A5101914334- Healthcare professionals’ stress and burnout
- Viral Infections and Immunology Research
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Mental Health Treatment and Access
- Cellular transport and secretion
- COVID-19 Clinical Research Studies
- Phagocytosis and Immune Regulation
- Respiratory viral infections research
- Salmonella and Campylobacter epidemiology
- Cytomegalovirus and herpesvirus research
- Ubiquitin and proteasome pathways
- Rheumatoid Arthritis Research and Therapies
- Spine and Intervertebral Disc Pathology
- Optimism, Hope, and Well-being
- Health, psychology, and well-being
- vaccines and immunoinformatics approaches
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects of Natural Compounds
- Genetic Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Neurological and metabolic disorders
Xinxiang Medical University
2020-2024
Xi'an Jiaotong University
2021-2024
IQVIA (United States)
2024
Qinghai University
2024
Pudong New Area People's Hospital
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2021
Peking Union Medical College Hospital
2011-2021
Xi'an University of Architecture and Technology
2015-2020
University of Minnesota
2020
Shanghai University of Medicine and Health Sciences
2020
Abstract Neurofibrillary tangles are a pathological hallmark of Alzheimer’s disease, and their levels correlate with the severity cognitive dysfunction in humans. However, experimental evidence suggests that soluble tau species cause deficits memory impairment. Our recent study caspase-2 (Casp2)-catalyzed cleavage at aspartate 314 mediates synaptic impairment mouse cellular models neurodegenerative disorders. Δtau314, C-terminally-truncated products, present human brain. In addition, Δtau314...
The recent COVID-19 pandemic poses a global health emergency. Cellular entry of the causative agent SARS-CoV-2 is mediated by its spike protein interacting with cellular receptor-human angiotensin converting enzyme 2 (ACE2). Here, using lentivirus based pseudotypes bearing protein, we demonstrated that into host cells was dependent on clathrin-mediated endocytosis, and phosphoinositides played essential roles during this process. In addition, showed intracellular domain catalytic activity...
Background It is important to maintain the psychological well-being of front-line healthcare staff during coronavirus disease 2019 (COVID-19) pandemic. Aims To examine COVID-19-related stress and its immediate impact on staff. Method All working in fever clinic, from 20 January 2020 26 March 2020, a tertiary general hospital were enrolled. Stress management procedures place alleviate concerns about respondents’ own health their families, help them adjust work provide support via hotline....
Enterovirus 71 (EV71) is one of the major pathogens causing hand, foot, and mouth disease in children under 5 years old, which can result severe neurological complications even death. Due to limited treatments for EV71 infection, identification novel host factors elucidation mechanisms involved will help counter this viral infection. N-terminal acetyltransferase 6 (NAT6) was identified as an essential factor infection with genome-wide CRISPR/Cas9 screening. NAT6 facilitates replication...
Enteroviruses (EVs) are the main cause of a number neurological diseases. Growing evidence has revealed that successful infection with enteroviruses is highly dependent on host machinery, therefore, proteins play pivotal role in viral infections. Both and can undergo post-translational modification (PTM) which regulate protein activity, stability, solubility interactions other proteins; thereby influencing various biological processes, including cell metabolism, metabolic, signaling...
EV71 is one of the most common pathogens causing HFMD in young children, and some patients experience severe or fatal neurological consequences. To ensure efficient replication, virus must hijack multiple host factors for its own benefit.
Enterovirus 71 (EV71) is a neurotropic pathogen that causes hand, foot, and mouth disease (HFMD) it has been consistently associated with severe neurological, cardiac, respiratory complications. Yet there no specific treatment for this virus we still know little about the viral pathogenesis. In study, first generated an infectious cDNA clone of EV71 from patient strain made full-length NanoLuc reporter gene through reverse genetic approaches. The genetically stable when passaging in cells...
To assess the validity of World Health Organization-University California-Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) in diagnosis Alzheimer's disease (AD).Using WHO-UCLA AVLT, we assessed 183 AD patients (AD group),1283 subjects with normal cognitive status (normal control group), and 134 individuals suffered from other diseases easy to be confused (confused group).The AVLT score was 40.9∓0.3 group, 30.7∓0.9 16.6∓1.0 mild 10.2∓1.2 moderate group after adjustment for...
Background The COVID-19 outbreak, which was first reported in Wuhan of China December 2019, began to occur the world, involving over 200 countries now. Methods A total 37 overseas young and mid-aged people, who were tested SARS-CoV-2 positive upon their return Shanghai, enrolled for an analysis clinical symptoms, blood routine indexes lung CT images. Results symptoms characterized by fever (51.4%), dry cough (13.5%), expectoration(27.0%), hypodynamia (21.6%), pharyngalia (10.8%),...
Background: The outbreak of COVID-19 puts major psychological pressure on medical workers exposed to patients. We examined COVID-19-related stress and its immediate impact staff, provide evidence help improve the management among them. Methods: Stress procedures alleviate worries about health their own families, adjustment work, give support by hotline were carried out. Psychiatrists evaluators conducted telephone interviews with each worker at fever clinic a general hospital in Beijing from...
The association of neovascular age-related macular degeneration (nAMD), diabetic edema (DME), and retinal vein occlusion (RVO) with functional status in the general Medicare population are not well established.
Objective: We analysed our early-on psychological service to medical workers in fever clinic of a tertiary general hospital Beijing during the outbreak covid-19, so as explore how provide better help at front line.Methods: From January 20 March 28, 2020, we offered resource-oriented supportive hotline all Beijing. Following data were also acquired and analysed: basic information, qualitative interview, Impact Event Scale-Revised (IES-R), Patient Health Questionaire-9 (PHQ-9) Maslach Burn-out...
Abstract The recent COVID-19 pandemic poses a global health emergency. Cellular entry of the causative agent SARS-CoV-2 is mediated by its spike protein interacting with cellular receptor- human angiotensin converting enzyme 2 (ACE2). Here, we used lentivirus based pseudotypes bearing to demonstrate that into host cells dependent on clathrin-mediated endocytosis, and phosphoinositides play essential role during this process. In addition, showed intracellular domain catalytic activity ACE2...
Objective To explore the characteristics of psychiatric acute consultation in general hospital.Methods During 3 years (2009.07..01-2012.06.30),2789 referrals consultations were enrolled,among which 249 consultations,while others common as control group.The demographic characteristics,reasons for referral,referral department,psychiatric diagnosis according to International Statistical Classification Diseases 10th Revision,management analyzed.Results In consultations,the rate male patients...