A5101896365- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Renal cell carcinoma treatment
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune cells in cancer
- Bladder and Urothelial Cancer Treatments
- Mycobacterium research and diagnosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Gallbladder and Bile Duct Disorders
- Endometriosis Research and Treatment
- Single-cell and spatial transcriptomics
- Fungal Infections and Studies
- Esophageal and GI Pathology
- Bioinformatics and Genomic Networks
- Infectious Diseases and Mycology
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Connective Tissue Growth Factor Research
Peking University
2016-2025
Peking University Third Hospital
2016-2025
Fourth Hospital of Changsha
2024
Hangzhou City University
2024
Huazhong University of Science and Technology
2023
Wuhan Children's Hospital
2023
Johns Hopkins Medicine
2019
Johns Hopkins University
2019
Objective: The purpose of this study is to determine preoperative factors that are predictive malignancy in patients undergoing pancreatic resection for intraductal papillary mucinous neoplasms (IPMN). Summary Background Data: IPMN the pancreas may be precursor lesions cancer (PC) and represent a target early diagnosis or prevention. While there has been much effort define risk malignant pathology, guidelines ever-changing controversy remains surrounding which would benefit most from...
Duodenal adenocarcinoma (DA) has a high recurrence rate, making the prediction of after surgery critically important. Our objective is to develop machine learning-based model predict postoperative DA. We conducted multicenter, retrospective cohort study in China. 1830 patients with DA who underwent radical between 2012 and 2023 were included. Wrapper methods used select optimal predictors by ten learning learners. Subsequently, these learners utilized for development. The model's performance...
The incidence of small (≤2 cm), non-functioning pancreatic neuroendocrine tumors (NF-pNETs) increased in the last decades. Before making appropriate strategy for patients with NF-pNETs ≤2 cm, pathological confirmation is vital. Incidentally diagnosed, sporadic may bring aggressive behavior and poor prognosis, such as extrapancreatic extension, lymph nodal metastasis, distant metastasis recurrence, even causing disease-related death. Understanding formulating an small, have been controversial...
Recently, increasing evidence has indicated that the presence of tumor infiltrating immune cells shown predictive significance for many solid tumors. Present study was performed to evaluate value stromal tumor-infiltrating lymphocytes (TILs) liver metastasis and overall survival in PDAC (pancreatic ductal adenocarcinoma) patients after complete resection explore potential role PDAC. A total 155 resectable with were enrolled our study. Stromal TIL density investigated hematoxylin...
Background Frailty is a common condition among patients with liver cirrhosis. Nonetheless, its role in predicting transplant-free survival (TFS) remains unclear. Aim This systematic review and meta-analysis were conducted to elucidate the relationship between frailty TFS Methods Cohort studies addressing objective of this extracted from PubMed, Embase, Web Science databases. Between-study heterogeneity was assessed Cochrane Q test, I^2 statistic estimated. Random-effect models, considering...
Pancreatic cancer is a lethal disease with very poor prognosis. This study investigates survival of patients diagnosed metastatic pancreatic (mPC) based on local treatment the primary tumor.Patients stage IV mPC between 2004 and 2013 were identified from Surveillance, Epidemiology End Results (SEER) database. Cancer-specific (CSS) overall (OS) examined. CSS OS examined by using Kaplan-Meier method log-rank test. Multivariable analyses conducted Cox proportional hazard model.A total 28918...
This study investigates survival of patients diagnosed with pancreatic neuroendocrine tumor liver metastases based on local treatment the primary tumor. Patients stage IV PNET between 2010 and 2014 were identified from Surveillance Epidemiology End Results database. Cancer-Specific Survival Overall examined. A total 191 included in this analysis. There 47 (24.6%) who received surgical resection 144 (75.4%) did not. N1 was more likely to be treated resection. The results showed that...
The aim of this study was to investigate the role tumor-associated neutrophils (TANs) in metastasis pancreatic ductal adenocarcinoma (PDAC), explore regulation TANs, and determine mechanisms governing PDAC. correlation between patient's clinical pathological data first evaluated. Then, effects on invasion PDAC were analyzed using a combination conditioned media, direct indirect coculture human peripheral blood neutrophils, cell lines (Panc-1, MiaPaCa-2 AsPC-1). cytokines secreted by detected...
Background: Differentiated thyroid cancer (DTC) is increasingly common in women of reproductive age. However, whether pregnancy increases the risk DTC progression/recurrence after treatment remains controversial. The study aimed to assess association with progression patients previously treated for DTC. Methods: This was a retrospective cohort following 123 pregnant and 1376 nonpregnant at Peking University Third Hospital initial between January 2012 December 2022. To control effect...
Abstract Context and Objective Differentiated thyroid cancer (DTC) is very common in women of reproductive age. However, it remains unclear whether pregnancy associated with DTC progression before surgical treatment. Methods This retrospective cohort study, conducted at the Peking University Third Hospital Beijing, China between January 2012 December 2022, included 311 eligible aged 20 to 45 years. To control for potential confounders, we first used propensity score matching (PSM) match...
Abstract Objective: The aim of this study is to investigate the current status pancreatic cancer patients undoing surgical treatment in China and find ways improve survival these future. Methods: This a national, multicenter, cross-sectional China. Information regarding undergoing from 34 high-volume tertiary IIIA level hospitals was collected analyzed March 1, 2016 February 28, 2017. Results: In total, 2200 were enrolled 16 provinces across male-to-female ratio 1.5. More than 80% between 50...
Abstract Tumor microenvironment (TME) exerts key roles in pancreatic ductal adenocarcinoma (PDAC) development. However, the factors regulating cross-talk between PDAC cells and TME are largely unknown. In present study, we identified a long noncoding RNA (lncRNA) KLHDC7B divergent transcript (KLHDC7B-DT), which was up-regulated correlated with poor survival of patients. Functional assays demonstrated that KLHDC7B-DT enhanced cell proliferation, migration, invasion. Mechanistically, found to...
The incidence of duodenal adenocarcinoma is increasing, with limited studies on this disease published. This multicenter retrospective study aimed to analyze the clinicopathologic features and identify prognostic factors for postoperative survival.
Abstract The incidence of pancreatic cancer has been rising worldwide, and its clinical diagnosis treatment remain a great challenge. To present the update improvements in recent years, Chinese Pancreatic Association, Society Surgery, Medical Association revised Guidelines for Diagnosis Treatment Cancer China (2014) after reviewing evidence-based problem-oriented literature published during 2015–2021, mainly focusing on highlight issues regarding surgical cancer, conversion strategies...
Pancreatic neuroendocrine neoplasms (pNENs) are highly heterogeneous, and the management of pNENs patients can be intractable. To address this challenge, an expert committee was established on behalf Group Surgery, Chinese Society Medical Association, which consisted surgical oncologists, gastroenterologists, medical endocrinologists, radiologists, pathologists, nuclear medicine specialists. By reviewing important issues regarding diagnosis treatment pNENs, concluded evidence-based...
Background Bladder cancer has become an increasingly intractable health problem worldwide. Long-term drinking water pollution is known to promote its occurrence. This study aimed analyze the research status, hot spots, and future trends of bladder through extensive bibliometric examination provide reference data for better prevention management cancer. Methods The Scopus database developed by Elsevier was browsed articles that met predefined criteria using search terms related Included were...
Objective: The aim of this study is to investigate the current status diagnosis and treatment patients with pancreatic neuroendocrine neoplasms (pNENs) undergoing surgery in China. Methods: This a multicenter cross-sectional performed Data from pNENs at 33 high-volume medical centers, where number pancreatectomies exceeds 20 cases per year, were collected analyzed between March 1, 2016 February 28, 2017. Results: In total, 392 enrolled. male female ratio was 1.4. majority aged 40 70 years....
Surgical resection is the only potentially curative treatment for pancreatic ductal adenocarcinoma (PDAC). However, most of patients lose chance surgery due to unresectable disease at time diagnosis. Despite improvement radiological imaging, a portion intended radical were proven be surgical exploration occult metastasis.Patients who aimed undergo pancreatectomy PDAC from 2010 2019 reviewed retrospectively. All included underwent diagnostic laparoscopic exploration. Patients divided into two...
Background Pancreatic neuroendocrine tumors (pNETs) are a type of with the characteristics easy metastasis and recurrence. Till date, risk factors affecting prognosis still in debate. In this study, several will be discussed combined our cases experience. Methods Thirty-three patients diagnosed as pNETs were enrolled clinical features, blood tests, pathological surgical treatment, follow-up data these collected analyzed. Results operation time G3 was longer than G1/G2 ( P =0.017). The...
Abstract Pancreatic neuroendocrine neoplasms (pNENs) are highly heterogeneous, and the management of pNENs patients can be intractable. To address this challenge, an expert committee was established on behalf Chinese Surgery Association, which consisted surgical oncologists, gastroenterologists, medical endocrinologists, radiologists, pathologists, nuclear medicine specialists. By reviewing important issues regarding diagnosis treatment pNENs, concluded evidence-based statements...
Several treatment guidelines for sporadic, nonmetastatic nonfunctioning neuroendocrine tumors of the pancreas (NF-pNETs) have recommended resection, however, ≤ 2 cm do not necessarily need surgery. This study aims to establish a surgical plan NF-pNETs cm. From 2000 2017, 483 patients who underwent resection in 18 institutions from Korea and China were enrolled their medical records reviewed. The median age was 56 (range 16-80) years. 10-year overall survival rate (10Y-OS) recurrence-free...
Objective To establish a nomogram for predicting the distant metastasis risk of pancreatic neuroendocrine tumors (pNETs) in elderly patients. Methods We extracted data patients with diagnosis pNETs at age ≥65 years old between 1973 and 2015 from Surveillance, Epidemiology, End Results (SEER) database. All eligible were divided randomly into training cohort validation cohort. Uni- multivariate logistic regression analyses performed on to identify independent factors metastasis. A was...