A5050329958- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Statistical Methods in Clinical Trials
- Retinoids in leukemia and cellular processes
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
- RNA Research and Splicing
- Renal cell carcinoma treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
The contribution of hepatitis B virus (HBV) and C (HCV) to primary liver cancer (PLC) their association with aggressiveness remains uncertain in China, a country half global PLC. We aimed characterize this using data from four representative medical centers.In total, 15,801 PLC patients were enrolled the centers distributed Easter5n, Southern, Northern, Western China 2003 2020. Of those, 7585 curative surgery involved survival analysis. A nomogram was constructed preoperative parameters...
585 Background: Conversion or downstaging therapy for intermediate and advanced unresectable hepatocellular carcinoma (HCC) has emerged as a significant exploring area of clinical practice research in recent years. Nonetheless, there exists considerable variability both the selection criteria patients undergoing conversion regimens selected across different regions medical institutions. The present study aims to elucidate current application China, well identify considerations that...
There is little evidence regarding the optimal surgical sequence for colorectal cancer liver metastasis (CRLM) patients undergoing resection with simultaneous resection. CRLM from five centers were retrospectively evaluated. The short-term outcomes included intraoperative and postoperative outcomes. Postoperative complications measured according to Clavien–Dindo classification. Grade I II defined as minor complications. long-term progression-free survival (PFS) overall (OS). Propensity score...
Liquid–liquid phase separation has emerged as a crucial mechanism driving the formation of membraneless biomolecular condensates, which play important roles in numerous cellular processes. These found both nucleus and cytoplasm, are formed through multivalent, low-affinity interactions between various molecules. P62-containing condensates serve, among other functions, proteolytic hubs for ubiquitin–proteasome system. In this study, we investigated dynamic interplay nuclear p62 promyelocytic...
Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options lacking, resulting in a poor prognosis. Over the past few years, combination immune checkpoint inhibitors and anti-angiogenic targeted therapy has proven highly efficacious treating HCC, significantly extending patients' survival providing potential sequential curative surgery. After hepatectomy or liver transplantation following conversion therapy, patients can...