A5101866930- HIV Research and Treatment
- interferon and immune responses
- Nitric Oxide and Endothelin Effects
- Viral Infections and Outbreaks Research
- Receptor Mechanisms and Signaling
- Phytochemicals and Antioxidant Activities
- Ion Transport and Channel Regulation
- Virus-based gene therapy research
- Hormonal Regulation and Hypertension
- Plant Pathogens and Fungal Diseases
- Mosquito-borne diseases and control
- Galectins and Cancer Biology
- Cytomegalovirus and herpesvirus research
- Plant-Microbe Interactions and Immunity
- Eicosanoids and Hypertension Pharmacology
- T-cell and Retrovirus Studies
- Phytoestrogen effects and research
- HIV/AIDS drug development and treatment
- Diet, Metabolism, and Disease
- Genomics, phytochemicals, and oxidative stress
- Animal Disease Management and Epidemiology
- Renin-Angiotensin System Studies
- Essential Oils and Antimicrobial Activity
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
Yibin Vocational and Technical College
2023-2025
Harbin Veterinary Research Institute
2014-2025
Chinese Academy of Agricultural Sciences
2014-2025
Yibin University
2023-2025
People's Hospital of Bishan District
2024
First Affiliated Hospital of Dalian Medical University
2016-2024
Chongqing Medical University
2024
Dalian Medical University
2016-2024
Huazhong Agricultural University
2018-2021
Heilongjiang Bayi Agricultural University
2014-2019
The present study investigated the anti-obesity and anti-diabetic effects of kaempferol glycoside (KG) fractions which were composed four glycosides purified from unripe Jindai-soybean (Edamame) leaves in C57BL/6J mice. High fat-fed mice treated with 0.15% dietary KG for 92 days had reduced body weight, adipose tissue TG levels compared to high control group. KG-treatment also decreased fasting blood glucose, serum HbA1c (hemoglobin A(1c)) improved insulin resistance. Gene expression...
The primate lentiviral accessory protein Nef downregulates CD4 and major histocompatibility complex class I (MHC-I) from the cell surface via independent endosomal trafficking pathways to promote viral pathogenesis. In addition, antagonizes a novel restriction factor, SERINC5 (Ser5), increase infectivity. To explore molecular mechanism of Ser5 antagonism by Nef, we determined how affects expression intracellular in comparison MHC-I. We confirm that excludes human immunodeficiency virus type...
Abstract Membrane‐associated RING‐CH (MARCH) family proteins were recently reported to inhibit viral replication through multiple modes. Previous work showed that human MARCH8 blocked Ebola virus (EBOV) glycoprotein (GP) maturation. Our study here demonstrates MARCH1 and MARCH2 share a similar pattern in restricting EBOV GP‐pseudotyped infection. Human retain GP at the trans ‐Golgi network, reduce its cell surface display, impair virions infectivity. Furthermore, we uncover host proprotein...
Smallpox is a highly contagious human disease caused by the variola virus. Although was eliminated in 1979 due to its nature and historical pathogenicity, with mortality rate of up 30%, this virus an important candidate for biological weapons. Currently, vaccines are critical measures prevent infection spread. In study, we designed peptide vaccine using immunoinformatics tools, which have potential activate immunity against efficiently. The design peptides derives from vaccine-candidate...
Abstract Local adaptation is critical in speciation and evolution, yet comprehensive studies on proximate ultimate causes of local are generally scarce. Here, we integrated field ecological experiments, genome sequencing, genetic verification to demonstrate both driving forces molecular mechanisms governing body coloration a lizard from the Qinghai-Tibet Plateau. We found dark lizards cold meadow population had lower spectrum reflectance but higher melanin contents than light counterparts...
Membrane-associated RING-CH-type 8 (MARCH8) strongly blocks human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) incorporation into virions by downregulating its cell surface expression, but the mechanism is still unclear. We now report that MARCH8 also Ebola (EBOV) (GP) via downregulation. To understand how these viral fusion proteins are downregulated, we investigated effects of on EBOV GP maturation and externalization conventional secretion pathway. interacted with...
Abstract Glycitein is an isoflavone that reportedly inhibits the proliferation of human breast cancer and prostate cells. However, its anti‐cancer molecular mechanisms in gastric remain to be defined. This study evaluated antitumor effects glycitein on cells investigated underlying mechanisms. We used MTT assay, flow cytometry western blotting investigate with focus reactive oxygen species (ROS) production. Our results showed had significant cytotoxic markedly decreased mitochondrial...
ABSTRACT Ser ine inc orporator 5 ( SER INC5, SER5) suppresses viral cell-free infection. However, its antiviral potency under cell-cell infection is not examined yet. Here, we established the in vitro systems to assess SER5’s activity on HIV-1 and bovine leukemia virus (BLV). Our results showed SER5 from different mammalian species, including Homo sapiens , Bos taurus Felis catus was capable of significantly inhibiting these SER5s were unable restrict Intriguingly, Ebola...
We investigated the effects of a mixture daidzin and glycitin, which are glycoside-form isoflavones daidzein glycitein, respectively, on body weight, lipid levels, diabetic markers, metabolism in high-fat diet (HF) fed C57BL/6J mice for 92 days. The were divided into basic group (CON), HF group, companied with isoflavone (HFISO). Results showed that HFISO had significantly lower weight adipose tissue compared to group. Blood glucose, serum HbA1c, insulin also levels In addition, higher...
Glycosylated Gag (glycoGag) is an accessory protein expressed by most gammaretroviruses, including murine leukemia virus (MLV). MLV glycoGag not only enhances replication and disease progression but also increases human immunodeficiency type 1 (HIV-1) infectivity as Nef does. Recently, SERINC5 (Ser5) was identified the target for Nef, Nef-like activity has been attributed to Ser5 antagonism. Here, we investigated how antagonizes using glycoMA proteins. We confirm previous observations that...
Bovine leukemia virus (BLV) causes enzootic bovine leukosis in cattle and leads to heavy economic losses the husbandry industry. Heilongjiang Province, China, is rich dairy cattle. However, its current BLV epidemiology genotypes have still not been evaluated confirmed. In this report, we investigated major regions of Province via nested PCR assay. A total 730 blood samples were collected from nine different farms six Heilongjiang. The results showed that infection rate these ranged null 31%....
Proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development and progression diabetes-related complications. (−)-Epigallocatechin gallate (EGCG), major catechin derived from green tea, is able to exert antidiabetes effects animal models. However, it not known whether or EGCG inhibits VSMC proliferation induced by high glucose. This study tested hypothesis that might have inhibitory effect on was determined [3H]-thymidine incorporation uptake...
Vascular smooth muscle cells (VSMCs) proliferation and migration, which are central in the development of vascular diseases, regulated by numerous hormones humoral factors. Activation insulin receptor stimulates VSMCs while dopamine receptors, via D1 D3 inhibit stimulatory effects norepinephrine on proliferation. We hypothesize that activation D4 may also migration VSMCs, therefore, atherosclerosis. Our current study found increased A10 cells, an effect was reduced presence a agonist,...
The sympathetic nervous system plays an important role in the regulation of blood pressure. There is increasing evidence for positive and negative interactions between dopamine adrenergic receptors; activation alpha-adrenergic receptor induces vasoconstriction, whereas vasorelaxation. We hypothesize that D1-like and/or D3 also inhibit alpha1-adrenergic receptor-mediated proliferation vascular smooth muscle cells (VSMCs). In this study, VSMC was determined by measuring [3H]thymidine...
Vascular smooth muscle cell (VSMC) proliferation is regulated by numerous hormones and humoral factors. Our previous study found that stimulation of D(1)-like dopamine receptors inhibited insulin receptor expression function in VSMCs. We hypothesize there also an interaction between D(3) receptors, i.e., the inhibits function.Receptor was determined immunoblotting, immunohistochemisty, reverse transcriptase-PCR; VSMC 3-(4,5-dimethylthiazol-2-yl)-diphenyl-tetrazolium bromide (MTT) assay...