A5100461416- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Metastasis and carcinoma case studies
- Urinary and Genital Oncology Studies
- Macrophage Migration Inhibitory Factor
- Hippo pathway signaling and YAP/TAZ
- Endometrial and Cervical Cancer Treatments
- Cardiac Fibrosis and Remodeling
- Statistical Methods in Clinical Trials
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
Fourth Hospital of Hebei Medical University
2009-2025
Hebei Medical University
2010-2025
Guiyang Medical University
2025
Army Medical University
2017-2025
Xian Central Hospital
2023
Karolinska Institutet
2023
Shanxi University of Traditional Chinese Medicine
2023
Wannan Medical College
2023
First Affiliated Hospital of Wannan Medical College
2023
Sun Yat-sen University
2009-2023
Recent researches highlighted the protective potential of pioglitazone, a PPAR-γ agonist, in progression cerebral ischemia-reperfusion injury. However, there has been no study on application pioglitazone treating ischemic stroke through mechanisms involving pyroptosis.The injury was established by middle artery occlusion (MCAO). vitro ischemia primary cultured astrocytes induced oxygen-glucose deprivation (OGD). ELISA and Western Blot analysis were employed to levels PPAR-γ,...
[177Lu]Lu-PSMA-617 (Pluvicto), a new radioligand therapy that targets prostate-specific membrane antigen (PSMA), has been approved to treat metastatic castration-resistant prostate cancer (mCRPC). However, the real-world safety profile of not systemically evaluated. Adverse event reports for were retrieved from April 2022 June 2024 The Food and Drug Administration Event Reporting System (FAERS) database. Disproportionality analysis was conducted by four algorithms: reporting odds ratio...
Pulmonary arterial hypertension (PAH) is a lethal disease characterized by pulmonary vascular obstruction due in part to excessive artery endothelial cells (PAECs) migration and proliferation. The mitochondrial fission protein dynamin-related protein-1 (DRP1) has important influence on remodeling. However, whether DRP1 participates the development progression of angiogenesis not been reported previously. To test hypothesis that promotes via promoting proliferation, stimulating migration,...
The FAS and FASL system play an important role in regulating apoptotic cell death. This study was designed to investigate the correlation of FAS-1377 G/A, -670 A/G FASL-844 T/C polymorphisms with susceptibility gastric cardiac adenocarcinoma a population high-incidence region Hebei Province.FAS-1377 were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis 262 carcinoma (GCA) patients 524 healthy controls.Family history upper gastrointestinal cancer (UGIC)...
The present study aimed to investigate the role of microRNA (miR)-141 in pathogenesis colorectal cancer (CRC). In total, 58 CRC patients were included study. mRNA and protein expression levels mitogen-activated kinase 4 (MAP4K4) detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) western blot analysis, respectively. miRNA-141 was measured RT-qPCR, while serum MAP4K4 content enzyme-linked immunosorbent assay. Natural killer (NK) cells T peripheral blood flow...
The genetic polymorphisms in E-cadherin gene (CDH1) may affect invasive/metastatic disease development by altering transcriptional activity. In this paper, we investigated the effect of 3'-UTR +54C/T polymorphism (rs1801026) CDH1 on risk and progression several common cancers. Multiple completely independent case-control analyses 1081 cancer patients with esophageal squamous cell carcinoma (ESCC), gastric cardiac adenocarcinoma (GCA), non-small-cell lung (NSCLC), cervical 1131 control...
A C/T polymorphism (rs11614913) was identified in the microRNA (miRNA) 196a2 (miR-196a2) gene and implicated susceptibility to cancer. Numerous studies have investigated its association with risk of colorectal cancer (CRC). However, results were inconsistent inconclusive. The present meta‑analysis conducted based on six published case‑control comprising 1,754 cases 2,430 controls (up November, 2012). Odds ratios (ORs) 95% confidence intervals (CIs) calculated for allelic genotypic...
Polymorphisms in DNA repair genes can alter an individual's capability and contribute to the risk of various cancers.This study was designed evaluate association single-nucleotide polymorphisms (SNPs) XPG gene with gastric cardia adenocarcinoma (GCA) a high-incidence population northern China.Two SNPs from 431 GCA patients 432 healthy controls were genotyped using polymerase chain reaction/ligase detection reaction (PCR-LDR) method.The rs751402 C/T SNP T allele T/T genotype associated...
Endometrial cancer (ECa) is a common gynecological malignancy. Circular RNAs (circRNAs) have been identified as key regulators of human tumorigenesis and development. Herein, we explored the role mechanism circular RNA intraflagellar transport 80 (circ-IFT80, also called circ_0067835) in ECa.Circ-IFT80, microRNA-545-3p (miR-545-3p), family with sequence similarity 98 member A (FAM98A) were quantified by quantitative real-time polymerase chain reaction or Western blot. The biological...
Accumulating studies have reported indispensable functions of circular RNAs (circRNA) in tumor progression through regulation gene expression. However, circRNA expression profiles and human ovarian carcinoma (OC) are yet to be fully established.In this research, deep sequencing circRNAs from OC samples paired adjacent normal tissues was performed establish circ-PHC3 levels between the groups further compared using RT-qPCR. The effects ectopic overexpression miR-497-5p SOX9 siRNA-mediated...
Circular RNA (circRNA) has been shown to play an important regulatory role in the development of various cancers, including osteosarcoma (OS). However, circRNA ABCC1 (circABCC1) OS was still poorly understood. The aim our study investigate circABCC1 progression and its potential molecular mechanisms.The expression circABCC1, microRNA-591 (miR-591) histone deacetylase 4 (HDAC4) tissues or cells detected by quantitative real-time polymerase chain reaction (qRT-PCR) western blot (WB) analyses....
Objective: To investigate the effect of hsa_circ_0000392 (circ_0000392) on radiosensitivity cervical cancer cells and explore its potential mechanism. Methods: Cervical tissues adjacent normal 42 patients with who were confirmed pathologically for first time in Huaihe Hospital Henan University from 2016 to 2019 collected. According patients' response radiotherapy, divided into radio-sensitive radio-resistant tissues. The expressions circ_0000392, miR-145-5p, CRKL radiation-sensitive,...