A5101714303- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Renal and Vascular Pathologies
- Phytochemistry and Biological Activities
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Natural product bioactivities and synthesis
- Natural Antidiabetic Agents Studies
- Liver Disease and Transplantation
- Essential Oils and Antimicrobial Activity
- Chemical synthesis and alkaloids
- Neurological Complications and Syndromes
- Plant biochemistry and biosynthesis
- Traditional and Medicinal Uses of Annonaceae
- Drug-Induced Hepatotoxicity and Protection
- Sesquiterpenes and Asteraceae Studies
- Cardiac Valve Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Coronary Interventions and Diagnostics
- Studies on Chitinases and Chitosanases
- Pancreatitis Pathology and Treatment
- Mechanical Circulatory Support Devices
- Cholangiocarcinoma and Gallbladder Cancer Studies
Peking University First Hospital
2019-2022
Peking University
2019-2022
Abstract We examined whether the hepatitis B virus (HBV) pregenomic RNA (pgRNA) status after nucleos(t)ide (NA) treatment can predict long‐time prognoses of chronic patients. Patients with (98) who were treatment‐naïve and had begun a 7‐year NA therapy regimen enrolled in this study. Biochemical indicators serological markers HBV infection performed during therapy. pgRNA was quantified by real‐time quantitative PCR specific primers. During treatment, DNA undetectable rates increased. The...
Precocene II (6,7-dimethoxy-2,2-dimethyl-2-chromene) was the main constituent isolated from Ageratum conyzoides L. and reportedly possessed antifungal activity. The study investigated isolation, purification toxicological effects of precocene A. in Sprague Dawley rats. petroleum ether fraction plant structure determined by 1 H-, 13 C-,DEPT-NMR MS spectral techniques. Three groups eight rats per group were used for study. While B C respectively administered with 25 50 mg/kg 0.25% CMC-Na 11...
Abstract Limited data are currently available regarding fibrosis progression after hepatitis C virus (HCV) eradication. The goal of the present study was to evaluate effects HCV eradication on liver stiffness measurements (LSMs), aspartate aminotransferase/platelet ratio index (APRI) scores, fibrosis‐4(FIB‐4) chitinase‐3‐like protein 1 (CHI3L1) levels and Golgi 73 (GP73) in patients with chronic (CHC). One hundred two who received direct antiviral agents (DAAs) therapy at Peking University...
Abstract Background Lipid profiles are declined in patients with viral liver cirrhosis and correlated severity of disease. Hepatitis B virus (HBV) is the leading cause China. Our primary aim was to investigate whether serum lipids lipoproteins associate survival HBV-related acute gastrointestinal bleeding, develop a 6-week mortality risk score that incorporates it. Methods From January 2008 December 2015, consecutive cirrhotic bleeding admitted our hospital were evaluated randomly divided...
The success of direct-acting antivirals (DAAs) against hepatitis C virus is a major breakthrough in hepatology. Previous studies have shown that chitinase 3-like protein 1 (CHI3L1) was marker for staging liver fibrosis caused by HCV. In this investigation, we used CHI3L1 as surrogate to compare dynamic hepatic variations following the elimination HCV among cases receiving sofosbuvir (SOF)-based regimens and pegylated interferon/ribavirin (PR) treatments. study enrolled 105 patients,...
ObjectivesTo investigate the factors and virological significance of serum hepatitis B virus (HBV) pregenomic RNA (pgRNA) status after long-term antiviral therapy with nucleos(t)ide analogues (NAs) in patients chronic (CHB).MethodsIn total, 51 treatment-naïve CHB were included study. Clinical data collected at baseline, during 5 years year 10 NA treatment. Serum HBV pgRNA was determined 5.ResultsAt 5, 45% remained positive for pgRNA. There significant differences baseline e antigen (HBeAg)...
Serum hepatitis B virus pregenomic RNA (HBV pgRNA) is a potential biomarker that correlated with covalently closed circular DNA. The long-term dynamics of HBV pgRNA in patients chronic need to be explored. One hundred naïve nucleos(t)ide analog-treated were enrolled analyze the over 9 years. positive rates pgRNAs declined gradually and showed biphasic kinetics. levels treated entecavir became negative later than those adefovir or lamivudine. Patients who remain for after years treatment may...
Since oral direct-acting antiviral agents (DAAs) became available, the global hepatitis C treatment situation has undergone tremendous changes. However there are still many issues worthy of attention in treatment.We selected 53 HCV-infected patients who were treated and followed up Peking University First Hospital from December 2017 to January 2021 detect RASs HCV. Pearson correlation analysis was used analyze HCV RNA cAg, Fisher exact test chi-square compare effects on rate decline core...
Objective The role of stereotactic body radiation therapy (SBRT) for treating small hepatocellular carcinoma (sHCC) has gained increasing recognition. However, the prognosis and risk factors recurrence in patients with sHCC remain unclear. This study investigated hepatitis B virus (HBV)-related after SBRT. Methods A total 240 HBV-related treated SBRT between March 2011 2020 were retrospectively analyzed. cumulative probability was calculated according to Kaplan–Meier method. Univariate...
Abstract Three new benzoic acid allopyranosides (I) and four lignan glycosides (II)—(IV) are isolated along with five known compounds from the twigs of Chinese conifer mentioned above.
Abstract isolation, structure and biological activities of a new lignan, densispicoside (I), two iridoids, densispicnin C(II) D(III), along with fourteen known compounds
Abstract scurcasinlignan A—D, isolated from aerial parts of the deciduous title plant