A5101575011- Gallbladder and Bile Duct Disorders
- Psoriasis: Treatment and Pathogenesis
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Asthma and respiratory diseases
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Dermatology and Skin Diseases
- Neuroblastoma Research and Treatments
- Gastric Cancer Management and Outcomes
- Hepatitis C virus research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Wnt/β-catenin signaling in development and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sepsis Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Proteoglycans and glycosaminoglycans research
- Phagocytosis and Immune Regulation
- Cell Image Analysis Techniques
Huzhou Central Hospital
2013-2025
Huzhou University
2021-2025
East China University of Science and Technology
2025
Zhejiang Chinese Medical University
2022-2024
Zhejiang University
2012-2024
Zhejiang Lab
2024
First Affiliated Hospital of Anhui Medical University
2020-2023
Anhui Medical University
2020-2023
Shanghai Skin Disease Hospital
2022
Tongji University
2022
Background Pancreatic cancer (PC) is a common malignancy of the digestive system and characterized by poor prognosis early metastasis. Tumor immune escape plays an important role in PC progression. Programmed death 1 (PD1) blockade therapy promising treatment for patients with PC, but yet to achieve significant clinical effects so far. Interferon gamma (IFN-γ) soluble dimeric cytokine that closely associated tumor surveillance cytotoxicity. IFN-γ suppresses variety tumor-derived cytokines...
A large percentage of patients undergoing esophagogastroduodenoscopy (EGD) screening do not have esophageal varices (EV) or only small EV. We evaluated a large, international, multicenter cohort to develop novel score, termed FIB-4plus, by combining the fibrosis-4 (FIB-4) liver stiffness measurement (LSM), and spleen (SSM) identify high-risk EV (HRV) in compensated cirrhosis. This international study involved with cirrhosis from 17 Chinese hospitals one Croatian institution (NCT04546360)....
Liver transplantation is currently the sole definitive treatment option for end-stage liver failure. However, a significant shortage of donors prevails due to high clinical demands. Recently, human organoids have shown potential in regenerative medicine diseases. Nevertheless, current static cultures grown well-plates heavily rely on extracellular matrix hydrogels (Matrigel), thereby limiting both scalability and quantity organoid culture. In this study, we present groundbreaking culture...
Aim . To evaluate the possible association between vitamin D receptor (VDR), single-nucleotide polymorphisms (SNPs), and hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. Method 968 HBV infection were enrolled, of which 436 diagnosed HCC patients, 532 non-HCC patients. The clinicopathological characteristics evaluated. genotypes VDR gene at FokI, BsmI, ApaI, TaqI determined. Results genotype frequencies FokI C>T polymorphism significantly different...
The incidence of small (≤2 cm), non-functioning pancreatic neuroendocrine tumors (NF-pNETs) increased in the last decades. Before making appropriate strategy for patients with NF-pNETs ≤2 cm, pathological confirmation is vital. Incidentally diagnosed, sporadic may bring aggressive behavior and poor prognosis, such as extrapancreatic extension, lymph nodal metastasis, distant metastasis recurrence, even causing disease-related death. Understanding formulating an small, have been controversial...
Pancreatic neuroendocrine neoplasms (p-NENs) are slowly growing tumors with frequent liver metastasis. There is a variety of approaches to treat non-functional p-NENs synchronous metastasis (LM) which complicates the determination optimal treatment. Based on updated literature review, we discussed treatment strategy determinants for p-NEN LM. According resectability primary tumor, WHO 2010 grade classification and radiological type metastasis, CSNET group reached agreements number issues,...
Pancreatic cancer is one of the most lethal cancers and its prognosis extremely poor. Clarification molecular mechanisms identification prognostic biomarkers are urgently needed. Though we previously found that LGMN was involved in pancreatic carcinoma progression, upstream regulation remains unknown. We used reliable software to search for potential transcription factors may be related with transcription, ELK1 could a new regulator binded directly promoter. Moreover, knocking down reduced...
Abstract Background Cholelithiasis is one of the most common disorders hepatobiliary system. Gut bacteria may be involved in process gallstone formation and are, therefore considered as potential targets for cholelithiasis prediction. Objective To reveal correlation between gut bacteria. Methods Stool samples were collected from 100 250 healthy individuals Huzhou Central Hospital; The 16S rRNA stool was sequenced using third-generation Pacbio sequencing platform; Mothur v.1.21.1 used to...
Background Recurrence of hepatitis B-related hepatocellular carcinoma (HCC) after curative resection is the leading factor influencing prognosis disease. Therefore, further improvement long-term survival may depend on prevention and treatment recurrent tumor. The aim this research was to investigate role antiviral therapy postoperative transcatheter arterial chemoembolization (TACE) in HCC recurrence. Methods One hundred twenty patients who underwent between January 2005 June 2008 at our...
Abstract Background There are few widely accepted and operationally feasible models for predicting the mortality risk of patients in surgical intensive care unit (SICU). Although serum anion gap (AG) is known to be correlated with severe metabolic acidosis, no investigations have been reported about association between AG level outcome during hospitalization SICU. This study aimed explore predictive power 90-day all-cause Methods Data eligible SICU from 2008 2019 was obtained Medical...
Abstract Background Microsatellite instability (MSI) caused by DNA mismatch repair (MMR) deficiency is of great significance in the occurrence, diagnosis and treatment colorectal cancer (CRC). Aim This study aimed to analyze relationship between status clinical characteristics CRC. Methods The histopathological results 2029 patients who suffered from CRC underwent surgery at two centers 2018 2020 were determined. After screening importance through machine learning algorithms, divided into...
Patients with previous gastrectomy have an increased incidence of gallstones and gallbladder morbidity requiring surgery. We investigated the possible risk factors that contribute to severe disease in patients role laparoscopic cholecystectomy (LC) treatment these patients.In this retrospective study, we reviewed a database who underwent LC our hospital during period January 1, 2010, through May 2015.The average operation time was longer (P < .05), but times long interval (>5 years) between...
Introduction. The modification of lysine crotonylation (Kcr) is another biological function histone in addition to acetylation (Kac), which may play a specific regulatory role diseases. Objectives. This study compared the expression levels Kcr and proteome between patients with chronic obstructive pulmonary disease (COPD) combined type II respiratory failure (RF) relationship Kcr, proteome, COPD. Methods. We tested COPD RF normal control (NC) using croton acylation enrichment technology...
Gender difference is prevalent in clinical feature, disease severity for noncommunicable diseases (NCD), but studies on gender disparity and NCD comorbidity among psoriasis patients are limited. This cross-sectional study explores differences lifestyle behavior patients.Psoriasis were recruited through cluster survey method two hospitals, questionnaire interviews applied to collect the demographic habits, feature patients.A total of 2102 included 1332 males (63.4%), 70% over 35 years old...
Transplantation is currently the best treatment for patients with end‑stage renal disease. However, acute rejection (AR) major source of failure in transplantation. The current practice diagnosis AR involves biopsy, but it invasive, time‑consuming, costly and inconvenient. Sensitive less invasive detection episodes transplant essential to preserve allograft function. present study applied isobaric tags relative absolute quantitation (iTRAQ) mass spectrometry analyze serum protein expression...
Background. Genetic studies identified a dozen of frequently mutated genes in gastric cancer, such as cadherin 1 (CDH1) and A-kinase anchoring protein 9 (AKAP9). Of note, genetic alterations including depletion amplification frameshift mutations AKAP9 have been observed 10–15% cancer patients. However, it is unknown the expression role cancer. This study aimed to characterize function Methods. Using qRT-PCR, we analyzed mRNA levels patient samples. We investigated by performing cell...
Background Postoperative recurrence of hepatocellular carcinoma (HCC) is associated with low survival rates. While HCC treatment options have expanded substantially, they are accompanied by several challenges. This study assessed the outcomes repeated hepatectomy (RH) for postoperative intrahepatic among patients undergoing initial (IH) as well independent risk factors (RH). Methods Clinical data from 84 both IH and RH 66 recurrent who had received radiofrequency ablation (RFA) July 2011 to...
Peptide-functionalized hydrogel is one of commonly used biomaterials to introduce hydrogel-induced vessel regeneration. Despite many reports about the discoveries high-active peptides (or ligands) for regeneration, study on conjugating methods functionalization with limited. Here, we compared vasculogenic efficacy peptide-functionalized hydrogels prepared by two methods, 1-ethyl-3-(3-dimethylamino propyl) carbodiimide (EDC) and Click through cell models, organ-on-chips animal RNA sequencing...
BACKGROUND:The currently available chemotherapeutic regimens do not use a specifically designed drug delivery system. The objective of this study was to compare outcome measures, adverse effects, and cost FOLFOX4 FOLFIRINOX treatments in rectal cancer patients. MATERIAL AND METHODS:We enrolled patients who, after surgery, did undergo chemotherapy or radiotherapy (Control group); were administered 200 mg/m² folinic acid, 400 fluorouracil, 85 oxaliplatin (FFO 180 irinotecan, mg/m2 (FFIO...