A5101978690- Acupuncture Treatment Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Head and Neck Cancer Studies
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Hydrocarbon exploration and reservoir analysis
- Blood Pressure and Hypertension Studies
- Machine Learning in Bioinformatics
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Cardiovascular Health and Disease Prevention
- Gastrointestinal motility and disorders
- Circular RNAs in diseases
- Cerebrovascular and Carotid Artery Diseases
- Pain Management and Placebo Effect
- Music Therapy and Health
- Bioinformatics and Genomic Networks
- Enhanced Recovery After Surgery
- NMR spectroscopy and applications
- Bone health and osteoporosis research
- Telomeres, Telomerase, and Senescence
Beijing Tongren Hospital
2010-2024
Capital Medical University
2009-2024
Beijing Hospital of Traditional Chinese Medicine
2016-2024
Ministry of Education of the People's Republic of China
2019-2024
China National Petroleum Corporation (China)
2024
China National Offshore Oil Corporation (China)
2024
The University of Texas MD Anderson Cancer Center
2019-2024
University of Macau
2016-2019
Air Force Medical University
2015
Capital University
2011
Squamous cell carcinoma of the head and neck (SCCHN) is an aggressive disease with poor survival sixth most common cancer worldwide. Gastroesophageal reflux a event in SCCHN patients. GPR4 proton-sensing G-protein coupled receptor, which can be activated by acidosis. The objective this study was to explore role acid exposure tumor angiogenesis SCCHN. In study, we confirmed that overexpressing cells could increase expression secretion IL6, IL8 VEGFA at pH 5.9. This effect inhibited SB203580...
Abstract Background Electroacupuncture (EA) is widely used in various gastrointestinal diseases around the world, including POI. Here, we investigated different therapeutic effects of EA using lower limb and abdomen acupoints. Methods Intestinal manipulation was performed 88 mice, eight mice underwent a sham operation. Forty were randomly divided into model group four groups receiving stimulation at ST36 (2, 10, 30, 100 Hz). The most effective frequency then following experiments....
Abstract Background Differences in pretreatment body mass index (BMI) have been associated with survival squamous cell carcinoma of head and neck (SCCHN). We examined effects BMI on SCCHN patients after stratifying by tumor human papillomavirus (HPV) status subsite. Methods Totally 2204 a prospective study were included this secondary analysis. Multivariable Cox models used to evaluate associations between overall survival, disease‐specific disease‐free survival. Results was significantly...
Primary membranous nephropathy (PMN) is an autoimmune glomerular disease. IL-6 a potential therapeutic target for PMN. Previous clinical studies have demonstrated the effectiveness of Mahuang Fuzi and Shenzhuo Decoction (MFSD) in treating nephropathy. However, mechanism action MFSD remains unclear.
Objective This study was undertaken to determine the relationship between red cell distribution width (RDW) and one year outcomes in Chinese patients with stable angina pectoris. Methods A total of 1,442 pectoris on admission were divided into four groups according quartiles baseline RDW. The relationships RDW one-year cardiac mortality as well incidence acute coronary syndrome (ACS) assessed. Results Higher values associated an increased (quartile 1: 0.51%; quartile 2: 0.56%; 3: 0.86%; 4:...
To compare genome-wide DNA methylation between samples of sinonasal inverted papilloma (SNIP) and squamous cell carcinoma (SCC) in order to identify aberrantly methylated genes that might be involved malignant transformation.Tissue were collected from patients. C-phosphate-G islands gene promoters was analysed using a microarray kit. The levels mRNA or protein measured real-time polymerase chain reaction Western blot analysis.A total 27 tissue included this study; 15 SNIP 12 SCCs arising...
There is a corresponding increase in the prevalence of osteoporosis and related fractures with aging population on rise. Furthermore, osteoporotic vertebral compression (OVCF) may contribute to higher patient mortality rates. It essential conduct research risk factors for OVCF provide theoretical basis preventing such fractures. We retrospectively recruited patients who had spine CT or back pain. Demographic data were collected. Quantitative computed tomography (QCT) software analyzed data,...
Epidermal growth factor receptor (EGFR) mutations were found in 30%-40% of non-small cell lung cancer (NSCLC) patients, who often responded well to EGFR tyrosine kinase inhibitors (EGFR-TKIs) as exemplified by erlotinib and gefitinib the past decades. However, mutation-led drug resistance usually occurred upon prolonged treatment with EGFR-TKI. Herein, we study anticancer effects EGFR-TKI combination a newly developed antibody, A9(B8), target disintegrin metalloprotease (ADAM) 17 that was...
Because lymphocyte telomere length (LTL) plays critical roles in the maintenance of genomic stability and integrity, LTL thus may influence etiology prognosis squamous cell carcinoma oropharynx (SCCOP). However, given association between risk human papillomavirus (HPV)-associated SCCOP tumor HPV status SCCOP, we hypothesized that is associated with prognosis, particularly HPV-positive patients after definitive radiotherapy. type 16 (HPV16) were determined 564 incident before radiotherapy or...
Endothelial dysfunction is the initial stage in atherosclerotic formation and progression associated with high serum uric acid (SUA) level. We hypothesized that reactive hyperemia index (RHI), which reflects endothelial function, SUA levels elderly individuals untreated mild hypertension.We recruited 123 patients ≥ 60 years hypertension. The association between level RHI was analyzed using univariate correlation analysis multiple regression analysis. receiver operating characteristic (ROC)...
Postprandial distress syndrome (PDS) has a considerable impact on quality of life. Our previous pilot trial suggested that acupuncture might be potential treatment option for PDS. We will conduct this large to determine the efficacy versus sham PDS.A total 280 eligible patients who meet Rome IV criteria PDS randomly allocated either group or group. Each patient receive 12 sessions over four weeks. The primary outcomes response rate overall effect (OTE) and elimination all three cardinal...
Background: Evidence for treating postprandial distress syndrome with acupuncture is limited. Aim: We aimed to evaluate the feasibility of verum versus sham in patients syndrome. Methods: A total 42 eligible were randomly allocated either or groups a 1:1 ratio. Each patient received 12 sessions over 4 weeks. The primary outcome was response rate based on overall treatment effect (OTE) weeks after randomization. Secondary outcomes included dyspepsia symptom severity and adverse events....
Objective To investigate the effect of electroacupuncture (EA) at different acupoint combination on intestinal motility and expression inflammatory factors IL-6 TNF-α in muscle layer mice with postoperative ileus (POI), so as to provide reference clinical EA intervention for POI. Methods A total 78 SPF-grade male C57BL/6 aged 8-12 weeks were randomly divided into a sham operation group, model ST 36+ non-acupoint 25 CV 4 group 12 13 each group. The POI was established by manipulation....
Abstract Low resistivity pay (LRP) has become a valuable resource globally. Estimated reserve of more than 100 million cubic meters explored hydrocarbon is stored in LRP zones the N1g formation Bohai Bay. It important to identify and evaluate them order improve reservoir productivity. In layer, production well testing data have shown zone normally lower adjacent water zones. As result, identification these can be quite challenging, particularly wells where spontaneous potential...
Abstract Currently, the proven reserve of low resistivity pays (LRP) exceed 100 million cubic meters in Guantao Formation, Bohai Basin. These LRP reservoirs are a crucial component increasing both reserves and production this oilfield. In general, can be defined as with ratio less than 2 between oil-bearing adjacent water-bearing intervals. Production testing Formation have confirmed that intervals is even lower neighboring As result, identification zones quite challenging, particularly...