A5071942300- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Signaling Pathways in Disease
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
- Pancreatic function and diabetes
- Nitric Oxide and Endothelin Effects
- Pluripotent Stem Cells Research
- Cardiac electrophysiology and arrhythmias
- Hippo pathway signaling and YAP/TAZ
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Peptidase Inhibition and Analysis
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Neuropeptides and Animal Physiology
- Curcumin's Biomedical Applications
- Cardiomyopathy and Myosin Studies
- Renin-Angiotensin System Studies
- RNA Interference and Gene Delivery
- Congenital Heart Disease Studies
- Connexins and lens biology
- Antiplatelet Therapy and Cardiovascular Diseases
Southwest Hospital
2013-2025
Army Medical University
2015-2024
Daping Hospital
2015-2024
Chongqing University
2023-2024
Chongqing Medical University
2022
State Council of the People's Republic of China
2022
Chengdu Second People's Hospital
2022
Chongqing Science and Technology Commission
2022
Temple University
2013-2019
Center for Excellence in Molecular Cell Science
2017
Adult mammalian hearts have a limited ability to generate new cardiomyocytes. Proliferation of existing adult cardiomyocytes (ACMs) is potential source Understanding the fundamental biology ACM proliferation could be great clinical significance for treating myocardial infarction (MI). We aim understand process and regulation its role in cardiomyocyte formation post-MI mouse hearts.β-Actin-green fluorescent protein transgenic mice fate-mapping Myh6-MerCreMer-tdTomato/lacZ were used trace fate...
Mitochondrial (mt) dysfunction and oxidative stress are involved in the pathogenesis of ischemia/reperfusion (I/R)-injury. Lycopene, a lipophilic antioxidant found mainly tomatoes other vegetables fruits, can protect mtDNA against damage. However, role myocardial I/R-injury is unclear. In present study, we aimed to determine if how lycopene protects cardiomyocytes from I/R-injury. both vitro vivo studies, increased mt 8-hydroxyguanine (8-OHdG) content, decreased content transcription levels,...
Transplantation of stem cells into damaged hearts has had modest success as a treatment for ischemic heart disease. One the limitations is poor cell survival in diseased microenvironment. Prolyl hydroxylase domain protein 2 (PHD2) cellular oxygen sensor that regulates key transcription factors involved and inflammation: hypoxia-inducible factor nuclear factor-κB.We studied whether how PHD2 silencing human adipose-derived (ADSCs) enhances their cardioprotective effects after transplantation...
Abstract Curcumin exerts beneficial effects on cardiovascular diseases, including hypertension. However, its mechanisms are unknown. We propose that curcumin prevents the development of hypertension by regulating AT 1 receptor (AT R) expression in arteries. The present study examined how regulates R vascular smooth muscle cells and investigated physiological significance this regulation angiotensin (Ang) II-induced results showed decreased a concentration- time-dependent manner cells. Using...
Defining mechanisms of cardiomyocyte proliferation should guide the understanding endogenous cardiac regeneration and could lead to novel treatments for diseases such as myocardial infarction. In neonatal heart, energy metabolic reprogramming (phenotypic alteration glucose, fatty acid, amino acid metabolism) parallels cell cycle arrest cardiomyocytes. The occurring shortly after birth is associated with alterations in blood oxygen levels, substrate availability, hemodynamic stress, hormone...
After myocardial infarction (MI), the heart is difficult to repair because of great loss cardiomyoctyes and lack cardiac regeneration. Novel drug candidates that aim at reducing pathological remodeling stimulating regeneration are highly desirable. In present study, we identified if how a novel porcupine inhibitor CGX1321 influenced MI Permanent ligation left anterior descending (LAD) coronary artery was performed in mice induce injury. Cardiac function measured by echocardiography, infarct...
Antioxidants have shown great promise in stroke prevention. Diarylheptanoids (also known as diphenylheptanoids) are a small class of plant secondary metabolites that possess antioxidant activity greater than α-tocopherol. Curcumin is the best member and mainly extracted from turmeric. This study aimed to explore whether curcumin has preventive effect on stroke.Stroke-prone spontaneously hypertensive rats (SHRsp) were randomly divided into control group (n = 10) 10), saline or (100 mg/kg/day)...
Rationale: PKA (Protein Kinase A) is a major mediator of β-AR (β-adrenergic) regulation cardiac function, but other mediators have also been suggested. Reduced basal activity and activation are linked to diseases. However, how complete loss impacts on physiology if it causes dysfunction never determined. Objectives: We set determine the heart adapts cardiomyocyte elicits abnormalities. Methods Results: (1) Cardiac was almost completely inhibited by expressing inhibitor peptide in...
G protein-coupled receptor kinase 4 (GRK4) has been reported to play an important role in hypertension, but little is known about its cardiomyocytes and myocardial infarction (MI). The goal of present study explore the GRK4 pathogenesis progression MI.
Background Ischemia/reperfusion injury (IRI) is one of the most predominant complications ischemic heart disease. Gastrin has emerged as a regulator cardiovascular function, playing key protective role in hypoxia. Serum gastrin levels are increased patients with myocardial infarction, but pathophysiogical significance this finding unknown. The purpose study was to determine whether and how protects cardiac myocytes from IRI. Methods Results Adult male Sprague‐Dawley rats were used...
Abstract Hypertensive nephropathy (HN) is a common cause of end-stage renal disease with fibrosis; chronic kidney associated elevated serum gastrin. However, the relationship between gastrin and fibrosis in HN still unknown. We, now, report that mice angiotensin II (Ang II)-induced had increased cholecystokinin receptor B (CCKBR) expression. Knockout CCKBR aggravated, while long-term subcutaneous infusion ameliorated injury interstitial unilateral ureteral obstruction (UUO). The protective...
Vascular smooth muscle cells (VSMCs) proliferation and migration, which are central in the development of vascular diseases, regulated by numerous hormones humoral factors. Activation insulin receptor stimulates VSMCs while dopamine receptors, via D1 D3 inhibit stimulatory effects norepinephrine on proliferation. We hypothesize that activation D4 may also migration VSMCs, therefore, atherosclerosis. Our current study found increased A10 cells, an effect was reduced presence a agonist,...
The dopaminergic and sympathetic systems interact to regulate blood pressure. Our previous studies showed regulation of α1-adrenergic receptor function by D1-like dopamine receptors in vascular smooth muscle cells. Because renalase could circulating epinephrine levels production renal proximal tubules (RPTs), we tested the hypothesis that expression kidney. effect stimulation on was measured immortalized RPT cells from Wistar-Kyoto (WKY) spontaneously hypertensive rats (SHRs). We found...
Abstract Background/aims Liver lipid accumulation induced by high-fat diet (HFD) is an early onset process of non-alcoholic fatty liver diseases (NAFLD). Protein kinase A (PKA) known to be involved in hepatic metabolism. However, the role PKA NAFLD has not been well tested vivo due lack optimal deficient mouse model. Methods novel PKA-specific inhibitor gene was conditionally overexpressed (PKAi mouse) using LoxP/Cre system. activity extract measured with a commercial assay kit. The PKAi and...
Optical visualization of complex microstructures in the entire organ is essential for biomedical research. However, existing methods fail to accurately acquire detailed whole organs with good morphological and biochemical preservation. This study proposes a cryo-fluorescence micro-optical sectioning tomography (cryo-fMOST) image three dimensions (3D) submicron resolution. The system comprises line-illumination microscope module, cryo-microtome, three-stage refrigeration heat insulation...