A5086260335- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Molecular Sensors and Ion Detection
- DNA and Nucleic Acid Chemistry
- Nanoplatforms for cancer theranostics
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Acoustic Wave Resonator Technologies
- Advanced Biosensing Techniques and Applications
- Nanoparticles: synthesis and applications
- Luminescence and Fluorescent Materials
- Advanced Drug Delivery Systems
- Click Chemistry and Applications
- Probiotics and Fermented Foods
- Supramolecular Self-Assembly in Materials
- RNA and protein synthesis mechanisms
- Nanocluster Synthesis and Applications
- Animal Virus Infections Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Animal Nutrition and Physiology
- Cholinesterase and Neurodegenerative Diseases
- Photochemistry and Electron Transfer Studies
- Microencapsulation and Drying Processes
- Chemical Synthesis and Analysis
- Carbon and Quantum Dots Applications
Hunan Agricultural University
2019-2025
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
State Key Laboratory of Chemobiosensing and Chemometrics
2017-2019
Hunan University
2017-2019
RNA viruses represent a major global health threat, and the visualization of their genome in infected cells is essential for virological research clinical diagnosis. Due to lack chemical toolkits live-cell imaging viral genomes, especially native genomes without labeling genetic modification, studies on virus infection at single-live-cell level are challenging. Herein, taking hepatitis C (HCV) as representative virus, we propose that innate noncanonical G-quadruplex (G4) structure can serve...
Abstract The comprehensive understanding of the mechanisms underlying interaction cells with their membrane microenvironment is great value for fundamental biological research; however, tracking biomolecules on cell surfaces high temporal and spatial resolution remains a challenge. Herein, modular strategy presented construction surface DNA‐based sensors by engineering DNA motifs synthetic cofactors. In this strategy, stimuli‐reactive organic molecule employed as cofactor motif,...
Red fluorescent proteins (RFPs) have emerged as valuable biological markers for biomolecule imaging in living systems. Developing artificial fluorogenic systems that mimic RFPs remains an unmet challenge. Here, we describe the design and synthesis of six new chromophores analogous to RFPs. We demonstrate, first time, encapsulating RFP chromophore analogues canonical DNA G-quadruplexes (G4) can activate bright fluorescence spanning red far-red spectral regions (Em = 583-668 nm) nearly match...
By revealing the intrinsic link between inherent advantages of nanocellulose and hydrogels, we highlight applications hydrogels in medical treatment, electricity, sensor, environmental governance, food, agriculture.
The occurrence of inflammatory bowel disease (IBD) is relevant to impaired intestinal mucosal barrier and disordered gut microbiota, subsequently leading excessive production reactive oxygen species (ROS) elevated levels factors. Traditional therapies focus on inhibiting inflammation, but the vast majority involve non-targeted systemic administration, whose long-term use may result in potential side effects. Oral microbial therapy has exhibited great application prospects currently IBD...
Soil salinity seriously hinders the sustainable development of green agriculture. The emergence engineered nanomaterials has revolutionized agricultural research, providing a new means to overcome limitations associated with current abiotic stress management and achieve highly productive Herein, we synthesized brand-new nanomaterial (Cs–Se NMs) through Schiff base reaction oxidized chitosan selenocystamine hydrochloride alleviate salt in plants. After addition 300 mg/L Cs–Se NMs, activity...
Rational regulation of reactive oxygen species (ROS) plays a vital importance in maintaining homeostasis living biological systems. For ROS-related pathologies, chemotherapy technology derived from metal nanomaterials currently occupies pivotal position. However, they suffer inherent issues such as complicated synthesis, batch-to-batch variability, high cost, and potential toxicity caused by elements. Here, we reported for the first time that dual-action...
A two-photon fluorescent probe has been adopted for bisulfite based on an intramolecular charge transfer (ICT) mechanism. The fluorescence intensity of the decreased by 837 fold following treatment with HSO3− and detection limit was 42 nM. This showed excellent properties such as high photostability, good properties, large Stokes shifts. More importantly, this approach offers a rapid, highly selective, sensitive method to determine in buffer solutions real samples. Furthermore, successfully...
Abstract The comprehensive understanding of the mechanisms underlying interaction cells with their membrane microenvironment is great value for fundamental biological research; however, tracking biomolecules on cell surfaces high temporal and spatial resolution remains a challenge. Herein, modular strategy presented construction surface DNA‐based sensors by engineering DNA motifs synthetic cofactors. In this strategy, stimuli‐reactive organic molecule employed as cofactor motif,...
Abstract Aims The present study aims to investigate the in vitro antifungal activity and mechanism of action bamemacrolactine C (BAC), a new 24-membered macrolide compound, against Talaromyces marneffei. Methods results test drug BAC initially demonstrated through paper disk diffusion assay, followed by determination minimum inhibitory concentration value 35.29 μg ml−1 using microdilution. association revealed that combination therapy exhibited additive effects (0.5 < FICI 1.0) when...
Excessive cadmium ions in water bodies pose a severe challenge to ecology and human health, the development of metal ion sensors is imperative.
Synthetic red fluorescent protein (RFP) chromophores have emerged as valuable tools for biological imaging and therapeutic applications, but their application in the visualization of endogenous RNA G-quadruplexes (G4s) living cells has been rarely reported so far. Here, by integrating group excellent G4 dye ThT, we modulate RFP to create a novel probe DEBIT with emission. selectively recognizes structure advantage strong binding affinity, high selectivity, photostability. Using indicator,...