A5068596690- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- Brain Metastases and Treatment
- SARS-CoV-2 and COVID-19 Research
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Physical Education and Pedagogy
- Lymphadenopathy Diagnosis and Analysis
- Inflammatory mediators and NSAID effects
- Geology and Paleoclimatology Research
- Education, Achievement, and Giftedness
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Natural product bioactivities and synthesis
- Global Cancer Incidence and Screening
- Motivation and Self-Concept in Sports
- Eicosanoids and Hypertension Pharmacology
Ningxia Medical University General Hospital
2012-2025
Ningxia Medical University
2012-2025
Yunnan Agricultural University
2023-2025
Guangxi University
2023
China University of Geosciences (Beijing)
2022-2023
China West Normal University
2023
Jilin Agricultural University
2022
Ningbo University Affiliated Hospital
2022
Ningbo University
2022
Northeastern University
2022
PURPOSE The effects of metronomic chemotherapy plus endocrine therapy have yet to be elucidated through a randomized phase III clinical trial. METHODS Randomized trials were conducted at 12 centers in China from August 22, 2017, September 24, 2021, and the final follow-up date was 25, 2023. Patients with hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative metastatic breast cancer (MBC) who had no previous systemic setting enrolled. Participants 1:1 assigned...
Abstract We aimed to evaluate the efficacy and safety of adding apatinib, sintilimab chemotherapy in neoadjuvant treatment early triple-negative breast cancer (TNBC). In phase 2 NeoSAC trial, patients with TNBC received six cycles sintilimab, nab-paclitaxel, carboplatin followed by surgery. The primary endpoint was pathological complete response (pCR) rate. Specimens collected pre-neoadjuvant therapy post-surgery were retained for comprehensive analysis predictive biomarkers impact on tumor...
Background: Centranthera grandiflora Benth is commonly utilized in China to take advantage of its purported health benefits. Methods: Here, the chemical composition, nutritional value, and bioactivity C. extract (CGE) are characterized, mechanisms through which it functions were explored. Results: CGE was found exhibit a favorable biosafety profile, especially due high amino acid mineral contents. A UPLC-ESI-Q-TOF/MS approach identified 20 compounds. Through network pharmacology analyses,...
With the growth of user-generated contents on Web, product reviews opinion mining increasingly becomes a research practice great value to e-commerce, search and recommendation. Unfortunately, number is rising up hundreds or even thousands, especially for some popular items, which makes it laborious work potential buyers manufacturers read through them make wise decision. Besides, free format uncertainty expressions, fine-grained features extraction categorization more difficult task than...
Objective This study aimed to explore possible associations between molecular subtypes and site of distant metastasis in advanced breast cancer (ABC). Methods 3577 ABC patients were selected from 21 hospitals seven geographic regions China 2012-2014. A questionnaire was designed collect medical information regarding demographic characteristics, risk factors, subtype, recurrence/metastasis information, disease-free survival (DFS). The cancers classified into Luminal A, B, HER2-enriched Triple...
Objective: This study determined the cut-off value of Ki-67 expression and discussed interaction between histological grade, further explored prognostic role in hormone receptor-positive human epidermal growth factor receptor 2 negative (HR+/HER2-) breast cancer;. Materials Methods:We assessed 956 patients with HR+/HER2 cancer diagnosed General Hospital Ningxia Medical University from 2015 to 2019 by immunohistochemistry (IHC), The disease-free survival (DFS) was defined as time...
The expectancy-value motivation theory postulates that can be achieved when perceived values in an activity override cost of the derived from effort achieving. This study was designed to examine types physical education and extent which might affect motivation. Data about attainment, intrinsic, utility were collected using surveys college students ( n = 368) China. Perceived investigated through open-ended written responses interviews. Disappointment curriculum emerged as a major lack...
In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were herein identified a novel gradient high-performance liquid chromatography (HPLC) protocol. Further characterization of these was then performed via chromatography–mass spectroscopy (LC–MS/MS) and nuclear magnetic resonance (NMR) approaches. For analyses, commercial STHCl samples used for quantitative HPLC studies the degradation under acidic (1M HCl), alkaline NaOH), oxidative (30% H2O2), photolytic...
PURPOSE We aim to determine the effectiveness of adding electroacupuncture standard triple antiemetic therapy for treating chemotherapy-induced nausea and vomiting (CINV). METHODS From March 2022 December 2023, a randomized, blind, sham-controlled trial conducted across six Chinese hospitals investigated patients with breast cancer undergoing highly emetogenic chemotherapy (HEC). Patients were randomly assigned either true (n = 120) or sham 119) groups, both groups receiving therapy. The...
The expectancy-value theory postulates that motivation relies on individuals' beliefs of success, perceived Attainment, Intrinsic Interest, and Utility values Cost. This study examined Chinese college students' in relation to physical education self-initiated activity.A random sample 368 university students responded questionnaires expectancy beliefs, values, cost terms their experiences mandatory programs after-school activity. They reported choice decisions for continuing education. Data...
S-phase kinase-associated protein 2 (SKP2), a potent oncogene was revealed to be upregulated in gastric cancer (GC) tissue samples, which SKP2 inversely correlated with microRNA (miR)‑508‑5p transcripts. In present study, the functional effect of miR‑508‑5p on and its metastatic potential were investigated SGC‑7901 GC cells. Significant downregulation transcript associated progression GC. Furthermore, overexpression demonstrated inhibit proliferation, migration invasion cells, as well...
Although receptor status including estrogen (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) of the primary breast tumors was related to prognosis cancer patients, little information is yet available on whether patient management survival are impacted by conversion in metastases. Using data from nation-wide multicenter clinical epidemiology study advanced China (NCT03047889), we report situation retesting ER, PR HER2 for metastases evaluate prognostic value conversion. In...
Owing to the complex and long-term treatment of foot wounds due diabetes limited mobility patients, advanced clinical surgery often uses wearable flexible devices for auxiliary treatment. Therefore, there is an urgent need self-powered biomedical reduce extra weight. We have prepared electrically stimulated MEMS (Micro Electromechanical System) electrode integrated with OPV (Organic photovoltaic). The constructed a bio-affinity PET-ITO substrate hundred-nanometer organic layer. Under...
Introduction Invasive micropapillary carcinoma (IMPC) treatment only relies on the standard of nonspecific invasive breast cancer (NSIBC), and it remains controversial whether survival patients improves. Therefore, this study aimed to analyze clinicopathological features IMPC investigate factors affecting its prognosis. Material methods This retrospective cohort included 104 who met study’s inclusion criteria out a total 4,532 with between January 2015 December 2019. A contemporaneous 230...
1081 Background: The primary treatment for brain metastases in patients with HER2-negative advanced breast cancer is predominantly local therapies like radiotherapy, owing to the limited efficacy of systemic therapies. Prior research has demonstrated utidelone's significant permeability across blood-brain barrier and preliminary effectiveness bevacizumab metastases. Consequently, this study investigated safety utidelone combined Methods: This was a single-arm, multi-center phase II clinical...
Breast cancer (BC) is the most diagnosed worldwide, and patients' survival decreases with metastasis. We conducted a retrospective study using data derived from Surveillance, Epidemiology, End Results (SEER) database clinicopathological to construct clinical predictive model predict risk prognosis of lung metastasis (LM) in patients different subtypes BC validate its performance. A total 1650 SEER between 2011 2015 were enrolled this study. Cox regression analysis was performed identify...