A5060308003- MicroRNA in disease regulation
- Microstructure and Mechanical Properties of Steels
- Cancer-related molecular mechanisms research
- Metal Alloys Wear and Properties
- Metallurgy and Material Forming
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Advanced Computational Techniques and Applications
- Hydraulic Fracturing and Reservoir Analysis
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Hydrocarbon exploration and reservoir analysis
- Drilling and Well Engineering
- High-Temperature Coating Behaviors
- Hydrogen embrittlement and corrosion behaviors in metals
- Intraocular Surgery and Lenses
- Laser and Thermal Forming Techniques
- Retinal and Macular Surgery
- Cancer, Hypoxia, and Metabolism
Qinghai University Affiliated Hospital
2022-2025
China Medical University
2019-2025
Guangxi Medical University
2025
Jilin Electric Power Research Institute (China)
2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2019-2024
Griffith University
2023-2024
First Affiliated Hospital of Nanchang University
2021-2024
Nanchang University
2021-2024
Xi'an University of Technology
2024
Yuhuangding Hospital
2021-2024
Abstract We aimed to evaluate the efficacy and safety of adding apatinib, sintilimab chemotherapy in neoadjuvant treatment early triple-negative breast cancer (TNBC). In phase 2 NeoSAC trial, patients with TNBC received six cycles sintilimab, nab-paclitaxel, carboplatin followed by surgery. The primary endpoint was pathological complete response (pCR) rate. Specimens collected pre-neoadjuvant therapy post-surgery were retained for comprehensive analysis predictive biomarkers impact on tumor...
Background: POCD is a common postoperative complication associated with anesthesia and surgery. Its occurrence reduces the quality of life after surgery increases risk death disability. Related studies demonstrated that hyperlipidemia could affect development patients' cognitive dysfunction. However, association between has not been well examined. Methods: A total 98 patients were divided into group normal lipid based on blood level. Minimum Mental State Examination was used to evaluate...
The association between preoperative CT-based sarcopenia and prognosis in locally advanced rectal cancer (LARC) remains unclear. aim of this study was to investigate the relationship clinical outcomes patients with LARC. This multicenter retrospective analyzed 503 LARC who underwent radical resection three tertiary hospitals China from January 2018 June 2021 were pathologically confirmed. All followed for a period at least years. Clinical, pathological, imaging data carefully collected....
Abstract Papillary thyroid carcinoma (PTC) is an aggressive histological subtype of (THCA), whose occurrence rate high. The participation long noncoding RNAs in the pathologies cancers has attracted significant attention during past decades. purpose current study to investigate role NR2F1 antisense RNA 1 (NR2F1‐AS1) PTC. expression THCA samples was analyzed by bioinformatics tool gene profiling interactive analysis. Levels NR2F1‐AS1, microRNA‐423‐5p (miR‐423‐5p), and SRY‐box 12 (SOX12) were...
Abstract Internal tandem duplication (ITD) is the most common type of FLT3 mutation (FLT3-ITD), accounting for about 25% AML patients. The expression DANCR in FLT3-ITD had not been paid attention to, and whether its regulatory relationship with IGF2BP2 can affect progression was unclear. Our study sought to verify biological role as an m6A reading protein AML. To further explore mechanism AML, provide a basis screening biomarkers development targeted drugs. results show that upregulated...
Abstract Patients with head and neck squamous cell carcinoma (HNSCC) are at a high risk of developing recurrence secondary cancers. This study evaluates the prognostic surveillance utilities circulating tumour cells (CTCs) in HNSCC. A total 154 HNSCC patients were recruited followed up for 4.5 years. Blood samples collected baseline follow-up. CTCs isolated using spiral microfluid device. Recurrence death due to cancer assessed during follow-up period. In HNSCC, presence was predictor (OR =...
Formosanin C (FC) isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells animal systems. However, there is no report about its anti-metastatic effect on cancer cells. This research used the wound healing migration assay to detect anti-invasive of FC LA795 Through gelatin zymography immunofluorescence analysis, suppression enzyme MMP-2 MMP-9, protein expression MMP-1, -2, -3, -9 -14 excreted Finally, exhibited much more effective...
MicroRNAs are highly conserved noncoding RNA that negatively modulate protein expression at a posttranscriptional and/or translational level and deeply involved in the pathogenesis of several types cancers. To date, potential microRNAs regulating growth progression osteosarcoma not fully identified yet. Previous reports have shown differentially expressed miR-125b osteosarcoma. However, role human has been totally illuminated. In this study, we was downregulated tissues compared to adjacent...
In the study, we aimed to find key long noncoding RNAs (lncRNAs) significantly associated with diagnosis of colon adenocarcinoma (COAD) and lncRNA signatures provide survival risk prognosis for patients COAD.The messenger RNA (mRNA) expression profiles clinical information COAD were obtained from Cancer Genome Atlas database. The differentially expressed lncRNAs (DElncRNAs) mRNAs (DEmRNAs) between normal tissues identified. optimal diagnostic prognostic biomarkers identified by using feature...
Despite the rising incidence, particularly of human papillomavirus (HPV)-associated fraction oropharyngeal cancer (OPC), there are no early detection methods for OPC. Considering close association between saliva and head neck cancers, this study was designed to investigate salivary micro RNA (miRNAs) associated with OPC, especially focusing on HPV-positive
Previous microRNA (miR) microarray analysis revealed that miR‑218 is downregulated in cervical cancer tissues. The present study aimed to further evaluate the expression of specimens, determine association between its with disease progression, and investigate roles cells. Tissue specimens were obtained from 80 patients squamous cell carcinoma, 30 high‑grade intraepithelial neoplasia [(CIN) II/III] 15 low‑grade CIN (CINI); addition, 60 plasma samples cancer, normal tissue healthy women. These...
Abstract Long non‐coding RNAs (lncRNAs) are a novel class of regulators in multiple cancer biological processes. However, the functions lncRNAs pancreatic ductal adenocarcinoma (PDAC) remain largely unknown. In this study, we identified PWAR6 as frequently down‐regulated lncRNA PDAC samples well panel cell lines. Down‐regulated was associated with clinical outcomes, including advanced tumour stage, distant metastasis, and overall survival patients. our cell‐based assays, ectopic expression...
Local recurrence and metastasis remain the major causes of death in head neck cancer (HNC) patients. Circulating tumour cells (CTCs) are shed from primary metastatic sites into circulation system have been reported to play critical roles HNC. Here, we explored use CTCs predict response treatment disease progression HNC patients.Blood samples were collected at diagnosis patients (n = 119). isolated using a spiral microfluidic device identified immunofluorescence staining. Correlation baseline...