A5074712841- Endometrial and Cervical Cancer Treatments
- Metabolism, Diabetes, and Cancer
- Ovarian cancer diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Uterine Myomas and Treatments
- Ethics in Clinical Research
- Cervical Cancer and HPV Research
- Diversity and Career in Medicine
- Cancer Risks and Factors
- Health and Medical Research Impacts
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Amino Acid Enzymes and Metabolism
- BRCA gene mutations in cancer
- Peroxisome Proliferator-Activated Receptors
- Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Prenatal Screening and Diagnostics
- Surgical Simulation and Training
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Venous Thromboembolism Diagnosis and Management
- Beetle Biology and Toxicology Studies
Northwestern University
2022-2025
Northwestern Medicine
2023
Northwestern Memorial Hospital
2023
University of North Carolina at Chapel Hill
2014-2021
University of Maryland, Baltimore
2020
Brown University
2013-2018
Women & Infants Hospital of Rhode Island
2012-2018
UNC Lineberger Comprehensive Cancer Center
2016
University of North Carolina Hospitals
2014-2015
University of North Carolina Health Care
2014
Glutamine is one of the main nutrients used by tumor cells for biosynthesis. Therefore, targeted inhibition glutamine metabolism may have anti-tumorigenic implications. In present study, we aimed to evaluate effects on ovarian cancer cell growth. Three lines, HEY, SKOV3, and IGROV-1, were assayed dependence analyzing cytotoxicity, cycle progression, apoptosis, stress, glucose/glutamine metabolism. Our results revealed that administration increased proliferation in all three lines a dose...
Clinical trials guide evidence-based obstetrics and gynecology (OB-GYN) but often enroll nonrepresentative participants.To characterize race ethnicity reporting representation in US OB-GYN clinical their subsequent publications to analyze the association of subspecialty funding with diverse representation.Cross-sectional analysis all studies registered on ClinicalTrials.gov (2007-2020) from PubMed Google Scholar (2007-2021). Analyses included logistic regression controlling for year,...
Telomerase activity and expression of the catalytic protein hTERT are associated with cell proliferation advanced stage in endometrial cancer. Our objective was to evaluate effect inhibition by siRNA BIBR1532 on growth, apoptosis invasion cancer cells. Knockdown or treatment cells decreased telomerase activity, inhibited proliferation, induced apoptosis, reduced Ishikawa ECC-1 Either combination paclitaxel promoted a synergistic inhibitory growth through induction Annexin V remarkable...
PURPOSE The objective of this study was to test the feasibility implementing a postoperative monitoring program for women with gynecologic cancers composed patient-reported outcomes (PROs) and wearable activity monitor. METHODS We prospectively enrolled patients undergoing cancer surgery single-arm study. Enrolled completed PROs (Patient-Reported Outcomes Measurement Information System physical function, sleep disturbance, anxiety, fatigue, pain intensity) at baseline one-week intervals 4...
We aimed to compare progression-free survival (PFS) and overall (OS) among patients with stage I-to-IV uterine leiomyosarcoma (uLMS) who received adjuvant gemcitabine-docetaxel, were observed, radiation only, or treated a chemotherapy regimen other than gemcitabine-docetaxel.This is retrospective cohort study of 128 women uLMS. Data included age, body mass index, race, stage, mitotic count, residual disease, treatment, PFS, OS. Variables compared by Fisher exact Wilcoxon rank-sum tests. Time...
Anemia is prevalent in patients with gynecologic cancers and associated increased peri-operative morbidity. We aimed to characterize risk factors for pre-operative anemia describe outcomes among undergoing surgery by a oncologist identify potential areas impactful intervention.
Sutures, hemoclips, and electrocautery are the primary mechanisms used to achieve hemostasis during gynecologic surgery, but in situations which these inadequate or not feasible, an array of hemostatic agents available help hemostasis. These include physical such as cellulose, collagen, gelatin products well biologic thrombin fibrin products. Limited data on many agents, although their use is increasing, sometimes at high costs. In likely most effective when areas oozing slow bleeding...
Inclusive clinical trials are necessary to improve maternal health equity. We aimed analyze the current state of race and ethnicity reporting representation in obstetric association with trial focus for all U.S.-based between 2007 2020. In this cross-sectional, multivariable regression analysis, exposure variable was (eg, prematurity), outcomes were diverse cohorts. Obstetric anesthesia reported least frequently foci (adjusted odds ratio 0.2, 95% CI 0.08-0.48). Hypertension enrolled lowest...
Objectives Anti-diabetic biguanide drugs such as metformin may have anti-tumorigenic effects by behaving AMPK activators and mTOR inhibitors. Metformin requires organic cation transporters (OCTs) for entry into cells, NT-1044 is an activator designed to greater affinity two of these transporters, OCT1 OCT3. We sought compare the on cell proliferation in human endometrial cancer (EC) lines tumor growth endometrioid EC mouse model. Methods Cell was assessed lines, ECC-1 Ishikawa, MTT assay...
Introduction Among all cancers, endometrial cancer is most strongly associated with obesity, more than 65% of cancers attributable to obesity and being overweight. Fatty acid synthase (FAS), a key lipogenic enzyme, expressed in tumors worse prognosis for this disease. Orlistat, an FAS inhibitor, FDA-approved weight loss medication that has demonstrated anti-tumor activity variety preclinical models. Methods In study, the Lkb1 fl/fl p53 mouse model endometroid was exposed three diet...
REGN5668 (R5668) is a mucin16 (MUC16) x CD28 bispecific antibody (bsAb). R5668 provides "signal 2" T-cell costimulation through in the presence of MUC16 tumor antigen. bispecifics augment anti-tumor activity anti-PD-1 monoclonal Ab cemiplimab (cemi) preclinical studies. We present phase 1 dose-escalation results intravenous (IV) combined with cemi patients (pts) recurrent platinum-experienced ovarian cancer (OC). Pts received weekly IV at dose range 0.3-300 mg. Cemi 350 mg every 3 weeks was...