A5028132727- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Head and Neck Anomalies
- Cancer-related gene regulation
- Tracheal and airway disorders
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Cancer-related Molecular Pathways
- Genetics and Neurodevelopmental Disorders
- 3D Printing in Biomedical Research
- Wnt/β-catenin signaling in development and cancer
- Water-Energy-Food Nexus Studies
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cleft Lip and Palate Research
- Neurogenesis and neuroplasticity mechanisms
- Digital Imaging for Blood Diseases
- PI3K/AKT/mTOR signaling in cancer
- Neuroscience and Neural Engineering
- Lung Cancer Diagnosis and Treatment
Guangdong Academy of Medical Sciences
2016-2025
Southern Medical University
2012-2025
Guangdong Provincial People's Hospital
2019-2025
University of Portland
2024
Hong Kong University of Science and Technology
2022-2023
University of Hong Kong
2022-2023
Oregon Health & Science University
2023
Shaoxing People's Hospital
2021
First Affiliated Hospital Zhejiang University
2021
Guangdong General Hospital
2012-2020
To investigate the most important factors affecting prognosis of patients with squamous cell carcinoma (SCC) larynx.Based on clinical and follow-up data, 205 SCC larynx receiving total laryngectomy, partial or CO2 laser surgery in GuangDong General Hospital were retrospectively analyzed. A survival analysis was performed by Kaplan-Meier method a multivariable prognostic carried out using Cox proportional hazard model.Subtypes included 69.8% glottic 30.2% supraglottic. Most N0 stage (77.6%),...
The MET receptor tyrosine kinase (RTK), implicated in risk for autism spectrum disorder (ASD) and functional structural circuit integrity humans, is a temporally spatially regulated enriched dorsal pallial-derived structures during mouse forebrain development. Here we report that loss or gain of function vitro vivo leads to changes, opposite nature, dendritic complexity, spine morphogenesis, the timing glutamatergic synapse maturation onto hippocampus CA1 neurons. Consistent with...
Neutrophil-lymphocyte ratio (NLR) has been shown to be associated with prognosis in various solid tumors. This study aimed evaluate the prognostic role of NLR patients laryngeal squamous cell carcinoma (LSCC). A total 141 LSCC were retrospectively reviewed. Patients' demographics analyzed along clinical and pathologic data. The optimal cutoff value was determined using receiver operating characteristic (ROC) curve analysis. impact other potential factors on disease-free survival (DFS)...
Abstract Laryngeal squamous cell carcinoma (LSCC) is a common head and neck cancer. Despite recently improved management of LSCC, chemotherapy resistance patients remains challenge. In this study, we identified that long noncoding RNA FOXD2-AS1 regulates LSCC therapeutic by augmenting stemness. chemotherapy-resistant showed increased expression compared with in chemotherapy-sensitive patients, which predicted poor prognosis. Gain- or loss-of-function experiments upregulated maintained cancer...
Lymphatic metastasis is a well-known factor for initiating distant of head and neck squamous cell carcinoma (HNSCC), which caused major death in most patients with cancer. Meanwhile, metabolic reprogramming to support regarded as prominent hallmark cancers. However, how disorders drive HNSCC remains unclear. We firstly established new classification based on metabolism gene expression profiles from the TCGA GEO database, identified an enriched carbohydrate subgroup was significantly...
// Si-Yi Zhang 1, * , Zhong-Ming Lu Ye-Feng Lin 1 Liang-Si Chen Xiao-Ning Luo Xin-Han Song Shao-Hua Yi-Long Wu 2 Department of Otorhinolaryngology, Guangdong General Hospital and Academy Medical Sciences, Guangzhou, Province, China Lung Cancer Institute, These authors contributed equally to this work Correspondence to: Wu, e-mail: syylwu@live.cn Zhang, szhang555@hotmail.com Keywords: biomarker, laryngeal squamous cell carcinoma, migration, miR-144-3p, prognosis Received: June 12,...
Abnormal expression of micro-ribonucleic acid (miRNA) might be clinically valuable as a biomarker or treatment target in the early diagnosis, treatment, and prognosis tumors. However, little is known concerning abnormal miRNA laryngeal carcinoma, one most commonly encountered head neck Microarray analysis was used to obtain miRNA-expression profiles ten pairs freshly frozen carcinoma tissue surrounding normal specimens. Characteristic miRNAs that were significantly related identified....
A drug and gene co-delivery system with chemotherapeutic sensibilization was prepared used for nasopharyngeal carcinoma therapy. For this purpose, the graphene oxide (GO) conjugated redox hyperbranched poly(amido amine) (HPAA) then targeting molecule, transferrin (Tf), also conjugated. The obtained Tf-HPAA-GO could co-deliver docetaxel (DOC) MMP-9 shRNA plasmid (pMMP-9) effectively showed effect to HNE-1 cells. effective delivery ability high cytotoxicity transfection efficiency. Besides...
Advanced stage laryngeal squamous cell carcinoma (LSCC) presents a poor prognosis; thus, there is great need to identify novel prognostic molecular markers. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) thought be factor in several cancers, but its role LSCC remains unknown. Cancer stem cells (CSCs) are responsible for most instances of tumor recurrence and the development drug resistance have been proven present head neck cancers. Our preliminary study indicated that PLOD2 was...
Culturing primary hippocampal neurons in vitro facilitates mechanistic interrogation of many aspects neuronal development. Dissociated embryonic can often grow successfully on glass coverslips at high density under serum-free conditions, but low cultures typically require a supply trophic factors by co-culturing them with glia feeder layer, preparation which be time-consuming and laborious. In addition, the presence may confound interpretation results preclude studies neuron-specific...
Background: Laryngeal cancer is one of the most common malignant tumors among head and neck cancers. Accumulating studies have indicated that long noncoding RNAs (lncRNAs) play an important role in laryngeal occurrence progression, however, functional roles relative regulatory mechanisms lncRNA growth arrest-specific transcript 5 (GAS5) progression remain unclear. Methods: The expression GAS5 both tissues cell lines was evaluated using quantitative reverse transcription-polymerase chain...
Abstract Background Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 laryngeal squamous cell carcinoma (LSCC) largely unknown. We aimed to explore roles LSCC and its possible molecular mechanism. Methods The expression levels were assessed lines tissue samples. further examined effect on progression. upstream regulator was identified using computer algorithm confirmed experimentally. Results highly...
Culturing primary hippocampal neurons in vitro facilitates mechanistic interrogation of many aspects neuronal development. Dissociated embryonic can often grow successfully on glass coverslips at high density under serum-free conditions, but low cultures typically require a supply trophic factors by co-culturing them with glia feeder layer, preparation which be time-consuming and laborious. In addition, the presence may confound interpretation results preclude studies neuron-specific...
MicroRNAs (miRNAs) play major roles in various biological processes and have been implicated the pathogenesis malignant progression of glioblastoma multiforme (GBM). The aim this study was to assess predictive values miRNAs for overall survival (OS) patients with GBM. MiRNA expression profiles clinical information 563 GBM were obtained from Cancer Genome Atlas. most significantly altered identified miRNA performed, through principal component analysis, least absolute shrinkage selection...
The incidence of squamous cell carcinoma the oropharynx (SCCOP) continues to rise because increasing rates human papillomavirus (HPV) infection. Inherited polymorphisms in DNA repair pathways may influence risk SCCOP development and prognosis SCCOP. We sought determine whether microRNA (miRNA)‐binding sites within 3′‐untranslated regions (3'UTRs) genes modulate recurrence. evaluated associations between nine such recurrence 1,008 patients with incident using log‐rank test multivariable Cox...
Abstract As more genes conferring risks to neurodevelopmental disorders are identified, translating these genetic risk factors into biological mechanisms that impact the trajectory of developing brain is a critical next step. Here, we report disrupted signaling mediated MET receptor tyrosine kinase ( RTK ), an established factor for autism spectrum disorders, in hippocampus glutamatergic circuit leads profound deficits neural development, synaptic transmission, and plasticity. In cultured...