A5074322926- Osteoarthritis Treatment and Mechanisms
- Hepatitis B Virus Studies
- Helicobacter pylori-related gastroenterology studies
- Hepatitis C virus research
- Medical Research and Treatments
- Effects of Radiation Exposure
- Restless Legs Syndrome Research
- Virus-based gene therapy research
- Periodontal Regeneration and Treatments
- Dementia and Cognitive Impairment Research
- Cardiovascular Function and Risk Factors
- Genetic and Kidney Cyst Diseases
- Parkinson's Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Cerebrospinal fluid and hydrocephalus
- Birth, Development, and Health
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- Galectins and Cancer Biology
- Fetal and Pediatric Neurological Disorders
- Scientific and Engineering Research Topics
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects and Toxicity Studies
- Studies on Chitinases and Chitosanases
- Adrenal Hormones and Disorders
Guangxi University
2025
Guangxi University of Chinese Medicine
2025
Sichuan University
2014-2024
West China Hospital of Sichuan University
2023-2024
Zhejiang University
2023
Integrated Chinese Medicine (China)
2023
Guangzhou Medical University
2022
Zhongnan Hospital of Wuhan University
2018-2022
Wuhan University
2018-2022
First Affiliated Hospital of Guangzhou Medical University
2022
Andrographolide is an active component from the extract of Andrographis paniculata [(Burm.f) Nees], a medicinal plant Acanthaceae family. Pharmacological studies have revealed that andrographolide possesses anti-bacterial, anti-inflammatory, anti-viral, immune regulatory and hepatoprotective properties, efficacious in treatment cardiovascular diseases, while exhibiting low toxicity cost. The present study aimed to determine inhibitory effects on growth multiple myeloma (MM) cells its...
Abstract: Periodontal regeneration is an important part of regenerative medicine, with great clinical significance; however, the effects nanotopography on functions periodontal ligament (PDL) stem cells (PDLSCs) and PDLSC sheet based have never been explored. Titania nanotubes (NTs) layered titanium (Ti) provide a good platform to study this. In current study, influence NTs different tube size PDLSCs was observed. Afterward, ectopic implantation model using Ti/cell sheets/hydroxyapatite (HA)...
Periodontitis is a common inflammatory disorder affecting the tissues surrounding teeth, which can lead to destruction of periodontal tissue and tooth loss. Resveratrol, natural phytoalexin, exerts multiple biological effects. For example, its anti‑inflammatory activity has been widely studied for treatment bowel disease number years. However, effect on bone repair new formation in an microenvironment not well understood. Accordingly, resveratrol inflammation‑affected human ligament stem...
Fetal-originated osteoarthritis is relative to poor cartilage quality and may exhibit transgenerational genetic effects. Previous findings revealed prenatal dexamethasone exposure (PDE) induced in offspring.This study focused on further exploring molecular mechanism, heritability, early intervention of fetal-originated osteoarthritis.Pregnant rats (F0) were segregated into control PDE groups depending upon whether was administered gestational days (GDs) 9-20. Some female offspring bred with...
KIAA0101 always overexpresses in tumor tissues, which is also a marker of recurrence. This study aims to explore whether overexpression mRNA peripheral blood mononuclear cells (PBMCs) could act as noninvasive and predictive biomarker hepatic cancer. Real-time polymerase chain reaction (RT-PCR) was employed detect expression PBMCs isolated from 93 cancer patients 55 healthy individuals. The diagnostic sensitivity specificity mRNA, CEA, CD44V were analyzed compared. A multivariate logistic...
Objective: To explore the improvement rate of liver fibrosis in patients with chronic hepatitis B virus infection who received entecavir alone or combination anluohuaxianwan for 78 weeks. Methods: Patients HBV were randomly treated anluohuaxian Ishak score was used blind interpretation biopsy specimens. The condition before and after treatment compared. Student's t test non-parametric (Mann-Whitney U-Test Kruskal-Wallis test) to analyze measurement data. categorical variables analyzed by...
The success of direct-acting antivirals (DAAs) against hepatitis C virus is a major breakthrough in hepatology. Previous studies have shown that chitinase 3-like protein 1 (CHI3L1) was marker for staging liver fibrosis caused by HCV. In this investigation, we used CHI3L1 as surrogate to compare dynamic hepatic variations following the elimination HCV among cases receiving sofosbuvir (SOF)-based regimens and pegylated interferon/ribavirin (PR) treatments. study enrolled 105 patients,...
Although convergent evidence has shown that patients with mild stroke (MS) are commonly accompanied by post-stroke cognitive and/or memory impairment, only disproportionate attention was paid compared to severe stroke. To promote management for early intervention in MS-related a feasible and convenient method MS detection is, therefore, favorable. A data-driven classification framework combined quantitative graph theoretical analysis introduced this work, aiming provide comprehensive...
To evaluate the clinical efficacy and safety of Heyan Kuntai capsule (HYKT) in treating women with infertility caused by diminished ovarian reserve (DOR). One hundred eight eligible patients from three Chinese hospitals were randomly divided into an HYKT treatment group (n = 55) ora dehydroepiandrosterone (DHEA) 53). Patients treated orally four 0.5 g times a day; DHEA one 25.0 mg day. All for 3 months followed up over 3-month period. Of 108 patients, 12 dropped out: six group, group. Eleven...
A Chinese Herbal Formula (CHF) has acquired a certain therapeutic effect on chronic HBV infection. To assess the efficacy and safety of CHF replication in carriers, we performed randomized, double-blind, placebo-controlled trial involving patients from 16 centers. total 300 confirmed carriers were randomized at baseline ratio 2 : 1 to receive either or placebo for 52 weeks. The results showed that greater proportion than treated achieved virological response week 52; mean decline serum HBsAg...
The current study aimed to explored the regulatory effect of Tropomyosin-related kinases B (TrkB) in development and function chondrocyte. Correlation between clinicopathological characteristics osteoarthritis (OA) were analyzed. expressions TrkA, brain-derived neurotrophic factor (BDNF), TrkB, Src homolog collagen (ShcB), ShcC OA cartilage tissue IL-1β-stimulated chondrocytes from normal determined by Western blot/qRT-PCR. After manipulating shTrkB, ShcB, miR-146a-3p nuclear paraspeckle...
Abstract Background Triglyceride glucose (TyG) index is considered a new marker for metabolic disorders. Although recent studies have found an association between TyG level and vascular disease development, the prognostic value of in patients with acute myocardial infarction (AMI) remains unclear. Methods A total 3181 AMI, who underwent coronary angiography, were identified from Cardiovascular Center Beijing Friendship Hospital Database Bank included analysis. Patients stratified into 2...
Our previous study reported that prenatal caffeine exposure (PCE) could induce chondrodysplasia and increase the susceptibility to osteoarthritis in offspring rats. However, potential mechanisms initiating factors remain unknown. This aims investigate whether 11β-HSD2, a glucocorticoid-metabolizing enzyme, is involved of induced by PCE further explore its factors. Firstly, we found reduced cartilage matrix synthesis (aggrecan/Col2a1 expression) male adult rats exhibited an phenotype...
Idiopathic normal pressure hydrocephalus (iNPH) is highly prevalent among elderly individuals, and there a strong correlation between telomere length biological aging. However, limited evidence to elucidate the relationship iNPH. This study aimed investigate associations iNPH using Mendelian randomization (MR) method.
Abstract Background Idiopathic normal pressure hydrocephalus (iNPH) is highly prevalent among elderly individuals, and there a strong correlation between telomere length biological aging. However, limited evidence to elucidate the relationship iNPH. This study aimed investigate associations iNPH using Mendelian randomization (MR) method. Method The genetic variants of were obtained from 472,174 UK Biobank individuals. Summary level data acquired 218,365 individuals FinnGen consortium. Five...
Previous studies have reported that physical therapy (PT) can be used for the treatment of chronic obstructive pulmonary disease (COPD). However, its effectiveness is still inconclusive. This systematic review will aim to assess and safety patients with COPD.