A5101467145- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Healthcare professionals’ stress and burnout
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diet, Metabolism, and Disease
- Indoor Air Quality and Microbial Exposure
- Diet and metabolism studies
- Asthma and respiratory diseases
- Ferroptosis and cancer prognosis
- Treatment of Major Depression
- Patient-Provider Communication in Healthcare
- Bioinformatics and Genomic Networks
- Functional Brain Connectivity Studies
- Gut microbiota and health
- Growth Hormone and Insulin-like Growth Factors
- CRISPR and Genetic Engineering
- Psychosomatic Disorders and Their Treatments
- Pediatric health and respiratory diseases
- Vitamin D Research Studies
- Psoriasis: Treatment and Pathogenesis
- RNA modifications and cancer
- Glutathione Transferases and Polymorphisms
- Connexins and lens biology
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024-2025
Sun Yat-sen University
2024-2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Peking Union Medical College Hospital
2011-2024
Zhejiang Chinese Medical University
2020-2024
Qingdao University
2019-2024
Suizhou Central Hospital
2024
University of South China
2013-2024
Qingdao Municipal Hospital
2024
Gut microbiota plays an essential role in the progression of nonalcoholic fatty liver disease (NAFLD), making gut-liver axis a potential therapeutic strategy. Bacteroides genus, enriched gut symbionts, has shown promise treating liver. However, further investigation is needed to identify specific beneficial strains for metabolic disorders NAFLD and elucidate their underlying mechanisms. In this study, we observed positive correlation between abundance thetaiotaomicron (B. theta) alleviation...
Early detection is vital to improve the overall survival rate of bladder cancer (BCa) patients, yet there a lack reliable urine-based assay for early BCa. Urine metabolites represented potential rich source biomarkers This study aimed develop metabolomics approach high coverage discovery and identification in urine samples. samples from 23 stage BCa patients 21 healthy volunteers with minimum sample preparations were analyzed by short 30 min UPLC-HRMS method. We detected quantified over 9000...
Metabolic associated fatty liver disease (MAFLD) is recognized as the component of metabolic syndrome, which mainly related to insulin resistance and genetic susceptibility. It most prevalent chronic worldwide. With rapid lifestyle transitions, its prevalence worldwide increasing, tremendous challenges in controlling this pandemic are arising. The objective study was investigate risk factors MAFLD rural areas Xinxiang, Henan 2017. We conducted a cross-sectional analysis inhabitants aged...
The pandemic of SARS-CoV-2 worldwide with successive emerging variants urgently calls for small-molecule oral drugs broad-spectrum antiviral activity. Here, we show that carrimycin, a new macrolide antibiotic in the clinic and an candidate phase III trials, decreases efficiency programmed –1 ribosomal frameshifting coronaviruses thus impedes viral replication fashion. Carrimycin binds directly to coronaviral frameshift-stimulatory element (FSE) RNA pseudoknot, interrupting protein...
Abstract 15‐Hydroxyeicosatetraenoic acid (15‐HETE), a product of arachidonic (AA) catalyzed by 15‐lipoxygenase (15‐LO), plays an essential role in hypoxic pulmonary arterial hypertension. We have previously shown that 15‐HETE inhibits apoptosis artery smooth muscle cells (PASMCs). To test the hypothesis such effect is attributable to hypoxia‐induced vascular remodeling (PVR), we performed these studies. found subtle thickening proximal media/adventitia arteries (PA) rats had been exposed...
Human gut microbiota can be affected by a variety of factors, including geography. This study aimed to clarify the regional specific characteristics in rural residents Xinxiang county, Henan province, with hypertension and hyperlipidemia evaluate association clinical indices. To identify microbes, 16S rRNA gene sequencing was used random forest disease classifier constructed discriminate between hypertension, hyperlipidemia, healthy control. Patients presented marked dysbiosis compared The...
Infectious spleen and kidney necrosis virus (ISKNV) is a highly virulent rapidly transmissible fish that poses threats to the aquaculture of wide variety freshwater marine fish. N6-methyladenosine (m6A), recognized as common epigenetic modification RNA, plays an important regulatory role during viral infection. However, impact m6A RNA methylation on pathogenicity ISKNV remains unexplored. Here, methylated immunoprecipitation sequencing (MeRIP-seq) coupled with (RNA-seq) was used...
Fine particulate matter (PM2.5), a ubiquitous environmental pollutant, has been indicated to affect thyroid hormone (TH) homeostasis in women, but the detailed mechanism behind this effect remains unclear. The objective of study was evaluate roles hypothalamic-pituitary-thyroid (HPT) axis and hepatic transthyretin thyroid-disrupting effects PM2.5. Sprague Dawley rats were treated with PM2.5 (0, 15 30 mg/kg) by passive pulmonary inhalation for 49 days; recovery experimental group dosed (30 35...
The evidence that exposure to ambient ozone (O3) causes acute cardiovascular effects appears inconsistent. A repeated-measure study with 61 healthy young volunteers was conducted in Xinxiang, Central China. Real-time concentrations of O3 were monitored. Cardiovascular outcomes including blood pressure (BP), heart rate (HR), serum levels high sensitivity C-reactive protein (hs-CRP), 8-hydroxy-2'-deoxyguanosine (8-OHdG), tissue-type plasminogen activator (t-PA), and platelet-monocyte...
Exposure to ambient air-borne fine particulate matter (PM2.5) increases respiratory morbidity and mortality. The mechanisms underlying PM2.5-induced adverse effects remain unclear. This study aimed uncover the molecular of lung toxicity using a mouse model. Scanning electron microscopy inductively coupled plasma mass spectrometry were used examine analyze PM2.5 morphology element compositions, respectively. Twenty four male mice randomly divided into three groups: control (PBS), (4.0 mg/kg...
PM2.5 (particulate matter ≤2.5 μm in aerodynamic diameter) is a major urban air pollutant worldwide. Its effects on the respiratory system of susceptible population have been less characterized. This study aimed to estimate association short-term exposure with outcomes retired adults, and examine whether these associations were stronger among subjects GSTT-null genotype. 32 healthy (55–77 years) recruited for five follow-up examinations. Ambient concentrations monitored consecutively 7 days...
Exposure to fine particulate matter (PM2.5) is associated with various adverse health effects, such as respiratory and cardiovascular diseases. This study aimed evaluate the association of PM2.5 neural damage biomarkers. A total 34 healthy retirees were recruited from Xinxiang Medical University December 2018 April 2019. Concentrations constituents including 24 metals nonmetallic elements 6 ions, 5 biomarkers brain-derived neurotrophic factor (BDNF), neurofilament light chain (NfL),...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic worldwide, and there no specific drug to treat it. Recent results showed that 17-beta-hydroxysteroid dehydrogenase type 13 (HSD17B13) associated with diseases, but these conclusions are controversial. Here, we HSD17B13 was more highly expressed in livers of NAFLD patients, high expression induced murine models cultural hepatocytes treated using various etiologies. The facilitated progression by directly stabilizing...
Epidemiological evidence has linked air pollution with adverse respiratory outcomes, but the mechanisms underlying susceptibility to remain unclear. This study aimed investigate role of glutathione S-transferase (GST) polymorphism in association between and lung function levels. A total 75 healthy young volunteers aged 18-20 years old were recruited for six follow-up visits examinations. Spirometry was conducted obtain parameters such as forced vital capacity (FVC), expiratory volume 1 s...
We developed an inductively coupled plasma mass spectrometry method for testing 23 elements, namely, Mg, Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, Sn, Sb, Ba, W, Tl, Pb, and U, in human serum. The serum samples were analyzed after diluting 1/25 with 0.5% nitric acid, 0.02% Triton-X-100, 2% methanol. Sc, In, Y, Tb, Bi assigned internal standards to correct the baseline drift matrix interference. kinetic energy discrimination mode of instrument helium gas as collision...
Fine particulate matter (PM2.5) is the primary environmental stressor and a significant threat to public health. However, effect of PM2.5 exposure on human nasal microbiota its pathophysiological implication remain less understood. This study aimed explore associations with indices biomarkers inflammation oxidative stress. We conducted panel 75 students in Xinxiang, Henan Province, China, from September December 2017. Biomarkers stress including interleukin-6 (IL-6), IL-8, tumor necrosis...
Nonalcoholic fatty liver disease (NAFLD), ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), is a worldwide without approved therapeutic drugs. Anti-inflammatory and hepatoprotective drug bicyclol multi-pharmacological active berberine, respectively, have shown beneficial effects on NAFLD in murine nutritional models patients, though the mechanisms remain be illustrated. Here, we investigated combined of berberine mouse induced by Western diet (WD), NASH WD/CCl4. The use...
Background It is important to maintain the psychological well-being of front-line healthcare staff during coronavirus disease 2019 (COVID-19) pandemic. Aims To examine COVID-19-related stress and its immediate impact on staff. Method All working in fever clinic, from 20 January 2020 26 March 2020, a tertiary general hospital were enrolled. Stress management procedures place alleviate concerns about respondents’ own health their families, help them adjust work provide support via hotline....