A5068993336- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Genomics and Rare Diseases
- Respiratory and Cough-Related Research
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Signaling Pathways in Disease
- Genomic variations and chromosomal abnormalities
- Sphingolipid Metabolism and Signaling
- Cancer Immunotherapy and Biomarkers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Cardiac Fibrosis and Remodeling
- Atmospheric Ozone and Climate
- Congenital Ear and Nasal Anomalies
- Congenital heart defects research
- Sinusitis and nasal conditions
- Genetic Syndromes and Imprinting
- Inflammatory mediators and NSAID effects
Amgen (United States)
2021-2025
Cincinnati Children's Hospital Medical Center
2013-2024
University of Cincinnati Medical Center
2019-2024
Nationwide Children's Hospital
2023
University of Cincinnati
2011-2021
National Institute of Allergy and Infectious Diseases
2018
Indiana University – Purdue University Indianapolis
2005-2008
Medical University of South Carolina
2008
Indiana University School of Medicine
2005-2007
Augusta University
2005
Periostin was originally identified as an osteoblast-specific factor and is highly expressed in the embryonic periosteum, cardiac valves, placenta, periodontal ligament well many adult cancerous tissues. To investigate its role during development, we generated mice that lack periostin gene replaced translation start site first exon with a lacZ reporter gene. Surprisingly, although widely developing organs, periostin-deficient (peri(lacZ)) embryos are grossly normal. Postnatally, however,...
The secreted periostin protein, which marks mesenchymal cells in endocardial cushions following epithelial–mesenchymal transformation and mature valves remodeling, is a putative valvulogenesis target molecule. Indeed, expressed throughout cardiovascular morphogenesis all 4 adult mice (annulus leaflets). Additionally, the fibrous cardiac skeleton developing heart but absent from both normal and/or pathological mouse cardiomyocytes. Periostin ( peri lacZ ) knockout exhibit viable valve...
Background Kabuki syndrome (KS) is a clinically recognisable in which 70% of patients have pathogenic variant KMT2D or KDM6A . Understanding the function these genes opens door to targeted therapies. The purpose this report propose diagnostic criteria for KS, particularly when molecular genetic testing equivocal. Methods An international group experts created consensus KS. Systematic PubMed searches returned 70 peer-reviewed publications at least one individual with molecularly confirmed KS...
Many patients with severe asthma continue to experience symptoms and exacerbations despite treatment standard-of-care therapy. In the phase 3 NAVIGATOR study, tezepelumab significantly reduced over 52 weeks compared placebo in severe, uncontrolled asthma. This analysis assessed efficacy of reducing various clinically relevant subgroups NAVIGATOR. was a 3, multicentre, randomized, double-blind, placebo-controlled study. Participants (12–80 years old) were randomized 1:1 receive 210 mg or...
Candidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these been restricted to evaluations specific SNPs within a and populations from European ancestry. Recently, there is increasing interest in understanding racial differences genetic risk childhood asthma. Our aim was compare association patterns candidate genes between children African ancestry.Using custom-designed Illumina SNP array, we...
Individuals with Kabuki syndrome present immunodeficiency; however, how pathogenic variants in the gene encoding histone-modifying enzyme lysine methyltransferase 2D (KMT2D) lead to immune alterations remain poorly understood. Following up on our prior report of KMT2D-altered integrin expression B-cells, we performed targeted analyses KMT2D’s influence T-cells throughout development (thymocytes through peripheral T-cells) murine cells constitutive- and conditional-targeted Kmt2d deletion....
Abstract Background Allergic asthma is the most common phenotype among patients with severe asthma. In phase 3 NAVIGATOR study (NCT03347279), tezepelumab significantly reduced annualized exacerbation rate (AAER) versus placebo in severe, uncontrolled This exploratory analysis evaluated efficacy of participants evidence allergic Methods Patients (12–80 years old) receiving medium‐ or high‐dose inhaled corticosteroids and ≥ 1 additional controller medication, without oral corticosteroids, were...