A5074131037- Acute Myocardial Infarction Research
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Imaging and Diagnostics
- RNA modifications and cancer
- Cerebrovascular and Carotid Artery Diseases
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Inflammatory Biomarkers in Disease Prognosis
- Vascular Procedures and Complications
- Cardiovascular Disease and Adiposity
- Electric and Hybrid Vehicle Technologies
- Pesticide Residue Analysis and Safety
- Advanced Battery Technologies Research
- Electric Vehicles and Infrastructure
- Peripheral Artery Disease Management
- Calcium signaling and nucleotide metabolism
- Cardiac Health and Mental Health
- Sepsis Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Vascular anomalies and interventions
LMU Klinikum
2024
Ludwig-Maximilians-Universität München
2024
Heidelberg University
2022-2023
University Hospital Heidelberg
2022-2023
Guangxi University
2023
Tianjin Medical University
2023
Capital Medical University
2014-2022
Beijing Friendship Hospital
2014-2022
State Key Laboratory of Vehicle NVH and Safety Technology
2020
Recent studies have reported increased red blood cell distribution width (RDW) has been associated with adverse outcomes in heart failure and stable coronary disease. We investigated the association between RDW risk of all-cause mortality patients ST-elevation myocardial infarction (STEMI) who were free at baseline.We enrolled 691 STEMI baseline confirmed by angiography Beijing Friendship Hospital from January 2007 to December 2008. According median (13.0%) on admission, divided into two...
The prognosis of unstable angina pectoris (UAP) differs from non-ST-segment elevation myocardial infarction, and percutaneous coronary intervention (PCI) is considered to improve outcomes UAP. This study aimed assess the prognostic value uric acid albumin ratio (UAR) for long-term mortality in UAP patients after PCI. Our retrospectively enrolled 2298 hospitalized because a tertiary hospital. Divided by medium UAR, were classified into two groups. Baseline demographics, clinical features...
Objectives Neutrophil-to-lymphocyte ratio (NLR), one of the composite biomarker systemic inflammatory status, was proved promising in predicting clinical outcomes acute coronary syndrome (ACS). However, there were no evidences that NLR directly relative to unstable angina pectoris (UAP). Therefore, this study aimed detect whether could predict artery lesion severity (indicated as SYNTAX score) and (especially long-term cardiovascular mortality) patients with.Methods In single-centre...
Coronary artery ectasia (CAE) is a rare disease and substantial portion of patients with CAE are first diagnosed acute myocardial infarction (AMI). The question was raised if kind thrombotic disease. We assessed consecutive series 119 including 32 AMI (CAE + group) 87 without group). During the same period, 90 coronary heart disease, normal arteries (control), 120 (AMI were randomly selected evaluated. Both current previous prevalence rates in population higher than rate for other undergoing...
Desorption/ionization (DI)-mass spectrometric (MS) methods offer considerable advantages of rapidity and low-sample input for the analysis solid biological matrices such as tissue sections. The concept desorption electrospray ionization (DESI) offers possibility to ionize compounds from surfaces at atmospheric pressure, without addition organic initiate desorption. However, severe drawbacks former DESI hardware stability made development assays drug quantification difficult. In present...
Background Previous studies suggested that adiponectin (APN) could ameliorate ischemia/reperfusion injury and endothelial dysfunction in patients with acute myocardial infarction. However, the relationship between serum APN level coronary flow after primary percutaneous intervention (PPCI) ST‐segment elevation infarction (STEMI) is unclear. Methods A total of 144 STEMI treated by PPCI were enrolled divided into two groups based on mean admission. The data angiograms laboratory examinations...
Most of coronary artery ectasia (CAE) patients have comorbid atherosclerosis. It was lack prognostic data for CAE with heart disease (CHD) and whom acute myocardial infarction (AMI).To determine the overall prognosis patients.This study a retrospective cohort study. Fifty-one AMI (CAE + AMI) 108 CHD CHD) were enrolled matched to non-CAE subjects at ratio 1:3 using propensity score method, respectively. Controls group 153 patients, controls 324 329 participants relatively normal arteries...
There is no consensus on the antithrombotic treatment strategy for patients with coronary artery ectasia (CAE).This case reports dynamic observation of a patient 48 mo after diagnosis CAE acute myocardial infarction (AMI). The first agents used were aspirin (100 mg/d) and clopidogrel (75 mg/d). During sixth month observation, second AMI occurred involving same culprit vessel; therefore, changed to ticagrelor (90 mg twice per day). Twelve months AMI, an attempt reduce dosage failed; therefore...
Objective: It is essential to understand whether coronary artery ectasia (CAE) progresses over time because the patients might be under risk of rupture, and stent implant should avoided if ectatic changes progress. Methods: A consecutive series 99 CAE who had undergone angiography at least twice were enrolled followed up for 1–16 years until they received a second angiogram. Subjects divided into two groups (1–5 vs. 5–16 follow-up), then basic clinical characteristics images compared time....
Abstract The spreading of Tau pathology is closely associated with the progression neurodegeneration and cognitive decline in Alzheimer’s disease other tauopathies. A key event this process rupture endolysosomal vesicles following intercellular transfer aggregates, releasing transferred species into cytosol where they can promote aggregation endogenous Tau. However, understanding cellular pathways involved remains limited. In study, we investigated that prevent vesicle rupture. We...
BACKGROUND:Alpha1-microglobulin (A1MG) is a small molecular protein related to oxidation and inflammation. It exists in diverse body fluids, including urine. Results from urine tests are sometimes neglected when predicting in-hospital prognosis. remains unclear whether urinary A1MG (UA1MG) can predict short-term prognosis of ST-elevated myocardial infarction (STEMI). MATERIAL AND METHODS:A total 1854 hospitalized patients with acute STEMI were retrospectively enrolled our study. Medical...
Damage to elastin fibres in coronary media might lead artery ectasia (CAE). This study evaluated whether CAE can be distinguished by detecting circulating soluble (s-elastin), which is a degradation product of fibres, and elastase, the main enzyme fibres.Fifty-eight patients with CAE, 58 heart disease (CHD) 61 relatively normal arteries, were included. Circulating s-elastin elastase measured, receiver operating characteristic curves used demonstrate their respective optimal cut-off values...
目的 评价经桡动脉使用短头AL(SAL)指引导管对急性下壁心肌梗死患者直接进行冠状动脉造影及经皮冠状动脉介入治疗(PCI)的疗效与安全性。 方法 入选我院心血管中心收治的急性下壁心肌梗死患者51例，按随机数字表法分成SAL组25例及对照组26例，均采用桡动脉途径，SAL组直接使用SAL指引导管完成冠状动脉造影及PCI，对照组使用多功能造影管完成冠状动脉造影，再根据病变情况选择合适指引导管完成PCI。比较两组患者完成冠状动脉造影所用时间(Time1)、完成球囊扩张所用时间(Time2)以及完成PCI术所用时间(Time3)，并观察SAL指引导管的安全性及9个月随访期内的主要不良心血管事件(MACE)。 结果 51例患者均成功完成冠状动脉造影及PCI。两组患者Time1差异无统计学意义，SAL组Time2[(10.64±2.16)min比(13.85±1.95)min]及Time3[(23.88±4.83)min比(28.50±6.77)min]均显著低于对照组(均为P<0.05)。SAL组患者均未发生冠状动脉开口或近端夹层，住院期间未发生死亡及支架内血栓；...
The development of desorption/ionization (DI) mass spectrometric (MS) assays for drug quantification in tissue sections and their validation according to regulatory guidelines would enable universalization applications (clinical) pharmacology. Recently, new enhancements desorption electrospray ionization (DESI) have highlighted the reliability this ion source targeted methods that meet requirements method validation. However, it is necessary consider subtle parameters leading success such...
Quantitative monitoring of biologically active methylations guanines in samples exposed to temozolomide (TMZ) would be useful glioblastoma research for preclinical TMZ experiments, clinical pharmacology questions regarding appropriate exposure, and ultimately precision oncology. The known alkylation DNA induced by takes place on O6 position guanines. However, when developing mass spectrometric (MS) assays, the possible signal overlap O6-methyl-2'-deoxyguanosine (O6-m2dGO) with other...
With the rapid development of industry, increasing discharge sewage causes detection water quality to be importance. Potassium dichromate titration is one most important testing methods in detection; ability accurately identify end-point potassium currently a research challenge. To quickly and accurately, this study proposes ResNet14Attention network, which utilizes residual modules that focus on original image information an attention mechanism focuses highly classification targets. The...
Lung cancer is one of the most common malignant solid tumors and leading cause cancer‑associated mortality worldwide. Endocytosis an essential physiological activity for cells to maintain membrane homeostasis, has been reported serve important role in tumorigenesis progression. In present study, aim was construct a prognostic prediction model endocytosis‑associated genes patients with lung adenocarcinoma (LUAD). The gene signature established using Lasso Cox regression analysis training set...