokinetic changes present setting are not yet well known. This study was aimed to evaluate profile critically ill patients with intraabdominal compared pneumosepsis. Methods: Adult septic received therapy were studied. Patients enrolled group 1 (n=16), and pneumosepsis 2 (n=13). The serum concentrations evaluated first, second, fourth sixth hours after initiating 30-minute infusion....
Abstract Background Severe COVID-19 is associated with an increased level of blood IL-6. It suggested that adjusting the IL-6 or its effects may diminish inflammation airway and alter course disease. Methods We performed a controlled, randomized, double-blind clinical trial including severe hospitalized patients in Iran. The were randomly distributed by block randomization to take usual care plus inhibitor (tocilizumab 8mg/kg, 1 2 dosages) alone (ratio 1:1). endpoint was defined improvement...
Phenytoin is an antiepileptic drug used widely for prophylaxis and treatment of seizure after neurotrauma. has a complex pharmacokinetics monitoring its serum concentrations recommended during treatment. Total phenytoin concentration routinely measured therapy. In this study, we evaluated the correlation between total free in neurotrauma critically-ill patients to determine whether reliable predictor drug, which responsible therapeutic effects.A 40 adult head trauma (unbound) concentrations....
Introduction Calcineurin inhibitors are widely used for the prevention and treatment of graft versus host disease in patients undergoing allogeneic hematopoietic stem cell transplantation, successful with calcineurin is very important management these cases. Case report A 19-year-old man thalassemia major experienced hypersensitivity reaction to parenteral vitamin K, cyclosporine, tacrolimus before transplantation. All three episodes appeared a few minutes after administration offended drugs...
<h3>Objectives</h3> Early detection of aminoglycoside-induced acute kidney injury (AKI) is crucial in intensive care unit (ICU) patients, but it not adequately reflected by serum creatinine (SrCr) levels. This study proposed investigating the relationship between amikacin trough levels and development nephrotoxicity using both conventional markers a new biomarker renal function critically ill elderly patients. <h3>Methods</h3> Thirty-three patients aged ≥65 years with normal SrCr who...
Wilson disease (WD) is an autosomal recessive disorder well recognized by the copper progressive accumulation.Copper accumulation in various organs and tissues causes toxic effects including liver, brain, kidneys eyes.Chelation therapy mainstay of treatment for patients with Wilson's disease.Chelators are naturally occurring or chemically designed molecules that bind to specific toxins body promote excretion them.Diethylenetriamine penta-acetic acid (DTPA) one well-known Chelators which used...