A5063167502- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
- Pulmonary Hypertension Research and Treatments
- Nitric Oxide and Endothelin Effects
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Medical Imaging and Pathology Studies
- Thyroid Cancer Diagnosis and Treatment
- Flavonoids in Medical Research
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Traditional Chinese Medicine Analysis
- Bone health and treatments
- Lung Cancer Research Studies
- Kruppel-like factors research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Image Segmentation Techniques
- Ion Channels and Receptors
- Ion channel regulation and function
- Vitamin D Research Studies
- Advanced Manufacturing and Logistics Optimization
- COVID-19 diagnosis using AI
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
Sun Yat-sen University
2020-2023
Southern Medical University
2022
Zhengzhou University of Light Industry
2022
Guangzhou Medical University
2022
China Pharmaceutical University
2016
Second Hospital of Liaohe Oilfield
2011-2015
Liaoning Provincial People's Hospital
2011-2015
Harbin Medical University
2008-2009
Despite the importance of AKT overactivation in tumor progression, results from clinical trials various inhibitors remain suboptimal, suggesting that AKT-driven metastasis needs to be further understood. Herein, based on long non-coding RNA (lncRNA) profiling induced by active AKT, we identify VAL (Vimentin associated lncRNA, LINC01546), which is directly AKT/STAT3 signaling, functions as a potent pro-metastatic molecule and essential for AKT-induced invasion, anoikis resistance lung...
Abstract Notch signaling represents a key mechanism mediating cancer metastasis and stemness. To understand how is overactivated to couple tumor self-renewal in NSCLC cells, we performed the current study showed that RFC4, DNA replication factor amplified more than 40% of tissues, directly binds Notch1 intracellular domain (NICD1) competitively abrogate CDK8/FBXW7-mediated degradation NICD1. Moreover, RFC4 functional transcriptional target gene signaling, forming positive feedback loop...
Abstract Aberrant activation of TGF-β signaling plays a pivotal role in cancer metastasis and progression. However, molecular mechanisms underlying the dysregulation pathway remain to be understood. Here, we found that SMAD7, direct downstream transcriptional target also key antagonist signaling, is transcriptionally suppressed lung adenocarcinoma (LAD) due DNA hypermethylation. We further identified PHF14 binds DNMT3B serves as CpG motif reader, recruiting SMAD7 gene locus, resulting...
Abstract 15‐Hydroxyeicosatetraenoic acid (15‐HETE), a product of arachidonic (AA) catalyzed by 15‐lipoxygenase (15‐LO), plays an essential role in hypoxic pulmonary arterial hypertension. We have previously shown that 15‐HETE inhibits apoptosis artery smooth muscle cells (PASMCs). To test the hypothesis such effect is attributable to hypoxia‐induced vascular remodeling (PVR), we performed these studies. found subtle thickening proximal media/adventitia arteries (PA) rats had been exposed...
The fact that dietary restriction (DR) and long-term rapamycin treatment (RALL) can ameliorate the aging process has been reported by many researchers. As interface between external genetic factors, epigenetic modification such as DNA methylation may have latent effects on rate at molecular level. To understand mechanism behind impacts of aging, gene expression changes were measured in hippocampi different-aged mice. Examining single-base resolution methylation, we discovered both maintain a...
Abstract Objective . Accurate segmentation of the pancreas from abdomen CT scans is highly desired for diagnosis and treatment follow-up pancreatic diseases. However, task challenged by large anatomical variations, low soft-tissue contrast, difficulty in acquiring a set annotated volumetric images training. To overcome these problems, we propose new network semi-supervised learning framework to alleviate lack improve accuracy segmentation. Approach. In this paper, novel graph-enhanced...
Abstract Background The exact diagnosis of double primary papillary adenocarcinoma thyroid and lung is even rarer, to our knowledge no report in the literature by [ 18 F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography/X-ray CT(FDG PET/CT) with surgical specimens immunohistochemistry(IHC). We a patient abnormal FDG PET/CT lung, this unusual presentation may lead misdiagnosis without IHC. Case A 56-year-old man coughing three months. was performed, resection were detected hematoxylin...
Selected patients with stage IV non-small cell lung cancer (NSCLC) who underwent primary tumor resection have witnessed a survival benefit. Whether additional lymph node dissection (LND) would result in better effect remain unknown. We investigated the prognostic impact of LND on NSCLC received (PTR).Patients PTR were identified from Surveillance, Epidemiology, and End Results database 2004 to 2016. Propensity-score matching was performed minimize confounding effect, cancer-specific (CSS)...
Objective To investigate the clinical values and characteristics of whole body bone imaging (SPECT/CT) in detecting metastases preoperative patients with lung adenocarcinoma or squamous cell carcinoma for staging determining best treatment plan. Methods Eighty-two primary pulmonary performed 99Tcm-MDP SPECT/CT whole-body imaging. One week before surgery, parts positive lesions MRI scan. The difference incidence metastasis was analysed by χ2 test. Results In all 82 cancer, there...