Abstract Background Triglyceride glucose (TyG) index is considered a reliable alternative marker of insulin resistance and an independent predictor cardiovascular (CV) outcomes. However, the prognostic value TyG in patients with type 2 diabetes mellitus (T DM) acute myocardial infarction (AMI) remains unclear. Methods A total 1932 consecutive T DM AMI were enrolled this study. Patients divided into tertiles according to their levels. The incidence major adverse cardiac cerebral events...

Triglyceride glucose (TyG) index is considered a new surrogate marker of insulin resistance that associated with the development vascular disease. The aim this study was to evaluate prognostic value TyG in patients acute myocardial infarction (AMI).A total 3181 AMI were included analysis. Patients stratified into 2 groups according their levels: <8.88 group and ≥8.88 group. incidence major adverse cardiovascular events (MACEs) during median 33.3-month follow-up recorded. Multivariable Cox...

Aim: To evaluate the prognostic value of triglyceride-glucose (TyG) index in nondiabetic patients with acute coronary syndrome (ACS) low-density lipoprotein cholesterol (LDL-C) below 1.8 mmol/L.

Advanced glycation end products (AGEs) can damage voltage-gated K+ (Kv) channels and attenuate coronary artery vasodilation, but the underlying mechanisms remain unclear. The aim of this study was to investigate role potential mechanism PPARγ in AGEs-induced Kv 1 impairment. We used both primary rat smooth muscle cells (CSMCs) vitro Zucker Diabetic Fatty (ZDF) model vivo. Overexpression Pparg gene by lentivirus vector (LV-Pparg) transfect CSMCs for upregulation PPARγ. 1.2 1.5 currents were...

Pregnancy-associated plasma protein A (PAPP-A) was previously reported to be an inflammatory biomarker and a prognostic marker of acute coronary syndrome (ACS) involved in the process atherosclerosis plaque rupture. However, role PAPP-A inflammation is poorly understood. In this study, we aimed investigate macrophage activation cytokine production. RAW264.7 macrophages were treated with or without PAPP-A. Reverse-transcriptase quantitative real-time PCR (RT-qPCR) Western blot performed...

Current guidelines recommend angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) as a first-line therapy in diabetic hypertensive patients and for secondary prevention with obstructive coronary artery disease (OCAD). However, the effects of using ACEI/ARB before initial diagnosis OCAD on major adverse cardiac cerebral event (MACCE) remain unclear. This study investigated whether could be associated improved clinical outcomes patients.

Renal interstitial fibrosis and glomerulosclerosis are the characteristic presentation of diabetic nephropathy progression. Twist-1 overexpression contributes to renal fibrosis. Previous studies have demonstrated that pioglitazone (PIO), a PPAR-γ agonists, can ameliorate protect function. However, whether PIO attenuates delays progression by regulating expression remains unclear.Male Zucker fatty (ZDF) rats were randomly divided into 3 groups: (1) ZDF group, (2) + group treated with for 10...

Acute myocardial infarction (AMI) is the most prevalent cause of mortality and morbidity in patients with type 2 diabetes mellitus (T2DM). However, strict blood glucose control does not always prevent development progression AMI. Therefore, present study aimed to explore potential new biomarkers associated occurrence AMI T2DM patients.A total 82 participants were recruited, including group (n = 28), without (T2DM, n 30) initial (T2DM + AMI, 24). The untargeted metabolomics using liquid...

Excessive formation of advanced glycation end products (AGEs) impairs voltage-gated potassium (Kv) channels in rat coronary artery smooth muscle cells (CSMCs), resulting weakened Kv-mediated vasodilation. We hypothesized that induction the nuclear factor-κB (NF-κB) signaling pathway by AGEs plays a significant role regulation Kv channel-mediated vasodilation Zucker diabetic fatty (ZDF) rats. Assays mRNA transcripts, protein expression, and intracellular localization as well patch-clamp...

The role of advanced glycation end products (AGEs) and its C-terminal truncated receptor (soluble for products, sRAGE) in ST-segment elevation myocardial infarction (STEMI) patients with or without diabetes is unknown. We compared their levels STEMI, as well diabetes. A prospective observational study was performed between December 2014 2015. Study group included STEMI coronary artery disease; control disease. Levels AGEs sRAGE were tested on Days 0, 2, 5 after STEMI. creatine kinase-MB...

Abstract Background: Triglyceride glucose (TyG) index is considered a reliable alternative marker of insulin resistance and an independent predictor cardiovascular outcomes. However, the prognostic value TyG in patients with type 2 diabetes mellitus (T DM) acute myocardial infarction (AMI) remains unclear. Methods: A total 1932 consecutive T DM AMI were enrolled this study. Patients divided into tertiles according to their levels. The incidences major adverse cardiac cerebral events...

Abstract Background Triglyceride glucose (TyG) index is considered a new marker for metabolic disorders. Although recent studies have found an association between TyG level and vascular disease development, the prognostic value of in patients with acute myocardial infarction (AMI) remains unclear. Methods A total 3181 AMI, who underwent coronary angiography, were identified from Cardiovascular Center Beijing Friendship Hospital Database Bank included analysis. Patients stratified into 2...

Better survival for overweight and obese patients after ST-segment elevation myocardial infarction (STEMI) has been demonstrated. The association between body mass index (BMI), microvascular obstruction (MVO), area at risk (AAR) STEMI was evaluated.A prospective observational study performed to enrolled undergoing primary percutaneous coronary intervention (pPCI) cardiac magnetic resonance within 5-7 days. Patients were classified as normal weight (18.5 ≤BMI <24.0 kg/m2), (24.0 <28.0 or (BMI...

Background: Intramyocardial hemorrhage (IMH) is a result of ischemia-reperfusion injury in ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PPCI). Despite patients with IMH show poorer prognoses, studies investigating predictors occurrence are scarce. This study firstly investigated the effectiveness regulatory T cell (Treg), peak value Creatine Kinase MB (pCKMB), high-sensitivity C-reactive protein (hsCRP), and left ventricular...

Abstract Background: Current guidelines recommend angiotensin-converting-enzyme inhibitors (ACEI) /angiotensin receptor blockers (ARB) as a first-line therapy in diabetic hypertensive patients and for secondary prevention with obstructive coronary artery disease (OCAD). However, the effects of using ACEI/ARB before initial diagnosis OCAD on major adverse cardiac cerebral event (MACCE) remain unclear. This study investigated whether could be associated improved clinical outcomes patients....

Abstract Background High blood glucose impairs voltage-gated K + (Kv) channel-mediated vasodilation in rat coronary artery smooth muscle cells (CSMCs) via oxidative stress. Advanced glycation end product (AGE) and receptor for AGE (RAGE) axis has been found to impair dilation by reducing Kv channel activity diabetic small arteries (RSCAs). However, its underlying mechanism remain unclear. Here, we used isolated primary CSMCs investigate the effect of incubation on possible involvement...

Abstract Background Triglyceride glucose (TyG) index is considered a new marker for metabolic disorders. Although recent studies have found an association between TyG level and vascular disease development, the prognostic value of in patients with acute myocardial infarction (AMI) remains unclear. Methods A total 3181 AMI, who underwent coronary angiography, were identified from Cardiovascular Center Beijing Friendship Hospital Database Bank included analysis. Patients stratified into 2...