A5058911447- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- BRCA gene mutations in cancer
- Health Systems, Economic Evaluations, Quality of Life
- Breast Cancer Treatment Studies
- Ovarian cancer diagnosis and treatment
- Influenza Virus Research Studies
- Economic and Financial Impacts of Cancer
- Endometriosis Research and Treatment
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Smoking Behavior and Cessation
- Pulmonary Hypertension Research and Treatments
- Global Health Care Issues
- Estrogen and related hormone effects
- Musculoskeletal synovial abnormalities and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Colorectal Cancer Treatments and Studies
- HIV/AIDS Research and Interventions
- Health disparities and outcomes
IQVIA (United States)
2017-2025
IQVIA (United Kingdom)
2020-2024
IQ Solutions
2023
Albert Einstein College of Medicine
2011-2018
Georgetown University Medical Center
2011-2018
Georgetown University
2010-2018
Montefiore Medical Center
2018
Harvard University
2012-2017
Dana-Farber Cancer Institute
2012-2017
Koning (United States)
2017
Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this extends to all invasive histological subtypes or borderline tumours not clear. We undertook an international collaborative study assess the association between endometriosis and of cancer.
<h3>Importance</h3> Given recent advances in screening mammography and adjuvant therapy (treatment), quantifying their separate combined effects on US breast cancer mortality reductions by molecular subtype could guide future decisions to reduce disease burden. <h3>Objective</h3> To evaluate the contributions associated with treatment based estrogen-receptor (ER) human epidermal growth factor receptor 2 (<i>ERBB2</i>, formerly<i>HER2</i>or<i>HER2/neu</i>). <h3>Design, Setting,...
Background: Controversy persists about optimal mammography screening strategies. Objective: To evaluate outcomes, taking into account advances in and treatment of breast cancer. Design: Collaboration 6 simulation models using national data on incidence, digital performance, effects, other-cause mortality. Setting: United States. Patients: Average-risk U.S. female population subgroups with varying risk, density, or comorbidity. Intervention: Eight strategies differing by age at which starts...
Molecular characterization of breast cancer allows subtype-directed interventions. Estrogen receptor (ER) is the longest-established molecular marker.We used six established population models with ER-specific input parameters on age-specific incidence, disease natural history, mammography characteristics, and treatment effects to quantify impact screening adjuvant therapy age-adjusted US mortality by ER status from 1975 2000. Outcomes included stage-shifts absolute relative reductions in...
Background: Timing of initiation screening for breast cancer is controversial in the United States. Objective: To determine threshold relative risk (RR) at which harm–benefit ratio women aged 40 to 49 years equals that biennial 50 74 years. Design: Comparative modeling study. Data Sources: Surveillance, Epidemiology, and End Results program, Breast Cancer Surveillance Consortium, medical literature. Target Population: A contemporary cohort eligible routine screening. Time Horizon: Lifetime....
Background: Biennial screening is generally recommended for average-risk women aged 50 to 74 years, but tailored may provide greater benefits. Objective: To estimate outcomes various intervals after age years based on breast density and risk cancer. Design: Collaborative simulation modeling using national incidence, density, performance data. Setting: United States. Patients: Women or older with combinations of relative (RR) 1.0, 1.3, 2.0, 4.0. Intervention: Annual, biennial, triennial...
Abstract Background: U.S. Black women have higher breast cancer mortality rates than White despite lower incidence. The aim of this study is to investigate how much the disparity can be attributed racial differences in natural history, uptake mammography screening, and use adjuvant therapy. Methods: Two simulation models common national race, age-specific data for incidence, screening treatment dissemination, stage distributions, survival, competing from 1975 2010. Treatment effectiveness...
Abstract Background The burden associated with schizophrenia is substantial. Impacts on the individual, healthcare system, and society may be particularly striking within veteran population due to presence of physical mental health comorbidities. Disease also influenced by a complex interplay between social determinants disparities. objective current study was compare non-healthcare societal outcomes veterans without in United States Veterans Health Administration (VHA). Methods A...
Seasonal influenza poses a substantial clinical and economic burden in the United States vulnerable populations, including elderly those with comorbidities, are at elevated risk for influenza-related medical complications.We conducted retrospective cohort study using IQVIA PharMetrics® Plus claims database two stages. In Stage 1, we identified patients evidence of medically-attended during seasons from October 2014 to May 31, 2018 (latest available data 1) used multivariable logistic...
Obesity-related complications (ORCs) are associated with high costs for healthcare systems. We assessed the relationship between comorbidity burden, represented by both number and type of 14 specific ORCs, total over time in people obesity USA.Adults (≥ 18 years old) identified from linked electronic medical records administrative claims databases, a body mass index measurement 30-< 70 kg/m2 1 January 2007 31 March 2012 (earliest measurement: date), continuous enrolment ≥ year pre (baseline...
Background. Since their inception in 2000, the Cancer Intervention and Surveillance Network (CISNET) breast cancer models have collaborated to use a nationally representative core of common input parameters represent key components control each model. Employment inputs permits greater ability compare model output than when begins with different parameters. The also enhances inferences about results, provides range reasonable results based on variations structure, assumptions, methods values....
Purpose Gene expression profile (GEP) testing can support chemotherapy decision making for patients with early-stage, estrogen receptor–positive, human epidermal growth factor 2–negative breast cancers. This study evaluated the cost effectiveness of one GEP test, Onco type DX (Genomic Health, Redwood City, CA), in community practice test-eligible age 40 to 79 years. Methods A simulation model compared 25-year societal incremental costs and quality-adjusted life-years (QALYs) use from 2005...
Objective To evaluate frequency, severity and costs of flares in US patients with newly diagnosed SLE. Methods Adults SLE between January 2005 December 2014 were identified from commercial claims data linked to electronic medical records. Disease flare during 1 year after diagnosis classified as mild, moderate or severe using a claims-based algorithm. Study outcomes included frequency stratified by disease the 1-year post-diagnosis period all-cause healthcare at 30, 60 90 days flare. Results...
The search for genetic variants associated with ovarian cancer risk has focused on pathways including sex steroid hormones, DNA repair, and cell cycle control. Ovarian Cancer Association Consortium (OCAC) identified 10 single-nucleotide polymorphisms (SNPs) in genes these pathways, which had been genotyped by members a pooled analysis of data was conducted. Three the SNPs showed evidence an association at P< or =0.10 log-additive model: rs2740574 CYP3A4 (P=0.011), rs1805386 LIG4 (P=0.007),...
BACKGROUND US breast cancer mortality is declining, but thousands of women still die each year. METHODS Two established simulation models examine 6 strategies that include increased screening and/or treatment or elimination obesity versus continuation current patterns. The use common national data on incidence and prevalence, competing causes death, mammography characteristics, effects, survival/cure. Parameters are modified based (defined as BMI ≥ 30 kg/m 2 ). Outcomes presented for the...
Background. The Georgetown University-Albert Einstein College of Medicine breast cancer simulation model (Model GE) has evolved over time in structure and function to reflect advances knowledge about cancer, improvements early detection treatment technology, progress computing resources. This article describes the provides examples applications. Methods. is a discrete events microsimulation single-life histories women from multiple birth cohorts. Events are simulated absence screening...
Objective To assess the economic burden of patients with SLE by disease severity in USA 1 year before and after diagnosis. Methods Patients aged ≥18 years a first diagnosis (index date) between January 2005 December 2014 were identified from administrative commercial claims data linked to electronic medical records (EMRs). Disease during was classified as mild, moderate, or severe using claims-based algorithms EMR data. Healthcare resource utilisation (HCRU) all-cause healthcare costs (2017...
Abstract Background Several epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKI) have been approved for first‐line (1L) treatment of EGFR‐mutated metastatic non‐small cell lung cancer (mNSCLC) in the United States (US). Real‐world analyses 1L patterns with EGFR TKIs, including third‐generation TKI osimertinib which was most recently 2018, are still sparse. Methods This retrospective observational study used data from IQVIA's prescription claims (LRx) and medical (Dx)...
This study examined MDD treatment regimens received during the first observed and treated major depressive episode (MDE) among US veterans.This retrospective study, conducted using Veterans Health Administration (VHA) database, supplemented with Medicare Part A/B/D data, included adults ≥1 diagnosis (index date) between 10/1/2015-2/28/2017 line of therapy (LOT) within complete MDE. Patient baseline (6-month pre-index) characteristics up to six LOTs MDE were assessed.Of 40,240 veterans...
Obesity affects multiple points along the breast cancer control continuum from prevention to screening and treatment, often in opposing directions. is also more prevalent Blacks than Whites at most ages so it might contribute observed racial disparities mortality. We use two established simulation models Cancer Intervention Surveillance Modeling Network (CISNET) evaluate impact of obesity on race-specific outcomes. The common national data inform parameters for US birth cohorts Black White...
QUESTION ASKED: Many individuals at risk for BRCA1 or BRCA2 mutations do not have access to trained genetic counselors. This study conducted an economic evaluation alongside a clinical trial of approaches extending the reach testing services geographically underserved populations. SUMMARY ANSWER: Telephone counseling was less expensive than in-person delivered in community per individual counseled, tested, mutation detected. For example, it cost average $120 (range, $80 $200) person...
Real-world data evaluating weight changes in people living with HIV (PLWH) following switch to integrase strand transfer inhibitor (INSTI), specifically bictegravir (BIC), are limited. This retrospective cohort study analyzed upon switching INSTI from non-nucleoside reverse transcriptase (NNRTI) or protease (PI) treatment-experienced PLWH.Adult PLWH (≥18 years) treated NNRTI PI (non-switch cohorts) and those (switch between January 1, 2014 August 31, 2019 were identified using IQVIA's...
IntroductionThe National Breast and Cervical Cancer Early Detection Program (NBCCEDP) provides mammograms diagnostic services for low-income, uninsured women aged 40–64 years. Mammography facilities within the NBCCEDP gradually shifted from plain-film to digital mammography. The purpose of this study is assess impact replacing film with mammography on health effects (deaths averted, life-years gained [LYG]); costs (for screening diagnostics); number reached.MethodsNBCCEDP 2010 data...
BackgroundU.S. guidelines recommend that patients with severe asthma be referred to specialists (allergists/immunologists or pulmonologists) for systematic assessment comanagement; however, contemporary, real-world data on the frequency and impact of specialist care among U.S. are lacking.ObjectivesTo quantify visits asthma, identify patient demographic clinical characteristics associated describe health outcomes following care.MethodsSevere aged 6 years older were identified between January...