A5038121350- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Metabolism, Diabetes, and Cancer
- Cancer, Stress, Anesthesia, and Immune Response
- RNA modifications and cancer
- CAR-T cell therapy research
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- PARP inhibition in cancer therapy
- Fatty Acid Research and Health
- Peroxisome Proliferator-Activated Receptors
- Immunotherapy and Immune Responses
- Phytochemical Studies and Bioactivities
- Phytochemistry and Bioactive Compounds
- Hormonal Regulation and Hypertension
- Histone Deacetylase Inhibitors Research
- PI3K/AKT/mTOR signaling in cancer
Daqing Normal University
2025
Stanford University
2021-2024
Gladstone Institutes
2022-2023
University of North Carolina at Chapel Hill
2017-2023
Wuhan Union Hospital
2023
Parker Institute for Cancer Immunotherapy
2023
Palo Alto University
2022
University of Jinan
2015-2017
Shandong Tumor Hospital
2016-2017
Shandong First Medical University
2015-2017
The autoimmune regulator (Aire), a well-defined transcriptional in the thymus, is also found extrathymic Aire-expressing cells (eTACs) secondary lymphoid organs. eTACs are hematopoietic antigen-presenting and inducers of immune tolerance, but their precise identity has remained unclear. Here, we use single-cell multiomics, transgenic murine models, functional approaches to define at transcriptional, genomic, proteomic level. We find that consist two similar cell types: CCR7+ migratory...
<p>Differential expression analysis of rejected vs. non-rejected tumor cells.</p>
<p>Supplementary data linked to the in vivo CRISPR screen.</p>
<p>Cell types from scRNA-seq of tumors mice inoculated with rejected or non-rejected SCCs.</p>
<p>Evaluation of Mif expression in stromal cells, and its effect on patient survival.</p>
<p>Analysis of tissue microarray biopsies from cancer patients.</p>
<p>CyTOF analysis comparing tumors derived from Mif WT and KO validating the scRNAseq findings.</p>
<p>Highest Mif expression was found in tumor cells, compared to other cell types.</p>
<p>Immunopeptidomics and TCR sequencing analyses showed similar results for the rejected non-rejected SCCs.</p>
<div>Abstract<p>Low intratumor heterogeneity correlates with increased patient survival and immunotherapy response. However, even highly homogeneous tumors are variably aggressive, the immunologic factors impacting aggressiveness remain understudied. In this study, we analyzed mechanisms underlying immune escape in murine low heterogeneity. We used immunophenotyping single-cell RNA sequencing to compare temporal growth of <i>in vivo</i> transplanted, genetically...
<p>Clinical data and characterization of the single-cell clones.</p>
<p>Opal and CODEX multiplexed tissue imaging data shows infiltration of proliferative CD8+ T-cells to the rejected SCCs.</p>