A5050568162- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- COVID-19 and healthcare impacts
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Viral-associated cancers and disorders
- Metabolism, Diabetes, and Cancer
Guangdong Academy of Medical Sciences
2015-2024
Southern Medical University
2017-2024
Guangdong Provincial People's Hospital
2008-2024
Shantou University
2020-2021
Shantou University Medical College
2020-2021
South China University of Technology
2020
Guangdong General Hospital
2010-2019
Sun Yat-sen Memorial Hospital
2015
Sun Yat-sen University
2015
BACKGROUND Orderly G2/M transition in the cell cycle is controlled by cyclin-dependent kinase 1/cyclin B (CDK1/CCNB) complex. We aimed to comprehensively investigate roles of CDK1, CCNB1, and CCNB2 via multi-omics analysis their relationships with immune infiltration hepatocellular carcinoma (HCC). MATERIAL AND METHODS The transcriptional data epigenetic genetic alterations CCNB2, as well impacts on prognosis HCC patients, were identified using multiple databases. correlations between...
Abstract Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide, epithelial–mesenchymal transition (EMT) a crucial factor affecting HCC progression metastasis. Long noncoding RNAs (lncRNAs) have been validated to act as critical regulators biological processes in various tumors. Herein, we attempted elucidate uncharacterized function mechanism lncRNA DLGAP1-AS1 regulating tumorigenesis EMT HCC. In our study, was shown be upregulated cell lines capable...
Background: N6-methyladenosine (m6A) is the most prevalent modification of mammalian RNA. Emerging evidence suggest that m6A has critical roles in multiple biological activities, but little known about its cancer pathogenesis. Herein, we report expression profiles and prognostic relevance twelve m6A-related genes hepatocellular carcinoma (HCC) by analyzing four independent datasets. Materials methods: RNA levels were detected samples 162 HCC patients who underwent curative resection (the...
With the rapid progress of systematic therapy for hepatocellular carcinoma (HCC), therapeutic strategies combining hepatic arterial infusion chemotherapy (HAIC) with arised increasing concentrations. However, there have been no review comparing HAIC and its combination in first-line treatment advanced HCC.
Abstract Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by autoreactive T cell response against intrahepatic small bile ducts. Here, we use Il12b -/- Il2ra mice (DKO mice) as model of and demonstrate that Cd8a knockout or treatment with an anti-CD8α antibody prevents/reduces immunopathology. Using single-cell RNA sequencing analysis, identified CD8 + tissue-resident memory (Trm) cells in the livers DKO mice, which highly express activation-...
Indocyanine green fluorescence-guided laparoscopic hepatectomy (ICG-guided LH) is increasingly used for the treatment of hepatocellular carcinoma (HCC). However, whether ICG-guided LH can improve surgical outcomes remains unclear. This study aimed to investigate short-term and survival versus common (CLH) HCC.We conducted a retrospective analysis 104 158 CLH patients from 2014 2020 at our center. To avoid selection bias, 81 cases were analyzed after 1:1 propensity score matching (PSM). The...
Background/aim: Increasing evidence show microRNAs (miRNAs) are engaged in hepatocellular carcinoma (HCC). The aim of this study was to investigate the role miR-144 HCC, as well identify its underlying mechanism. Methods: expression levels were assessed multiple HCC cell lines, liver tissues from patients with HCC. We further examined effects on molecular target identified using a computer algorithm and confirmed experimentally. Results: found that frequently downregulated human...
Alternative splicing (AS) has a critical role in tumor progression and prognosis. Our study aimed to investigate pancreatic cancer-specific AS events using RNA-seq data, gaining systematic insights into potential prognostic predictors. We downloaded 10623 genes with 45313 from the Cancer Genome Atlas (TCGA) SpliceSeq database. Cox univariate analyses of overall survival suggested there was remarkable association between 6711 cancer patients (P<0.05). The area under curves receiver operator...
BACKGROUND:The right area and posterior of the liver are considered relatively unfavorable portions for laparoscopic hepatectomy (LH) due to limited gross inspection poor tactile feedback. Fusion indocyanine green fluorescence fusion imaging (ICGFI) may be a reliable real-time navigation tool LH. The aim present study was evaluate usefulness ICGFI non-anatomical in patients with hepatocellular carcinoma at area. MATERIAL AND METHODS:We conducted retrospective comparison surgical...
Background/aim: Increasing evidences show that microRNAs are engaged in hepatocellular carcinoma (HCC). The aim of this study was to investigate the role miR-502-3P HCC and identify its underlying mechanism. Methods: expression levels were assessed multiple cell lines liver tissues patients with HCC. We further examined effects on malignant behavior molecular target identified using a computer algorithm confirmed experimentally. Results: Downregulation found both human samples....
To investigate the function of discoidin domain receptor 1 (DDR1) in hepatocellular carcinoma (HCC) and to further clarify underlying mechanism.
Our study aimed to identify inflammatory biomarkers and develop a prediction model stratify high-risk patients for hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) recurrence after curative resection.A total of 583 eligible HBV-HCC with hepatectomy from Guangdong Provincial People's Hospital (GDPH) Sun Ya-sen University Cancer Centre (SYSUCC) were enrolled in our study. Cox proportional hazards regression was utilized evaluate potential risk factors disease-free survival...
Circular RNA (circRNA) plays a critical role in tumorigenesis and tumor progression. Many studies indicate that circRNA Gprc5a is significantly upregulated functions as an oncogene variety of cancers. However, the molecular mechanism circGprc5a liver cancer remains unclear.qRT-PCR was used to measure expression levels circGprc5a, miR-1283, YAP1 TEAD1 mRNA hepatocellular carcinoma (HCC) tissues or cells. protein were detected by Western blot. CCK-8 assay, cell colony formation, BrdU...
Abstract Background Hepatocellular carcinoma (HCC) is the most common cancer with limited cure and poor survival. In our study, a bioinformatic analysis was conducted to investigate role of glycolysis in pathogenesis progression HCC. Methods Single‐sample gene set enrichment (ssGESA) used calculate scores for each sample TCGA‐LIHC GEO14520 according set. Weighted co‐expression network identified module closely related glycolysis, their function investigated. Prognostic biomarkers were...
Hepatocellular carcinoma (HCC), an aggressive malignant tumor, has a high incidence and unfavorable prognosis. Recently, the synergistic effect of pyroptosis in antitumor therapy regulation tumor immune microenvironment made it possible to become novel therapeutic method, but its potential mechanism still needs further exploration. Differentially expressed genes with prognostic value Liver Carcinoma Project The Cancer Genome Atlas (TCGA-LIHC) cohort were screened incorporated into risk...