A5008782959- CAR-T cell therapy research
- Nanowire Synthesis and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Cell Function and Interaction
- Advancements in Semiconductor Devices and Circuit Design
Stanford University
2022-2025
SUMMARY Arming T cells with a synthetically orthogonal IL-9 receptor (o9R) permits facile engraftment and potent anti-tumor functions. We considered whether the paucity of natural IL-9R expression could be exploited for cell immunotherapy given that, in mice, high doses were well-tolerated without discernible immune modulation. Compared to o9R, engineered exhibit superior tissue infiltration, stemness, activity. These qualities are consistent stronger JAK/STAT signal, which addition...
Introductory paragraph While CAR T cells have altered the treatment landscape for B cell malignancies, risk of on-target, off-tumor toxicity has hampered their development solid tumors because most target antigens are shared with normal 1,2 . Researchers attempted to apply Boolean logic gating prevent 3–7 ; however, a truly safe and effective logic-gated remained elusive 8 Here, we describe novel approach engineering in which replace traditional ITAM-containing CD3ζ domains intracellular...