A5101750288- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Acute Myocardial Infarction Research
- Extracellular vesicles in disease
- Chronic Kidney Disease and Diabetes
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- Traditional Chinese Medicine Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Cardiovascular Syncope and Autonomic Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Frailty in Older Adults
- MicroRNA in disease regulation
- Cardiac Arrhythmias and Treatments
- Cancer Treatment and Pharmacology
- Folate and B Vitamins Research
- Retinoids in leukemia and cellular processes
- Cardiovascular Disease and Adiposity
- Circular RNAs in diseases
- Diabetes Treatment and Management
- Climate change impacts on agriculture
Capital Medical University
2014-2024
Shanghai Sixth People's Hospital
2011-2023
Shanghai Jiao Tong University
2011-2023
Nanjing University of Information Science and Technology
2023
Xuan Wu Hospital of the Capital Medical University
2022
National Clinical Research Center for Digestive Diseases
2020
Beijing Friendship Hospital
2014
We investigated the relationship between platelet to lymphocyte ratio (PLR) and contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). enrolled 5719 3 tertiary hospitals from January 2005 December 2010. The PLR was calculated as of counts on admission. Serum creatinine level measured before within 72 hours after contrast medium administration. To evaluate relation CIN, were divided...
Cisplatin (DDP) is widely used in cancer treatment, but DDP can cause skeletal muscle atrophy and cachexia. This study explored the effect mechanism of daidzein (DAI) reducing DDP‐induced cachexia vivo vitro. DAI alleviated weight, food intake, muscle, adipose tissue, kidney weight forelimb grip LLC tumour‐bearing mice after did not affect antitumour DDP. reduce decrease cross‐sectional area fibre‐induced by prevent change fibre type proportion. In it inhibit Glut4/AMPK/FoxO pathway,...
Introduction Inflammation is a key driver of adverse outcomes in acute myocardial infarction (AMI), yet current western anti-inflammatory therapies are limited by their single-target nature and side effects. Traditional Chinese medicine (TCM), such as Tanhuo Decoction (THD), offers multi-target, low-toxicity alternative. Methods In randomized controlled trial, AMI patients with high inflammatory responses received either standard Western (WM) alone or combined THD for 3 days. Clinical...
Recent studies have reported increased red blood cell distribution width (RDW) has been associated with adverse outcomes in heart failure and stable coronary disease. We investigated the association between RDW risk of all-cause mortality patients ST-elevation myocardial infarction (STEMI) who were free at baseline.We enrolled 691 STEMI baseline confirmed by angiography Beijing Friendship Hospital from January 2007 to December 2008. According median (13.0%) on admission, divided into two...
The clinical use of doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity. present study investigated the effects scutellarin against DOX-induced cardiotoxicity in rats using pharmacodynamic and pharmacokinetic approaches. DOX (20 mg/kg) was injected intraperitoneally (i.p.) as a single dose, (5 mg/kg/day) intravenously (i.v.) for 3 days. Rats treated with showed acute indicated elevated serum lactate dehydrogenase (LDH) activity (4057.8 ± 107.2 vs. 2032.7 70.95), tissue...
Accumulated oncometabolites in the tumor microenvironment (TME) suppresses metabolism, expansion, and function of T cells. Immunosuppressive TME also impeded Chimeric Antigen Receptor (CAR)-T cells mediated cytotoxicity since CAR-T had to adapt vivo metabolic characteristics with high levels oncometabolites. We screened for inhibition glucose uptake CD8 + found Kynurenine (Kyn) showed strongest inhibiting effect on uptake. In vitro experiments that 120 μM Kyn treatment resulted expansion...
The anthracycline antibiotic doxorubicin (DOX) is an effective anticancer agent, but its clinical use limited by dose-dependent cardiotoxicity. Scutellarin (SCU), a natural polyphenolic flavonoid, used as cardioprotective agent for infarction and ischemia-reperfusion injury. This study investigated the beneficial effect of SCU on DOX-induced chronic Rats were injected intraperitoneally (i. p.) with DOX (2.5 mg/kg) twice week four weeks then allowed to rest two establish cardiotoxicity animal...
We investigated the association between platelet-to-lymphocyte ratio (PLR) and clinical outcomes (including all-cause mortality, recurrent myocardial infarction, heart failure, serious cardiac arrhythmias ischemic stroke) in patients with ST-segment elevation infarction (STEMI). Based on PLR quartiles, 5886 STEMI were categorized into 4 groups: <98.8 (n = 1470), 98.8 to 125.9 1474), 126.0 163.3 1478), >163.3 1464), respectively. used Cox proportional hazards models examine relation outcomes....
Exosome secretion is an important paracrine way of endothelial progenitor cells (EPCs) to modulate resident cells. The osteocalcin (OCN)-expressing EPCs have been found be increased in cardiovascular disease patients and are considered involved the process coronary atherosclerosis. Since OCN has proven prevent dysfunction, this study aimed evaluate effect exosomes derived from OCN-overexpressed on Exosomes (Exos) (OCN-Exos) were isolated incubated with rat aorta (RAOECs) or without...
Cisplatin (DDP), a widely used chemotherapeutic drug in cancer treatment, causes oxidative stress, resulting cachexia and skeletal muscle atrophy. This study investigated the effects activity of silibinin (SLI) reducing DDP-induced stress atrophy vivo vitro. SLI alleviated weight loss, food intake, wasting, adipose tissue depletion, organ reduction induced by DDP improved grip force caused DDP. can attenuated increase reactive oxygen species (ROS) levels, decrease Nrf2 expression, fiber...
Abstract The main features of cancer cachexia include skeletal muscle atrophy, which can significantly reduce the quality life patients. Clinical treatment is mainly based on nutritional therapy and physical exercise; medication only improves appetite but does not reverse symptoms wasting. In this work, we systematically studied underlying molecular mechanisms by cucurbitacin IIb (CuIIb) ameliorates wasting in both vitro vivo. CuIIb ameliorated chief vivo, alleviating weight loss, food...
Conflicting evidence still exists regarding Vitamin B12's involvement in coronary heart disease (CHD). There is no precedent for previous studies to include both B12, B6, as well E the consideration of CHD associating factors. Our data derived from National Health and Nutrition Examination Survey (NHANES), which covers period 2003-2020. 33,640 samples were included this cross-sectional study. We used an unadjusted covariates three adjusted covariates. The intake percentage Vitamins E, B12...
Skeletal muscle atrophy is an important feature of cancer cachexia, which can be induced by chemotherapy, and affects the survival quality life patients seriously. No specific drugs for cachexia have been applied in clinical practice. This study explored therapeutic effect linalool (LIN) on cisplatin (DDP) skeletal atrophy. In vivo , LIN improve weight loss, anorexia, strength decline other symptoms caused treatment a Lewis lung tumor bearing mouse model, cause no adverse effects anti-tumour...
<sec><strong>Objective</strong> To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with long-term clinical outcome in patients coronary heart disease (CHD) undergoing percutaneous intervention (PCI). </sec><sec><strong>Methods</strong> In total, 675 were enrolled. Based platelet inhibition rate, categorized into two groups: low responsiveness (CLR) normal (NCR). The CLR group was divided ticagrelor based antiplatelet drugs used follow-up...
In this present study, a stereospecific HPLC method that could separate two enantiomers (R/S epimer) of naringenin in bottom base has been developed and validated, then further applied it to determine stereoselective pharmacokinetics rats. method, normal phase column (Chiralpak AD-H) was used mobile consisting n-hexane, isopropanol, trifluoroacetic acid with gradient elution program. The ultraviolet detection wavelength at 288 nm injection volume 20 μL. temperature 30 °C, flow rate 0.8...
Osteosarcoma (OS) is the most common primary bone sarcoma, chemoresistance becomes an obstacle to its treatment. Metabolic reprogramming a hallmark of malignancy, targeting metabolic pathways might provide reasonable therapeutic strategy for OS. Here we demonstrated that Ailanthone (AIL), major component Chinese medicine Ailanthus altissima, significantly suppressed OS cell growth in vitro and vivo. Furthermore, AIL dose-dependently inhibited migration invasion, induced cycle arrest...
We investigated the association between mean platelet volume (MPV) and risk of all-cause mortality in Chinese patients with ST-Elevation Myocardial Infarction (STEMI). enrolled 1836 STEMI Xuanwu Hospital from January 2008 to December 2013. Based on MPV, were categorized into following groups: < 9.5 fL (n = 85), 9.5-11.0 776), 11.1-12.5 811) >12.5 164), respectively. Mean duration follow-up was 56.9 months, 197 (10.7%) died during follow-up. All-cause rates compared groups. The lowest...
Reserpine is currently used by millions of Chinese hypertensive patients, in spite the continued concern its depressogenic effect, even when low dose. This study aimed to investigate association between low-dose reserpine use and depression older patient.In this cross-sectional, case-control study, we recruited patient aged 60 years or over who had regularly taken one two tables "compound triamterene tablets (CRTTs)" for more than year (reserpine user) from 26 community health centers...
Abstract Cancer cachexia is characterized by weight loss and skeletal muscle wasting. Based on the up-regulation of catabolism down-regulation anabolism, here we showed genetic mutation-mediated metabolic reprogramming in progression cancer screening for metabolites investigating their direct effect atrophy. Treatment with 93 μM D-2-hydroxyglutarate (D2HG) resulted reduced myotube width increased expression E3 ubiquitin ligases. Isocitrate Dehydrogenase 1 ( IDH1 ) mutant patients had higher...
Background Although the relationship of either hemoglobin or red blood cell distribution width (RDW) with contrast-induced nephropathy (CIN) has been reported individually. To date, no studies have evaluated predictive value hemoglobin-to-red ratio (HRR) for CIN. Methods A total 1658 elderly patients ST-segment elevation myocardial infarction (STEMI) undergoing emergency percutaneous coronary intervention (PCI) were retrospectively screened. Preoperative complete count was collected and HRR...
Abstract Background Endothelial dysfunction may play a key role in non-obstructive coronary artery atherosclerosis. Our study aimed to evaluate the vascular endothelial function and its influencing factors patients with Methods A total of 131 consecutive atherosclerosis were enrolled. Flow-mediated dilatation (FMD) was measured at baseline 1-year follow-up. progenitor cells (EPCs) counted by staining fasting venous blood antibodies against CD34 growth factor receptor 2. Results Systolic...
Endothelial dysfunction is the initial stage in atherosclerotic formation and progression associated with high serum uric acid (SUA) level. We hypothesized that reactive hyperemia index (RHI), which reflects endothelial function, SUA levels elderly individuals untreated mild hypertension.We recruited 123 patients ≥ 60 years hypertension. The association between level RHI was analyzed using univariate correlation analysis multiple regression analysis. receiver operating characteristic (ROC)...