A5068016013- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Inflammatory Biomarkers in Disease Prognosis
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
- Lung Cancer Research Studies
- Biliary and Gastrointestinal Fistulas
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Minimally Invasive Surgical Techniques
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
Guangdong Provincial People's Hospital
2008-2023
Guangdong Academy of Medical Sciences
2010-2023
South China University of Technology
2020
Southern Medical University
2015-2020
Guangdong General Hospital
2010-2019
Zhujiang Hospital
2015
BACKGROUND Orderly G2/M transition in the cell cycle is controlled by cyclin-dependent kinase 1/cyclin B (CDK1/CCNB) complex. We aimed to comprehensively investigate roles of CDK1, CCNB1, and CCNB2 via multi-omics analysis their relationships with immune infiltration hepatocellular carcinoma (HCC). MATERIAL AND METHODS The transcriptional data epigenetic genetic alterations CCNB2, as well impacts on prognosis HCC patients, were identified using multiple databases. correlations between...
Abstract Background. The EACH study assessed the efficacy of oxaliplatin, 5-fluorouracil, and leucovorin (the FOLFOX4 regimen) compared with doxorubicin alone in terms overall survival (OS), progression-free (PFS), safety patients advanced hepatocellular carcinoma (HCC). We present results this Chinese patients. Methods. In a multicenter, open-label, randomized, phase III (00471965), 371 (279 from People's Republic China) were randomized 1:1 to receive either or until disease progression,...
Sirtuin 5 (SIRT5) is a member of the NAD+‑dependent class III protein deacetylases. Although it known that SIRT5 deacetylates and activates urate oxidase in liver mitochondria mice, mechanism proliferation hepatocellular carcinoma (HCC) remains to be fully elucidated. The present study investigated expression functional significance HCC, examined relevant mechanism. was found upregulated HCC tissues cell lines, higher indicated poorer overall survival. Reverse transcription‑quantitative...
Indocyanine green fluorescence-guided laparoscopic hepatectomy (ICG-guided LH) is increasingly used for the treatment of hepatocellular carcinoma (HCC). However, whether ICG-guided LH can improve surgical outcomes remains unclear. This study aimed to investigate short-term and survival versus common (CLH) HCC.We conducted a retrospective analysis 104 158 CLH patients from 2014 2020 at our center. To avoid selection bias, 81 cases were analyzed after 1:1 propensity score matching (PSM). The...
Alternative splicing (AS) has a critical role in tumor progression and prognosis. Our study aimed to investigate pancreatic cancer-specific AS events using RNA-seq data, gaining systematic insights into potential prognostic predictors. We downloaded 10623 genes with 45313 from the Cancer Genome Atlas (TCGA) SpliceSeq database. Cox univariate analyses of overall survival suggested there was remarkable association between 6711 cancer patients (P<0.05). The area under curves receiver operator...
BACKGROUND:The right area and posterior of the liver are considered relatively unfavorable portions for laparoscopic hepatectomy (LH) due to limited gross inspection poor tactile feedback. Fusion indocyanine green fluorescence fusion imaging (ICGFI) may be a reliable real-time navigation tool LH. The aim present study was evaluate usefulness ICGFI non-anatomical in patients with hepatocellular carcinoma at area. MATERIAL AND METHODS:We conducted retrospective comparison surgical...
Background Accumulating evidence has revealed that CD8+ T cell exhaustion (Tex) results in worse immunotherapy outcomes. However, the molecular functions and mechanisms of action Tex chemoresistance needed to be elucidated. Methods The populations tumor-infiltrating cells (TILCD8Ts) chemoresistant chemosensitive groups GSE25066 dataset were calculated using CIBERSORT. Differentially expressed genes (DEGs) between TILCD8Ts other immune explored by integrating 16 datasets downloaded from gene...
BACKGROUND Postoperative pancreatic fistula remains a challenge after pancreaticoduodenectomy (PD). This study aimed to establish scoring system predict clinically relevant postoperative (CR-POPF) PD. MATERIAL AND METHODS The clinical records of 361 consecutive patients who underwent PD between 2009 and 2017 were reviewed retrospectively. Patients divided into group (225 patients) validation (136 patients). CR-POPF was defined classified based on the 2016 ISGPS definition classification...
Abstract Acute pancreatitis (AP) is a common acute abdominal condition of the digestive system. In recent years, treatment concepts, methods, and strategies for diagnosis AP have advanced, this has played an important role in promoting standardization improving quality patients. On basis previous guidelines expert consensus, guideline adopts evidence-based, problem-based expression; synthesizes clinical research data at home abroad most 5 years; forms 29 recommendations through...
Abstract The incidence of pancreatic cancer has been rising worldwide, and its clinical diagnosis treatment remain a great challenge. To present the update improvements in recent years, Chinese Pancreatic Association, Society Surgery, Medical Association revised Guidelines for Diagnosis Treatment Cancer China (2014) after reviewing evidence-based problem-oriented literature published during 2015–2021, mainly focusing on highlight issues regarding surgical cancer, conversion strategies...
Our study aimed to identify inflammatory biomarkers and develop a prediction model stratify high-risk patients for hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) recurrence after curative resection.A total of 583 eligible HBV-HCC with hepatectomy from Guangdong Provincial People's Hospital (GDPH) Sun Ya-sen University Cancer Centre (SYSUCC) were enrolled in our study. Cox proportional hazards regression was utilized evaluate potential risk factors disease-free survival...
To compare the characteristics of two single-incision methods, and conventional laparoscopy in cholecystectomy, demonstrate safety feasibility.Three hundred patients with gallstones or gallbladder polyps were admitted to clinical centers from January 2013 2014 randomized into three groups 100: three-device group, X-Cone group. The operative time, intraoperative blood loss, complications, postoperative pain, cosmetic score, length hospitalization, hospital costs compared, a follow-up duration...
Glycine-N-acyltransferase-like 1 (GLYATL1), which is involved in the detoxification of endogenous and exogenous acyl-CoA, promotes glutamine metabolism xenobiotic metabolism. Recent evidence suggests an association between GLYATL1 tumors. However, there are few comprehensive analyses cancers. We evaluated expression prognostic value explored mechanism underlying cancers.GLYATL1 mRNA across cancers was investigated Oncomine database confirmed UALCAN Gene Expression Profiling Interactive...
Friend leukemia virus integration 1 (Fli‑1) is a newly identified ETS protein, and has critical roles in many malignancies. However, the physiological characters potential mechanisms of Fli‑1 hepatocellular carcinoma (HCC) progression remains unclear. In present study, was highly expressed HCC samples tumor cell lines. knockdown with small interfering (si)RNAs significantly reduced colony formation metastasis capacity lines vitro. Subsequent investigation that functioned as an oncogene...