A5100758144- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Plant Physiology and Cultivation Studies
- Systemic Lupus Erythematosus Research
- Mitochondrial Function and Pathology
- Domain Adaptation and Few-Shot Learning
- Multimodal Machine Learning Applications
- Postharvest Quality and Shelf Life Management
- Genomics, phytochemicals, and oxidative stress
Nanjing Medical University
2022-2025
Hebei Medical University
2024-2025
Shanghai Jiao Tong University
2019-2024
Shanghai Cancer Institute
2020-2024
Nantong University
2023-2024
Second People's Hospital of NanTong
2024
Renji Hospital
2019-2024
First Affiliated Hospital of Anhui Medical University
2020-2024
Anhui Medical University
2020-2024
Beijing University of Chinese Medicine
2024
Abstract Chrysanthemum ( morifolium Ramat.) is a globally important ornamental plant with great economic, cultural, and symbolic value. However, research on chrysanthemum challenging due to its complex genetic background. Here, we report near-complete assembly annotation for C. comprising 27 pseudochromosomes (8.15 Gb; scaffold N50 of 303.69 Mb). Comparative evolutionary analyses reveal whole-genome triplication (WGT) event shared by species approximately 6 million years ago (Mya) the...
A p-NiO/n-KNbO<sub>3</sub> heterojunction photocatalyst was synthesized <italic>via</italic> a photodeposition method and for the first time applied in photocatalytic N<sub>2</sub> fixation under simulated sunlight.
Systemic lupus erythematosus (SLE), a common lethal autoimmune disease, is characterized by effector/regulatory T cells imbalance. Current therapies are either inefficient or have severe side effects. MicroRNA-125a (miR-125a) can stabilize Treg-mediated self-tolerance targeting effector programs, but it significantly downregulated in peripheral of patients with SLE. Therefore, overexpression miR-125a may therapeutic potential to treat Considering the stability and targeted delivery miRNA...
Metabolic changes are an important characteristic of vascular complications in diabetes. The accumulation lactate the microenvironment can promote VSMC calcification diabetes, although specific mechanism remains to be fully elucidated. In this study, we explored characteristics lactylation diabetic arterial and underlying molecular mechanism. We found that high-glucose calcified VSMC, overall level was significantly increased. Mass spectrometry analysis revealed significant upregulation H3...
: Platinum (II) (Pt(II))-based anticancer drugs dominate the chemotherapy field of ovarian cancer. However, patient's quality life has severely limited owing to dose-limiting toxicities and advanced disease at time diagnosis. Multifunctional tumor-targeted nanosized ultrasound contrast agents (glutathione (GSH)-sensitive platinum (IV) (Pt(IV)) prodrug-loaded phase-transitional nanoparticles, Pt(IV) NP-cRGD) were developed for precise theranostics against
Abstract Background Long non‐coding RNAs (lncRNAs) play critical regulatory roles in diverse biological processes and diseases. While a large number of lncRNAs have been identified skeletal muscles until now, their function underlying mechanisms myogenesis remain largely unclear. Methods We characterized novel functional lncRNA designated lncMGPF (lncRNA muscle growth promoting factor) using RACE, Northern blot, fluorescence situ hybridization quantitative real‐time PCR. Its was determined...
Abstract STUDY QUESTION What is the significance and mechanism of human seminal plasma extracellular vesicles (EVs) in regulating sperm functions? SUMMARY ANSWER EV increases intracellular Ca2+ concentrations [Ca2+]i via influx by activating CatSper channels, subsequently modulate motility, especially hyperactivated which attributed to both protein non-protein components EV. WHAT IS KNOWN ALREADY EVs are functional regulators function, cargoes from normal asthenozoospermic different....
// Yue Zhang 1 , Zhengkai Wei 2 Weijian Liu Jingjing Wang ,Xuexiu He Hailong Huang Jiali and Zhengtao Yang College of Animal Science Technology, Jilin Agricultural University, Changchun, People’s Republic China Department Clinical Veterinary Medicine, Jilin, Correspondence to: Yang, email: Zhang, Keywords : As2O3; melatonin; liver injury; Nrf-2; Pathology Section Received April 09, 2016 Accepted October 29, Published December 14, Abstract Melatonin has been demonstrated to have...
Significance Hematopoietic stem cells (HSCs) harbor the capacities of both self-renewal and differentiation to sustain life-long production all blood cells. However, how individual HSCs accomplish decision versus remains largely unknown. Here, we find that Uhrf1, a key epigenetic regulator DNA methylation, specifically controls this critical process. In absence undergo erythroid-biased at expense capacity, leading hematopoietic failure lethality. Mechanistically, Uhrf1 regulates HSC-division...
Paclitaxel (PTX) is a first-line chemotherapeutic agent to treat prostate cancer (PCa), but large number of patients acquired drug resistance after short-term treatment. To develop combinational therapeutics overcome PTX-resistant PCa, we established LNCaP (LNCaP/PTX) cells and found that the LNCaP/PTX exhibited epithelial–mesenchymal transition (EMT) enhanced metastasis during selection process. We revealed β-tubulin III, androgen receptor, CXCR4 expressions were significantly increased in...
Can the Cytokine-induced killer (CIK) cells in combination with immune checkpoint inhibitor further improve efficacy of chemotherapy non-small cell lung cancer (NSCLC) patients? What are adverse reactions this therapy? But these problems not clear. Therefore, we conducted a phase 1b trial to evaluate safety and autologous CIK therapy combined Sintilimab, antibody against programmed death-1, plus untreated, advanced NSCLC patients.Patients stage IIIB/IIIC/IV received platinum-based doublet...
Knowledge of the physiological and morphological evolution adaptation nonhuman primates is critical to understand hominin origins, ecology, evolution, applications in biomedicine. Particularly, limestone langurs represent a direct example adaptations challenges exploiting high calcium harsh environment. Here, we report de novo genome assembly (Tfra_2.0) male François's langur (Trachypithecus francoisi) with contig N50 16.3 Mb resequencing data 23 individuals representing five four forest...
Abstract T‐cell engagers (TCEs) represent a breakthrough in hematological malignancy treatment but are vulnerable to antigen escape and lack vaccination effect. The “immunologically cold” solid tumor presents substantial challenges due intratumor heterogeneity an immunosuppressive microenvironment (TME). Here, methoxy poly(ethylene glycol) (mPEG)‐masked CD44×PD‐L1/CD3 trispecific nanoengager loaded with the STING agonist c‐di‐AMP (CDA) (PmTriTNE@CDA) for of triple‐negative breast cancer...
Abstract Tumour cell‐derived angiogenic‐related factors and endothelial cell mobility are essential for neovascularization haematogenous metastasis of adenoid cystic carcinoma (ACC) the human salivary glands. Our previous study demonstrated that vascular growth factor (VEGF), inducible nitric oxide synthase (iNOS), nuclear kappaB (NF‐κB) staining correlated with ACC microvessel density. However, there still remains a lack direct evidence to clarify function liposaccharide‐induced NF‐κB...