A5103008911- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Regulation of Appetite and Obesity
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Spinal Cord Injury Research
- Cancer, Stress, Anesthesia, and Immune Response
- Nerve injury and regeneration
- Protein Interaction Studies and Fluorescence Analysis
- Alcohol Consumption and Health Effects
Henan Cancer Hospital
2014-2025
Cangzhou Central Hospital
2025
Guangzhou University of Chinese Medicine
2025
Central South University
2016-2024
Second Xiangya Hospital of Central South University
2016-2024
University of Louisville
2010-2024
Qinghai University Affiliated Hospital
2024
Xiangyang Central Hospital
2024
Huazhong University of Science and Technology
2010-2023
Union Hospital
2010-2023
Macrophage-targeting therapies have become attractive strategies for immunotherapy. Deficiency of MARCO significantly inhibits tumor progression and metastasis in murine models pancreatic cancer. However, the role patients with cancer remains unclear. In present study, we analyzed tumor-associated macrophage (TAM)-related changes using Cancer Genome Atlas database. We observed a significant enrichment M2 macrophages tissues. found that several pro-tumor markers are increased tissues,...
P2X7 is important in inflammation and tissue injury. The aim of the present study was to investigate effect inhibition, using a specific inhibitor (A438079) prevent development liver injury fibrosis mouse model fibrosis. induced by carbon tetrachloride (CCl4). Mice received subcutaneous administration vehicle (saline/olive oil), CCl4 or A438079. pro‑inflammatory pro‑fibrotic factors were determined western blot analysis. biochemistry, histopathology, collagen deposition nuclear factor‑κB...
Objective This study aimed to explore possible associations between molecular subtypes and site of distant metastasis in advanced breast cancer (ABC). Methods 3577 ABC patients were selected from 21 hospitals seven geographic regions China 2012-2014. A questionnaire was designed collect medical information regarding demographic characteristics, risk factors, subtype, recurrence/metastasis information, disease-free survival (DFS). The cancers classified into Luminal A, B, HER2-enriched Triple...
Invasion and metastasis is the main causes leading to death of hepatocellular carcinoma (HCC) patients. However, underlying mechanism still be explored. Transforming growth factor β1 (TGF-β1) a stronger inducer HCC cell invasion. downstream effector TGF-β1 that promotes invasion unknown. In this study, we found PI3K/Akt activation takes place following stimulation TGF-β1. The inhibition abolished epithelial-mesenchymal transition (EMT) cells induced by Myocyte enhancer factors 2 (MEF2)...
Myeloid cells comprise up to 50% of the total tumor mass in glioblastoma (GBM) and have been implicated promoting progression immunosuppression. Modulating response myeloid has emerged as a promising new approach for cancer treatment. In this regard, we focus on Triggering Receptor Expressed Cells 2 (TREM2), which recently novel immune modulator peripheral tumors.
Introduction Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating condition with no specific treatment. Inhibiting osteocyte apoptosis may be promising therapeutic approach. Shengxue Busui Decoction (SBD) has shown protective effects against SONFH, but its mechanisms are not fully understood. This study aims to investigate SBD on SONFH in rats, identifying key active components and regulatory using network pharmacology, bioinformatics, machine learning, experimental...
585 Background: Conversion or downstaging therapy for intermediate and advanced unresectable hepatocellular carcinoma (HCC) has emerged as a significant exploring area of clinical practice research in recent years. Nonetheless, there exists considerable variability both the selection criteria patients undergoing conversion regimens selected across different regions medical institutions. The present study aims to elucidate current application China, well identify considerations that...
Abstract Background Hemiplegia, a common neurological consequence of moderate to severe traumatic brain injury (TBI) significantly impacts patients' motor and daily living functions. In China, standard treatments for hemiplegia include physical rehabilitation traditional acupuncture. Scalp acupuncture, rooted in Chinese medicine, has gained attention as potential alternative. This study compared the efficacy scalp acupuncture combined with conventional therapy versus alone improving limb...
Accurate and precise measurement of GFR is important for patients with chronic kidney disease (CKD). Sampling time exogenous filtration markers may have great impact on measured (mGFR) results, but there still uncertainty about optimal timing plasma clearance in advanced CKD, whom 24-h recommended. This satellite project the Berlin Initiative Study evaluates whether iohexol reveals a clinically relevant difference compared 5-h older adults.In 104 participants mean age 79 years diagnosed we...
Paeoniflorin exhibits anticancer, anti-inflammatory and antioxidation effects, as well specific pharmacological effects on smooth muscle the immune, cardiovascular central nervous systems. The present study aimed to investigate anticancer of paeoniflorin pancreatic cancer cells elucidate mechanisms by which these occur. In study, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide lactate dehydrogenase assays were performed assess cell viability cytotoxicity BXPC-3 human cells,...
Many basic characteristics of gustatory neurons remain unknown, partly due to the absence specific markers. Some in geniculate ganglion project taste regions oral cavity, whereas others innervate outer ear. We hypothesized that transcription factor Phox2b would identify cavity-projecting ganglion. To test this possibility, we characterized mice which Phox2b-Cre mediated gene recombination labeled with tdTomato. Nerve labeling revealed all projecting through chorda tympani (27%) and greater...
Hepatic stellate cells (HSCs) are the key effector mediating occurrence and development of liver fibrosis, while aerobic glycolysis is an important metabolic characteristic HSC activation. Transforming growth factor-β1 (TGF-β1) induces a driving factor for reprogramming. The depends on high glucose uptake level. Glucose transporter 1 (GLUT1) most widely distributed in body mainly participates regulation carbohydrate metabolism, thus affecting cell proliferation growth. However, little known...
Hepatocellular carcinoma (HCC) is one of the most common and fatal tumors in world, ranking third cancer-related mortality. Chronic HBV infection major risk factors for hepatocellular China, Korea, Sub-Saharan Africa. The HBx protein encoded by X gene a broadly regulated involved transcriptional activation, epigenetics, apoptosis, DNA repair, other regulatory processes. This study aimed to investigate mechanism regulation miR-155 PTEN (Phosphatase tensin homolog deleted on chromosome ten)...