A5039256728- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Electrocatalysts for Energy Conversion
- Advanced Nanomaterials in Catalysis
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Nanoparticle-Based Drug Delivery
- RNA and protein synthesis mechanisms
- Electrochemical Analysis and Applications
- Human Mobility and Location-Based Analysis
- Biosensors and Analytical Detection
- Traffic Prediction and Management Techniques
- Electrochemical sensors and biosensors
- Immunotherapy and Immune Responses
- Advanced Photocatalysis Techniques
- Environmental remediation with nanomaterials
- Supercapacitor Materials and Fabrication
- Cancer, Hypoxia, and Metabolism
- Nanocluster Synthesis and Applications
- Advanced battery technologies research
- Advanced Biosensing Techniques and Applications
- Ammonia Synthesis and Nitrogen Reduction
- Nanomaterials for catalytic reactions
- Advancements in Battery Materials
Nanjing University
2018-2025
Southwest University of Science and Technology
2024-2025
Zhejiang Shuren University
2024-2025
Zhejiang University of Technology
2019-2024
Guangxi University
2021-2024
Hainan University
2021-2024
Zhejiang Chinese Medical University
2022-2024
Hunan University
2017-2024
Southwest Minzu University
2024
George Mason University
2022-2024
Abstract Hypoxia, as characterized by the low local oxygen, confers on cancer cells resistance to oxygen‐consuming photodynamic therapy (PDT). The limited success reached current approaches harnessing reoxygenation enhance PDT outcome promotes reconsideration of design therapeutic approach. In this study, a multistage delivery system capable reversing hypoxia is demonstrated. Unlike previous strategies that only expect affect peripheral tumor tissue, size‐shrinkable allows those deeply...
Abstract Electrocatalytic glycerol oxidation reaction (GOR) stands out as an economical and prospective technology to replace oxygen evolution for co‐producing high‐valued chemicals hydrogen (H 2 ). Regulating the adsorption of (GLY) hydroxyl (OH) species is great significance improving GOR performance. Herein, a hierarchical p–n heterojunction by combining Co‐metal organic framework (MOF) nanosheets with CuO nanorod arrays (CuO@Co‐MOF) developed realize optimization on GOR. Specifically,...
RNA viruses represent a major global health threat, and the visualization of their genome in infected cells is essential for virological research clinical diagnosis. Due to lack chemical toolkits live-cell imaging viral genomes, especially native genomes without labeling genetic modification, studies on virus infection at single-live-cell level are challenging. Herein, taking hepatitis C (HCV) as representative virus, we propose that innate noncanonical G-quadruplex (G4) structure can serve...
Abstract The comprehensive understanding of the mechanisms underlying interaction cells with their membrane microenvironment is great value for fundamental biological research; however, tracking biomolecules on cell surfaces high temporal and spatial resolution remains a challenge. Herein, modular strategy presented construction surface DNA‐based sensors by engineering DNA motifs synthetic cofactors. In this strategy, stimuli‐reactive organic molecule employed as cofactor motif,...
Abstract Metal‐organic frameworks (MOFs) have attracted increasing attention as a promising electrode material for the oxygen evolution reaction (OER). Comprehending catalytic mechanisms in OER process is of key relevance design efficient catalysts. In this study, two types Co based MOF with different organic ligands (ZIF‐67 and CoBDC; BDC=1,4‐benzenedicarboxylate) are synthesized electrocatalysts their electrochemical behavior studied alkaline solution. Physical characterization indicates...
Neutral nanomaterials functionalized with PEG or similar molecules have been popularly employed as nanomedicines. Compared to positive counterparts that are capable of harnessing the well-known proton sponge effect facilitate their escape from lysosomes, it is yet unclear how neutral substances got entry into cytosol. In this study, by taking PEGylated, Au nanospheres an example, we systematically investigated time-dependent translocation postuptake. Specifically, harnessed dissipative...
Red fluorescent proteins (RFPs) have emerged as valuable biological markers for biomolecule imaging in living systems. Developing artificial fluorogenic systems that mimic RFPs remains an unmet challenge. Here, we describe the design and synthesis of six new chromophores analogous to RFPs. We demonstrate, first time, encapsulating RFP chromophore analogues canonical DNA G-quadruplexes (G4) can activate bright fluorescence spanning red far-red spectral regions (Em = 583-668 nm) nearly match...
Abstract Treatment of liver metastasis experiences slow progress owing to the severe side effects. In this study, we demonstrate a strategy capable eliminating metastatic cancer cells in selective manner. Nucleus-targeting W 18 O 49 nanoparticles (WONPs) are conjugated mitochondria-selective mesoporous silica (MSNs) containing photosensitizer (Ce6) through Cathepsin B-cleavable peptide. hepatocytes, upon laser irradiation, generated singlet oxygen species consumed by WONPs, turn leading loss...
GFP-like fluorescent proteins and their molecular mimics have revolutionized bioimaging research, but emissions are largely limited in the visible to far-red region, hampering vivo applications intact animals. Herein, we structurally modulate chromophores using a donor–acceptor–acceptor (D–A–A′) configuration discover set of novel fluorogenic derivatives with infrared-shifted spectra. These can be fluorescently elicited by specific interaction G-quadruplex (G4), unique noncanonical nucleic...
The electrocatalytic performance of 5-hydroxymethylfurfural (HMF) oxidation was improved by NiCo-based bimetallic-sites construction and S coordination species tuning.
Copper ions play vital roles in regulating life processes and being closely involved several diseases such as cancer. Although detection methods based on fluorescent sensors or other strategies have been developed, it still remains a challenge to simultaneously realize the convenience, specificity, accuracy intracellular copper ion analysis. Herein, we propose an aptamer-functionalized DNA sensor (AFDS) for accurate specific of Cu(II) both vitro cells by engineering linkage two aptamers,...
Abstract The hyperactive energy metabolism mostly contributes the tumor cells growth and proliferation. Herein, intelligent nanoparticles (P‐B‐D NPs) obtained by loading BAY‐876 doxorubicin (Dox)‐Duplex into composed of disulfide bond (SS) containing polymer are reported, which provide an efficient resistance to conquer malignant tumor. In response reducing microenvironment tissue, SS can be disintegrated intracellular glutathione block synthesis lipid repair enzyme‐glutathione peroxidase...
Abstract Although much progress has been made by multifunctional nanoplatforms in the treatment of cancer, several defects existing nanoplatforms, such as tedious preparation, poor biocompatibility, and failure to activate immune system, have limited their clinical applications. Herein, a versatile nanosystem folic acid‐modified metal‐phenolic networks (MPNs) loaded with GOx CHA (F‐MGC) is fabricated easy self‐assembly MPNs, during which glucose oxidase (GOx) chlorogenic acid (CHA) are...
The acidity and high GSH level in the tumor microenvironment (TME) greatly limit antitumor activity of nanozymes. Thus, enhancing nanozymes' is fundamentally challenging therapy. Although combination photothermal therapy (PTT) nanozymes can enhance catalytic activity, cancer cells will overexpress heat shock proteins (HSPs) at temperature, aggravating resistance cells, which turn compromises outcome chemodynamic Herein, we propose an iron-doped metal-organic framework nanozyme...
Lithium is an important alkalinous metal with a wide range of usage and high economic value. With the transformation global energy structure rapid development new industry, demand for lithium increasing. Therefore, it great strategic significance value to find ways obtain resources. The total amount secondary resources abundant, but current research mainly focuses on extraction from waste lithium-ion batteries (LIBs), rather than generated during LIB production. in this study, sludge...
Liver transplantation is currently the sole definitive treatment option for end-stage liver failure. However, a significant shortage of donors prevails due to high clinical demands. Recently, human organoids have shown potential in regenerative medicine diseases. Nevertheless, current static cultures grown well-plates heavily rely on extracellular matrix hydrogels (Matrigel), thereby limiting both scalability and quantity organoid culture. In this study, we present groundbreaking culture...