A5101673921- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Cancer Risks and Factors
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- Ubiquitin and proteasome pathways
- Ion channel regulation and function
- Pancreatic function and diabetes
- Estrogen and related hormone effects
- Cell death mechanisms and regulation
- Ovarian cancer diagnosis and treatment
- Autophagy in Disease and Therapy
- Gut microbiota and health
- Histone Deacetylase Inhibitors Research
- Ferroptosis and cancer prognosis
Shanxi Cardiovascular Hospital
2024
Hebei Medical University
2024
Fourth Hospital of Hebei Medical University
2024
Chongqing University of Education
2024
Shandong Tumor Hospital
2015-2023
Shandong First Medical University
2015-2023
First Affiliated Hospital of Nanchang University
2018-2023
Nanchang University
2018-2023
Jiangxi Provincial Cancer Hospital
2023
National Center for Advancing Translational Sciences
2020-2023
The National Center for Advancing Translational Sciences (NCATS) has developed an online open science data portal its COVID-19 drug repurposing campaign - named OpenData with the goal of making across a range SARS-CoV-2 related assays available in real-time. cover wide spectrum life cycle, including both viral and human (host) targets. In total, over 10,000 compounds are being tested full concentration-response ranges from multiple annotated small molecule libraries, approved drug,...
Glutamine is one of the main nutrients used by tumor cells for biosynthesis. Therefore, targeted inhibition glutamine metabolism may have anti-tumorigenic implications. In present study, we aimed to evaluate effects on ovarian cancer cell growth. Three lines, HEY, SKOV3, and IGROV-1, were assayed dependence analyzing cytotoxicity, cycle progression, apoptosis, stress, glucose/glutamine metabolism. Our results revealed that administration increased proliferation in all three lines a dose...
// Jessica E. Stine 1, * , Hui Guo 2, Xiugui Sheng 2 Xiaoyun Han Monica N. Schointuch 1 Timothy P. Gilliam Paola A. Gehrig 3 Chunxiao Zhou 3, # Victoria L. Bae-Jump Division of Gynecologic Oncology, University North Carolina, Chapel Hill, NC, USA Department ShanDong Cancer Hospital & Institute, Jinan University, Jinan, P.R. China Lineberger Comprehensive Center, These authors have contributed equally to this work This was presented at the Society Oncology's Annual meeting on Women's Cancer....
The aim of this study was to evaluate the effect when silencing HOTAIR in ovarian cancer skov3 cells on proliferation, migration, and invasion, elucidate mechanism by which occurs.We detected mRNA level (HOX antisense intergenic RNA) MAPK1 (mitogen-activated protein kinase 1) SKOV3, ES-2, OVCAR3, A2780, COC1 cell lines. We SKOV3 transected with miR-1, miR-214-3p, or miR-330-5p. HOTAIR. expression MAPK1. Then we invasion after MAPK1.The OVCAR3 increased compared A2780 (P<0.05). decreased...
F-box and WD repeat domain-containing 5 (FBXW5), with WD40 repeats, can bind to the PPxY sequence of large tumor suppressor kinases 1/2 (LATS1/2) kinase domain, resulting in ubiquitination. Ubiquitination subsequent degradation LATS1/2 abrogate Hippo pathway worsen gastric cancer (GC). However, effects molecular mechanisms FBXW5 GC remain unexplored. To elucidate clinical significance FBXW5, immunohistochemistry was conducted reveal positive correlation between expression lymph node...
Selenoprotein glutathione peroxidases (GPX), like ubiquitously expressed GPX1 and the ferroptosis modulator GPX4, enact antioxidant activities by reducing hydroperoxides using glutathione. Overexpression of these enzymes is common in cancer can be associated with development resistance to chemotherapy. GPX4 inhibitors have thus shown promise as anti-cancer agents, targeting other GPX isoforms may prove equally beneficial. Existing are often promiscuous, or modulate GPXs only indirectly, so...
// Haifeng Qiu 1, 2 , Jing Li 3 Leslie H. Clark Amanda L. Jackson Lu Zhang 2, 4 Hui Guo Joshua E. Kilgore Paola A. Gehrig Chunxiao Zhou 5 Victoria Bae-Jump 1 Department of Obstetrics and Gynecology, the First Affiliated Hospital Zhengzhou University, Zhengzhou, China Division Gynecological Oncology, University North Carolina at Chapel Hill, NC, USA Gynecologic Shandong Cancer Institute, Jinan, Lineberger Center, Correspondence to: Bae-Jump, email: vbae@unch.unc.edu Zhou, czhou@med.unc.edu...
// Li Sun 1, 3, * , Yajie Yin 2, Leslie H. Clark 3 Wenchuan Stephanie A. Sullivan Arthur-Quan Tran Jianjun Han 4 Lu Zhang 1 Hui Guo Esther Madugu Tommy Pan Amanda L. Jackson 5 Joshua Kilgore 6 Hannah M. Jones Timothy P. Gilliam Chunxiao Zhou 7 and Victoria Bae-Jump Department of Gynecologic Oncology, Shandong Cancer Hospital Affiliated to University, Academy Medical Sciences, Jinan, Province, People's Republic China 2 School Medicine Life University Division North Carolina at Chapel Hill,...
The Yes-associated protein (YAP1) is a main effector of the canonical Hippo pathway, which contributes greatly to tumor initiation, progression, and metastasis in multiple cancers, including gastric cancer (GC). Due limited knowledge YAP1 upregulation cancer, it great challenge therapeutic targets toward Hippo–YAP1 pathway. Here, we identify nucleolar spindle-associated 1 (NUSAP1) as novel binding partner YAP1. NUSAP1 associated with unfavorable clinical outcomes GC patients, depletion...
The Wilms' tumor-associated gene WT1 encodes a tumor suppressor gene, which is implicated in renal differentiation and development of adult urogenital system. 1-associating protein (WTAP) initially identified as nuclear that specifically interacts with both vitro vivo assays. WTAP ubiquitously expressed different tissues various growth periods, its expression involved cell cycle, RNA splicing stabilization, N6-methyladenosine modification, proliferation, apoptosis well embryonic development....
Abnormal changes in body composition and systemic inflammation response have been associated with poor survival of cancer patients. Our study was to explore the prognostic value association between indicators markers among patients locally advanced cervical (LACC) who underwent concurrent chemoradiotherapy (CCRT).We retrospectively reviewed medical records LACC treated 2016 2019. Subcutaneous, visceral intra-muscular adipose index (SAI, VAI IMAI) skeletal muscle (SMI) were derived from...
Emerging evidence indicates that Akkermansia muciniphila (AKK) may be a potential probiotic agent for ameliorating colorectal cancer (CRC). Thus, we utilized the azoxymethane (AOM)/ dextran sodium sulfate (DSS)-induced mouse model of to evaluate intervention effect AKK PROBIO. The results showed PROBIO significantly improved colon health, decreased serum pro-inflammatory cytokines levels, as well downregulated mRNA levels p50, p52, p65, and IκBβ, upregulated expressions Bid, Bim, caspase-9...
We found that tetrandrine (TET) can reverse the resistance of Candida albicans to fluconazole (FLC) and this interaction is associated with inhibition drug efflux pumps. Mitochondrial aerobic respiration, which plays a major role in C. metabolism, primary source ATP for cellular processes, including activation However, it was unclear if TET exerts its synergistic action against via impact on mitochondrial respiratory metabolism. To investigate mechanism, we examined FLC presence or absence...
Accuracy of prediction pelvic lymph node status using sentinel biopsy (SLNB), and outcomes SLNB-guided abdominal radical trachelectomy (ART) were assessed. Patients with stage IB1 (Figure 2009) cervical cancer tumors >2 cm enrolled. Prior to fertility-sparing surgery 99mTc-labeled phytate was administered. SLNs intraoperatively identified, excised, assessed fast-frozen sections. Systematic bilateral lymphadenectomy or without para-aortic subsequently undertaken. The SLN detection rate 91.8%...
Obesity and diabetes have been associated with increased risk worse outcomes in ovarian cancer (OC). The biguanide metformin is used the treatment of type 2 also believed to anti-tumorigenic benefits. Metformin highly hydrophilic requires organic cation transporters (OCTs) for entry into human cells. Phenformin, another biguanide, was taken off market due an lactic acidosis over metformin. However, phenformin not reliant on cell entry; thus, may potency as both anti-diabetic agent than Thus,...
Accumulating evidence has highlighted the critical role of cullin 4B (CUL4B) in driving tumourigenesis several malignancies, including gastric cancer (GC); however, mechanisms underlying CUL4B upregulation remain unclear. The dysregulation microRNAs (miRNAs or miRs) is known to be involved tumourigenesis. In this study, we report that expression miR‑381 and miR‑489 downregulated negatively correlated with GC tissues cell lines. Further analysis verified directly targeted CUL4B. silencing...