A5101748231- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Circular RNAs in diseases
- Fungal Biology and Applications
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Telomeres, Telomerase, and Senescence
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- SARS-CoV-2 and COVID-19 Research
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- COVID-19 Clinical Research Studies
Sun Yat-sen University
2016-2025
Children's Hospital of Fudan University
2024
Zhuhai People's Hospital
2024
Johns Hopkins University
2023
Key Laboratory of Guangdong Province
2018-2022
University of Hong Kong
2018-2019
Fifth Affiliated Hospital of Sun Yat-sen University
2019
Ministry of Education of the People's Republic of China
2019
The First Affiliated Hospital, Sun Yat-sen University
2019
Jilin University
2019
Every year, hundreds of new compounds are discovered from the metabolites marine organisms. Finding and useful is one crucial drivers for this field research. Here we describe statistics bioactive organisms 1985 to 2012. This work based on our database, which contains information more than 15,000 chemical substances including 4196 natural products. We performed a comprehensive statistical analysis understand characteristics novel detail temporal trends, structures, species distribution,...
Since the 1960s, more than 20,000 compounds were discovered from marine organisms. In this paper we performed a quantitative analysis for novel natural products reported between 1985 and 2008. The data was extracted mainly reviews of Faulkner Blunt [1-26]. organisms producing these are divided into three major biological classes: microorganisms (including phytoplankton), algae invertebrate. seven classes based on their chemical structure: terpenoids, steroids steroidal saponins), alkaloids,...
Abstract Cancer chemoresistance and metastasis are tightly associated features. However, whether they share common molecular mechanisms thus can be targeted with one strategy remain unclear in non-small cell lung cancer (NSCLC). Here, we report that high levels of microRNA-128-3p (miR-128-3p) is key to concomitant development residual NSCLC cells having survived repeated chemotherapy correlates chemoresistance, aggressiveness poor prognosis patients. Mechanistically, miR-128-3p induces...
Four new norsesquiterpene peroxides, named talaperoxides A–D (1–4), as well one known analogue, steperoxide B (5, or merulin A), have been isolated from a mangrove endophytic fungus, Talaromyces flavus. Their structures were elucidated mainly by 1D and 2D NMR. Structures of 1, 2, 5 further confirmed single-crystal X-ray diffraction, their absolute configurations also determined using copper radiation. Cytotoxic activities compounds 1–5 evaluated in vitro against human cancer cell lines...
Human coronavirus (HCoV) is one of the most common causes respiratory tract infection throughout world. To investigate epidemiological and genetic variation HCoV in Guangzhou, south China, we collected totally 13048 throat nasal swab specimens from adults children with fever acute upper symptoms Gunazhou, China between July 2010 June 2015, features its species were studied. Specimens screened for by real-time RT-PCR, 7 other viruses tested simultaneously PCR or PCR. was detected 294 cases...
Abstract Phenotypic similarities have long been recognized between subpopulations of glioma and neural stem cells. Many these similar properties, including the robust abilities to self-renew, migrate, invade, are hallmarks cells that render them extremely aggressive. However, molecular mechanisms underlying this character, particularly in stem-like drive disease, remain poorly understood. Here, we report results a differential miRNA expression screen compared cells, where found miR-204 was...
Abstract Deeper mechanistic understanding of lung adenocarcinoma (non–small cell carcinoma, or NSCLC), a leading cause cancer-related deaths overall, may lead to more effective therapeutic strategies. In analyzing NSCLC clinical specimens and lines, we discovered uniform decrease in miR-186 (MIR186) expression comparison with normal tissue epithelial lines. correlated patient survival, median overall survival time 63.0 21.5 months cases exhibiting high low levels miR-186, respectively....
Abstract Cancer stem cells (CSCs) are involved in tumorigenesis, tumour recurrence and therapy resistance Wnt signalling is essential for the development of biological traits CSCs. In non-small cell lung carcinoma (NSCLC), unlike colon cancer, mutations β-catenin APC genes uncommon; thus, mechanism underlying constitutive activation NSCLC remains unclear. Here we report that miR-582-3p expression correlates with overall- recurrence-free-survival patients, has an activating effect on...
Interferon-inducible transmembrane proteins 1, 2 and 3 (IFITM1, IFITM2 IFITM3) have recently been identified as potent antiviral effectors that function to suppress the entry of a broad range enveloped viruses modulate cellular tropism independent viral receptor expression.However, effect mechanisms IFITMs in response infections remain incompletely understood characterized.In this work, we focused our investigation on extracellular IFITM3 protein.In cell models DENV-2 infection, found...
Dengue virus (DENV) is the most common mosquito-borne infecting humans and currently a serious global health challenge. To establish infection in its host cells, DENV must subvert production and/or antiviral effects of interferon (IFN). The aim this study was to understand mechanisms by which suppresses IFN production. We determined that NS4A interacts with mitochondrial signaling protein (MAVS), previously found activate NF-κB regulatory factor 3 (IRF3), thus inducing type I...
SUMMARY Hand, foot and mouth disease (HFMD) is an infectious caused by enteroviruses, which usually occurs in children aged <5 years. In China, the HFMD situation worsening, with increasing number of cases nationwide. Therefore, monitoring predicting incidence are urgently needed to make control measures more effective. this study, we applied autoregressive integrated moving average (ARIMA) model forecast Sichuan province, China. infection data from January 2010 June 2014 were used fit...
Significance This study uncovers a long noncoding RNA (lncRNA)-mediated mechanism underlying lung adenocarcinoma (LAD) metastasis. We here report that lncRNA LINC00673-v4 expression is up-regulated in LAD and associated with disease progression. At the molecular level, acts as scaffold molecule promotes interaction between DDX3 CK1ε thus phosphorylation of dishevelled, which subsequently activates WNT/β-catenin signaling consequently causes aggressiveness LAD. Treatment antisense...
Abstract Notch signaling represents a key mechanism mediating cancer metastasis and stemness. To understand how is overactivated to couple tumor self-renewal in NSCLC cells, we performed the current study showed that RFC4, DNA replication factor amplified more than 40% of tissues, directly binds Notch1 intracellular domain (NICD1) competitively abrogate CDK8/FBXW7-mediated degradation NICD1. Moreover, RFC4 functional transcriptional target gene signaling, forming positive feedback loop...
Lack of circumcision has been identified as a risk factor for male genital human papillomavirus (HPV) infection, although this association not consistently supported.Specimens HPV testing were collected from cohort 379 (primarily heterosexual) adult males. prevalence in the glans penis and coronal sulcus, penile shaft, scrotum, semen, urine was compared by status.Overall, DNA ranged 6% semen to 52% shaft. The any infection glans/corona significantly higher uncircumcised men (46%) than...
The aims of this study were to investigate the anti-cancer activity SZ-685C, an anthracycline analogue isolated from marine-derived mangrove endophytic fungi, and explore molecular mechanisms underlying such activity.The effect SZ-685C on viability cancer cell lines was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. SZ-685C-induced apoptosis assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining, terminal deoxynucleotidyl...
Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated mangrove Aegiceras corniculatum collected in South China Sea. Their structures elucidated by one- two-dimensional NMR spectroscopy, MS data analysis circular dichroism measurements. Compounds 1, 2 3 first alterporriols a C-2–C-2′ linkage. The crystallographic tetrahydroaltersolanol B (7) was reported...
A microRNA usually has the ability to coordinately repress multiple target genes and therefore are associated with many pathological conditions such as human cancer. Our understanding of biological roles microRNAs in lung cancer, however, remains incomplete. In this study, we identified miR‐503 a tumor‐suppressive non‐small cell carcinoma (NSCLC), whose expression level correlates inversely overall survival NSCLC patients. Ectopic suppressed tumor proliferation metastasis‐related traits...
Multiple nodes in the one-carbon metabolism pathway play important regulatory roles cancer cell growth and tumorigenesis. The specific biological functions of metabolic enzymes regulating signaling pathways that are associated with tumor survival, however, remain unclear. Our current study found phosphoserine aminotransferase 1 (PSAT1), an enzyme catalyzing serine biosynthesis, was significantly up-regulated non-small lung (NSCLC) involved regulation E2F activity. Loss- gain-of-function...
MicroRNAs have been shown to contribute a repertoire of host-pathogen interactions during viral infection. Our previous study demonstrated that microRNA-30e* (miR-30e*) directly targeted the IκBα 3'-UTR and disrupted NF-κB/IκBα negative feedback loop, leading hyperactivation NF-κB. This current investigated possible role miR-30e* in regulation innate immunity associated with dengue virus (DENV) We found DENV infection could induce expression DENV-permissive cells, such an overexpression...
Zika virus (ZIKV) is a mosquito-borne that has been identified as cause of several severe disease manifestations, including congenital microcephaly and Guillain-Barré syndrome, meningoencephalitis, myelitis. Previous studies showed ZIKV-infected patients exhibited elevated plasma levels interleukin 1β (IL-1β), indicating ZIKV may activate inflammasomes. However, the molecular basis for its viral pathogenesis remains poorly understood. In this current study, we found infection caused...
Metastasis-associated in colon cancer-1 (MACC1) was first identified as a transcriptional activator for proto-oncogene c-MET expression, and its overexpression is frequently associated with metastatic progression multiply tumor types. In the present study, we analyzed time expression of MACC1 breast cancer correlation clinicopathologic features, including metastasis patient survival.MACC1 protein two cohorts clinicopathologically characterized using immunohistochemistry. Statistical analysis...
The World Health Organization (WHO) ranks respiratory tract infection (RTI) as the second leading cause of death worldwide for children under 5 years age. aim this work was to evaluate epidemiology characteristics viruses found in and adults with RTI from July 2009 June 2012 southern China.In work, a total 14 237 nasopharyngeal swabs (14 patients 25 hospitals) were analyzed, seven (influenza virus, syncytial parainfluenza adenovirus, human metapneumovirus, coronavirus, bocavirus) detected...