A5100738625- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Cancer and Skin Lesions
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Metabolism and Genetic Disorders
- Cervical Cancer and HPV Research
- Breast Lesions and Carcinomas
- Genomics, phytochemicals, and oxidative stress
- Folate and B Vitamins Research
- CAR-T cell therapy research
- Endometriosis Research and Treatment
- Chemokine receptors and signaling
- Reproductive System and Pregnancy
- Cancer, Hypoxia, and Metabolism
- Heat shock proteins research
- Ear and Head Tumors
- Clusterin in disease pathology
- PARP inhibition in cancer therapy
- Nonmelanoma Skin Cancer Studies
Hebei General Hospital
2012-2024
The University of Texas MD Anderson Cancer Center
2012
Ovarian cancer (OC) is the most common gynecological malignancy worldwide, and chemoresistance occurs in patients, resulting treatment failure. A better understanding of molecular processes underlying drug resistance crucial for development efficient therapies to improve OC patient outcomes. Circular RNAs (circRNAs) ferroptosis play roles tumorigenesis chemotherapy. However, little known about role(s) circRNAs regulating OC. To gain insights into cisplatin OC, we studied...
To identify the plasma protein biomarkers related to chemoresistance of postoperative recurrence epithelial ovarian cancers. Forty samples from patients in chemotherapy-sensitive and chemotherapy-resistant groups (20 for each group) were collected at Gynecology Department Fourth Hospital Hebei Medical University September 2013 2014. The differentially expressed proteins between two screened with two-dimensional gel electrophoresis (2-DE) further analyzed by matrix-assisted laser...
Accumulating studies have reported indispensable functions of circular RNAs (circRNA) in tumor progression through regulation gene expression. However, circRNA expression profiles and human ovarian carcinoma (OC) are yet to be fully established.In this research, deep sequencing circRNAs from OC samples paired adjacent normal tissues was performed establish circ-PHC3 levels between the groups further compared using RT-qPCR. The effects ectopic overexpression miR-497-5p SOX9 siRNA-mediated...
Abstract Since the prognosis of hypopharyngeal squamous cell carcinoma (HSCC) remains poor, identification miRNA as a potential prognostic biomarker for HSCC may help improve personalized therapy. In 2 cohorts with total 511 patients (discovery: N = 372 and validation: 139) after post‐operative radiotherapy, we used microarray qRT‐PCR to screen out significant miRNAs which might predict survival. Associations signature score these survival were performed by Kaplan‐Meier analysis multivariate...
Hypopharyngeal cancer (HC) is the most common subset of head and neck cancers. These tumors often have an aggressive clinical outcome characterized by local invasion regional nodal metastasis. Upregulated miRNAs might be useful as biomarkers for prognosis molecular targets these tumors. We determined tumor expression candidate using microarray in 8 HC patients validated 372 patients. also used paired tumorous mucosal tissue to verify miRNA expression. Log-rank test Cox model were evaluate...