A5100456832- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- MicroRNA in disease regulation
- Ion channel regulation and function
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Cardiac Fibrosis and Remodeling
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Aquaculture Nutrition and Growth
- Organ Transplantation Techniques and Outcomes
- Vasculitis and related conditions
- Signaling Pathways in Disease
- Growth Hormone and Insulin-like Growth Factors
- Nutrition and Health in Aging
- Peptidase Inhibition and Analysis
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Hormonal Regulation and Hypertension
- HIV-related health complications and treatments
- Acute Myocardial Infarction Research
- Renin-Angiotensin System Studies
- Ion Transport and Channel Regulation
- Neuroscience and Neural Engineering
- Ovarian function and disorders
Hunan Children's Hospital
2023-2024
Central South University
2024
Yueyang Hospital
2022
Beijing Children’s Hospital
2021-2022
Army Medical University
2017-2022
Capital Medical University
2021-2022
Shanghai University of Traditional Chinese Medicine
2022
Fujian Medical University
2022
Union Hospital
2022
Daping Hospital
2017-2021
Periostin was originally identified as an osteoblast-specific factor and is highly expressed in the embryonic periosteum, cardiac valves, placenta, periodontal ligament well many adult cancerous tissues. To investigate its role during development, we generated mice that lack periostin gene replaced translation start site first exon with a lacZ reporter gene. Surprisingly, although widely developing organs, periostin-deficient (peri(lacZ)) embryos are grossly normal. Postnatally, however,...
Chronic inflammation and malnutrition play important roles in muscle loss. Although albumin, globulin albumin to ratio (AGR) are considered be useful inflammatory-nutritional biomarkers, their relationship with mass remain unclear. This study aimed investigate the between them adults.We utilized data from National Health Nutrition Examination Survey (NHANES) 2011-2014 for analysis. Data on globulin, appendicular skeletal mass, body index (BMI) potential confounders (sociodemographic...
G protein-coupled receptor kinase 4 (GRK4) has been reported to play an important role in hypertension, but little is known about its cardiomyocytes and myocardial infarction (MI). The goal of present study explore the GRK4 pathogenesis progression MI.
As the major cause of female anovulatory infertility, polycystic ovary syndrome (PCOS) affects a great proportion women at childbearing age. Although glucagon-like peptide 1 receptor agonists (GLP-IRAs) show therapeutic effects for PCOS, its target and underlying mechanism remains elusive. In present study, we identified that, both in vivo vitro, GLP-1 functioned as regulator proliferation antiapoptosis MGCs follicle PCOS mouse ovary. Furthermore, forkhead box protein O1 (FoxO1) plays an...
Calcific aortic valve disease (CAVD), a common heart disease, is increasingly prevalent worldwide and causes high morbidity mortality. Here, we aimed to investigate possible role for miR-34c in the development of osteogenic differentiation during CAVD find out underlying mechanisms. Valvular interstitial cells (VICs) were isolated from clinical tissue samples patients with acute dissection collected. Then, RT-qPCR was performed determine expression western blot analysis applied confirm...
Objective The aim of this study was to analyze the diagnosis, treatment, and follow-up six cases complex arrhythmias associated with RYR2 gene mutations in children. Method A retrospective analysis conducted on children diagnosed mutations. included an age onset, initial symptoms, electrocardiographic characteristics, genetic results, treatment course, outcomes. Results Among study, there were four males two females, average 3.5 ± 0.5 years. time from symptoms diagnosis 2.7 1.3 most common...
The aim of the present study is to report diagnosis and treatment a rare case frequent torsades de pointes (Tdp) in child with novel AKAP9 mutation. A 13-year-old girl suffered from repeated syncope Tdp. An electrocardiogram (ECG) showed multisource premature ventricular contractions R-ON-T phenomenon. QTc ranged 410 468 ms. genetic test indicated heterozygous mutation, namely, c.11714T > C (p.M3905T), gene, which controversial gene long QT syndrome. After propranolol, recurrent occurred,...
Abstract Aims: Cardiac hypertrophy, in the long-term, is a maladaptive response to change hemodynamics needed maintain cardiac output that leads heart failure and sudden death. However, underlying regulatory mechanisms causing hypertrophy remain be elucidated. Recent studies have highlighted importance of long non-coding RNAs (lncRNAs) many biological processes diseases. knowledge role lncRNAs diseases still limited. Methods Results：We identified NPPA-AS1 remodeling. heart-enriched...