Lu Xu

ORCID: 0000-0001-8314-1842
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About
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Research Areas
  • Insect-Plant Interactions and Control
  • Insect Resistance and Genetics
  • Insect and Pesticide Research
  • Neurobiology and Insect Physiology Research
  • Insect Pest Control Strategies
  • Animal Virus Infections Studies
  • Insect and Arachnid Ecology and Behavior
  • Plant Virus Research Studies
  • Environmental Toxicology and Ecotoxicology
  • Advanced biosensing and bioanalysis techniques
  • Viral gastroenteritis research and epidemiology
  • Viral Infections and Immunology Research
  • Molecular Sensors and Ion Detection
  • Animal Disease Management and Epidemiology
  • Viral Infections and Vectors
  • DNA and Nucleic Acid Chemistry
  • Genetic Mapping and Diversity in Plants and Animals
  • Plant-Microbe Interactions and Immunity
  • CRISPR and Genetic Engineering
  • Mycorrhizal Fungi and Plant Interactions
  • Cancer-related molecular mechanisms research
  • Genetic and phenotypic traits in livestock
  • Plant Parasitism and Resistance
  • Plant Molecular Biology Research
  • Supramolecular Self-Assembly in Materials

Southwest University
2024

China Medical University
2024

Jiangsu Academy of Agricultural Sciences
2016-2024

Institute of Plant Protection
2016-2024

China Pharmaceutical University
2024

Hebei Agricultural University
2024

Tianjin University of Science and Technology
2024

First Hospital of China Medical University
2024

State Key Laboratory of Chemobiosensing and Chemometrics
2019-2022

Huazhong Agricultural University
2019-2022

Abstract The comprehensive understanding of the mechanisms underlying interaction cells with their membrane microenvironment is great value for fundamental biological research; however, tracking biomolecules on cell surfaces high temporal and spatial resolution remains a challenge. Herein, modular strategy presented construction surface DNA‐based sensors by engineering DNA motifs synthetic cofactors. In this strategy, stimuli‐reactive organic molecule employed as cofactor motif,...

10.1002/anie.201901320 article EN Angewandte Chemie International Edition 2019-03-07

The rice striped stem borer (SSB), Chilo suppressalis (Walker), is one of the most economically important and destructive pests in China. To date, efficiency conventional insecticides has decreased greatly because development high resistance. Since introduction chlorantraniliprole 2008, SSB presented resistance issues.In this study, laboratory resistant strains R1 R2 [resistance ratio (RR) 38.8 110.4, respectively] were established a field population HR (RR 249.6) was collected. Synergist...

10.1002/ps.4824 article EN Pest Management Science 2017-12-13

The rice striped stem borer (SSB), Chilo suppressalis (Walker), which is one of the most economically important phytophagous pests, has developed resistance to multiple insecticides. SSB against chlorantraniliprole been investigated in detail. However, mechanism its metabolic rarely studied.A field population from Wuhu City, China was used establish resistant and susceptible strains (WHR WHS) by laboratory continuous selection. Enzyme activities data suggested potential involvement...

10.1002/ps.5171 article EN Pest Management Science 2018-08-13

The white-backed planthopper (WBPH) Sogatella furcifera, the brown (BPH) Nilaparvata lugens, and small (SBPH) Laodelphax striatellus (Hemiptera: Delphacidae) are rice pests that damage plants by sap-sucking transmitting viruses. Host-seeking behavior involves chemosensory receptor genes include odorant receptors (ORs), ionotropic (IRs) gustatory (GRs).

10.1002/ps.4912 article EN Pest Management Science 2018-03-15

Uridine diphosphate glycosyltransferases (UGTs) are multifunctional detoxification enzymes, which involved in metabolizing various chemicals and contribute to the development of insecticide resistance. However, possible roles UGTs chlorantraniliprole resistance Chilo suppressalis have rarely been studied detail. Based on genome data, 24 UGT genes C. belonging 11 families were identified, designated by nomenclature committee. Synergism assay data suggested that potentially...

10.3390/ijms20051064 article EN International Journal of Molecular Sciences 2019-03-01

G-quadruplex (G4) is a noncanonical nucleic acid secondary structure that has implications for various physiological and pathological processes thus essential to exploring new approaches G4 detection in live cells. However, the deficiency of molecular imaging tools makes it challenging visualize ex vivo tissue samples. In this study, we established probe design strategy presented red fluorescent benzothiazole derivative, ThT-NA, detect image structures living cells By enhancing...

10.1021/acs.analchem.2c02049 article EN Analytical Chemistry 2022-07-01

Background: Liquid-Liquid Phase Separation (LLPS) is a process involved in the formation of established organelles and various condensates that lack membranes; however, relationship between LLPS Ulcerative Colitis (UC) remains unclear. Aims: This study aimed to comprehensively clarify correlation ulcerative colitis liquid-liquid phase separation (LLPS). Objectives: In this study, bioinformatics analyses public databases were applied screen validate key genes associated with UC. Furthermore,...

10.2174/0118715303355042241208171133 article EN Endocrine Metabolic & Immune Disorders - Drug Targets 2025-01-08

Laboratory selection is often employed in resistance mechanism studies because field-derived populations commonly do not have high enough for such studies. In the present study, a field-collected Laodelphax striatellus population from eastern China was laboratory selected chlorpyrifos and susceptibility, developed strains, along with field population, were studied cross-resistance mechanisms at biochemical molecular levels.A 158.58-fold chlorpyrifos-resistant strain (JH-chl)...

10.1002/ps.3657 article EN Pest Management Science 2013-10-12

The anthranilic diamide insecticide chlorantraniliprole has been extensively applied to control Lepidoptera pests. However, its overuse leads the development of resistance and accumulation residue in environment. Four P450s (CYP6CV5, CYP9A68, CYP321F3, CYP324A12) were first found be constitutively overexpressed an SSB CAP-resistant strain. It is imperative further elucidate molecular mechanisms underlying P450s-mediated CAP for mitigating environmental contamination. Here, we heterologously...

10.1016/j.scitotenv.2023.169229 article EN cc-by-nc-nd The Science of The Total Environment 2023-12-08

BackgroundThe small brown planthopper (SBPH), Laodelphax striatellus (Fallén), is one of the major rice pests in Asia and has developed resistance to multiple classes insecticides. Understanding mechanisms essential management this pest. Biochemical molecular assays were performed study systematically characterize deltamethrin with laboratory-selected resistant susceptible strains SBPH. Methodology/Principal FindingsDeltamethrin SBPH (JH-del) derived from a field population by continuously...

10.1371/journal.pone.0079443 article EN cc-by PLoS ONE 2013-11-04

The anthranilic diamide insecticide chlorantraniliprole is highly effective against Lepidoptera pests, but the underlying mechanisms of toxic effects exposures for adapting to chemical environment are poorly known in fall armyworm (FAW), Spodoptera frugiperda (J.E.Smith). FAW being one most pests maize Latin America, suddenly appeared China 2019 and spread rapidly. In this study, using bioassay transcriptomic biochemical analyses, we comprehensively investigated gene expression changes third...

10.1016/j.ecoenv.2021.113145 article EN cc-by Ecotoxicology and Environmental Safety 2021-12-31

This study investigated the efficacy of three spray adjuvants (Coerce, Wetcit, and Silwet408) in enhancing dinotefuran permeation rice leaves. Different concentrations these were tested using an external standard method. The leaf surface was analyzed by van Oss–Chaudhury–Good method to establish a link between free energy (SFE) permeation. All effectively increased leaves, with highest 8.496 mg/kg achieved Wetcit at 1000 mg/L. SFE determined be 29.28 mJ/m2. A notable correlation observed...

10.3390/agronomy14030516 article EN cc-by Agronomy 2024-03-02

Chemosensory systems play an important role in insect behavior, and some key associated genes have potential as novel targets for pest control. Cacopsyllachinensis is oligophagous has become one of the main pests pear trees, but little known about molecular-level means by which it locates its hosts. In this study, we assembled head transcriptome C.chinensis using Illumina sequencing, 63,052 Unigenes were identified. A total 36 candidate chemosensory identified, including five different...

10.3390/insects10060175 article EN cc-by Insects 2019-06-17
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