A5066874159- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Epilepsy research and treatment
- Bone Metabolism and Diseases
- Advanced Polymer Synthesis and Characterization
- Bone Tissue Engineering Materials
- Biopolymer Synthesis and Applications
- Functional Brain Connectivity Studies
- Polymer crystallization and properties
- biodegradable polymer synthesis and properties
- Polymer Nanocomposites and Properties
- Dental Implant Techniques and Outcomes
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- Oral microbiology and periodontitis research
- Breast Cancer Treatment Studies
Hainan Medical University
2024-2025
Hainan General Hospital
2024-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2021-2025
Shanghai Jiao Tong University
2011-2024
Shanghai Ninth People's Hospital
2011-2024
National Clinical Research Center for Digestive Diseases
2020-2023
Stomatology Hospital
2023
Shanghai University
2022
Nanjing Medical University
2019-2022
Systemic lupus erythematosus (SLE), a common lethal autoimmune disease, is characterized by effector/regulatory T cells imbalance. Current therapies are either inefficient or have severe side effects. MicroRNA-125a (miR-125a) can stabilize Treg-mediated self-tolerance targeting effector programs, but it significantly downregulated in peripheral of patients with SLE. Therefore, overexpression miR-125a may therapeutic potential to treat Considering the stability and targeted delivery miRNA...
Abstract Rap2B, a member of GTP-binding proteins, is widely upregulated in many types tumors and promotes migration invasion human suprarenal epithelioma. However, the function Rap2B breast cancer unknown. Expression was examined cell lines normal line using Western blot analysis. Using CCK-8 proliferation assay, cycle analysis transwell we also elucidated role proliferation, invasion. Results showed that expression higher tumor cells than cells. Flow cytometry revealed elevates...
: Platinum (II) (Pt(II))-based anticancer drugs dominate the chemotherapy field of ovarian cancer. However, patient's quality life has severely limited owing to dose-limiting toxicities and advanced disease at time diagnosis. Multifunctional tumor-targeted nanosized ultrasound contrast agents (glutathione (GSH)-sensitive platinum (IV) (Pt(IV)) prodrug-loaded phase-transitional nanoparticles, Pt(IV) NP-cRGD) were developed for precise theranostics against
// Chen-Dan Zou 1, * , Wei-Ming Zhao Xiao-Na Wang 1 Qiang Li 2 Hui Huang Wan-Peng Cheng Jian-Feng Jin He Zhang Ming-Juan Wu 3 Sheng Tai Chao-Xia Xu Gao 4 Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China General Surgery, the Second Affiliated Hospital Academy Traditional Chinese Medicines, Heilongjiang Science, These authors have contributed equally to this work Correspondence to: Zou, e-mail: zouchaoxia006@126.com Gao, gaoxu_671227@163.com Keywords:...
Abstract Background This study aimed to use single-cell RNA-seq (scRNA-seq) discover marker genes in endothelial cells (ECs) and construct a prognostic model for glioblastoma multiforme (GBM) patients combination with traditional high-throughput RNA sequencing (bulk RNA-seq). Methods Bulk data was downloaded from The Cancer Genome Atlas (TCGA) China Glioma (CGGA) databases. 10x scRNA-seq GBM were obtained the Gene Expression Omnibus (GEO) database. uniform manifold approximation projection...
The objective of this study was to assess the effects maxillary sinus floor elevation with a tissue-engineered bone constructed marrow stromal cells (bMSCs) and calcium-magnesium phosphate cement (CMPC) material. calcium (Ca), magnesium (Mg), phosphorus (P) ions released from (CPC), (MPC), CMPC were detected by inductively coupled plasma atomic emission spectroscopy (ICP-AES), proliferation osteogenic differentiation bMSCs seeded on CPC, MPC, or cultured in extracts measured MTT analysis,...
In the inflamed microenvironment of peri-implantitis, limited osteogenesis on implant surface impedes well-established reosseointegration using current clinical therapies. MicroRNAs (miRNAs) function as potent molecular managers that may simultaneously regulate multiple endogenous processes such inflammation and osteogenesis. The delivery miRNAs provide a way to effectively treat some diseases. this study, we showed miR-27a was differentially downregulated in samples from canine...
Abstract Although various new biomaterials have enriched the methods for peri-implant inflammation treatment, their efficacy is still debated, and secondary operations on implant area also caused pain patients. Recently, strategies that regulate macrophage polarization to prevent or even treat peri-implantitis attracted increasing attention. Here, we prepared a laser-drilled covered with metal organic framework-miR-27a agomir nanomembrane (L-MOF-agomir) implant, which could load sustain...
Abstract Star‐shaped polypeptide/glycopolymer biohybrids composed of poly(γ‐ benzyl L ‐glutamate) and poly( D ‐gluconamidoethyl methacrylate), exhibiting controlled molecular weights low polydispersities, were synthesized by the combination ring‐opening polymerization γ‐benzyl‐ ‐glutamate N ‐carboxyanhydride direct atom transfer radical unprotected methacrylate glycomonomer. These characterized in detail means FTIR, 1 H NMR, gel permeation chromatography, differential scanning calorimetry,...
The objectives of this study are to construct a deep convolutional neural network (DCNN) model diagnose and classify meibomian gland dysfunction (MGD) based on the in vivo confocal microscope (IVCM) images evaluate performance DCNN its auxiliary significance for clinical diagnosis treatment. We extracted 6643 IVCM from three hospitals' database as training set 1661 other two test examine model. Construction was performed using DenseNet-169. results MGD classifications by ophthalmologists...
ZnO nanorods were obtained through a controllable microfluidic reaction in capillaries and used for biomarker detection after PAA modification.
mi RNA s play a number of roles in bone, including mediating the pathological effects inflammation. Here, we found that miR‐33a‐5p expression was significantly increased after TNF ‐α treatment during BMP ‐2‐induced osteogenic differentiation hBMSC s. Luciferase reporter assays and western blotting demonstrated special AT ‐rich sequence‐binding protein 2 ( SATB 2) is target miR‐33a‐5p. Moreover, show ‐2 induces by interacting with directly via ‐2– RUNX pathway. However, first decreases...
Pancreatic cancer is one of the malignancies having poorest prognosis due to late diagnoses and lack efficient treatment regimens. The identification potential miRNA-targeted gene axes could act as targets for developing novel strategies. Herein, it was assessed that miR-488 expression markedly downregulated within pancreatic carcinoma. Higher shown be linked better rates carcinoma per online data. Within two tumor cells, MIA PaCa-2 PANC-1, overexpression significantly suppressed malignant...
Peri-implantitis, which is characterized by dense inflammatory infiltrates and increased osteoclast activity, can lead to alveolar bone destruction implantation failure. miRNAs participate in the regulation of various diseases, such as periodontitis osteoporosis. Therefore, present study aimed investigate differential expression canine peri-implantitis explore functions their target genes. An miRNA sequence analysis was used identify differentially expressed peri-implantitis. Under criteria...
Smoking cessation prolongs survival and decreases mortality of patients with non‐small‐cell lung cancer ( NSCLC ). In addition, epigenetic alterations some genes are associated survival. However, potential interactions between smoking epigenetics have not been assessed. Here, we conducted an epigenome‐wide interaction analysis DNA methylation on We used a two‐stage study design to identify methylation–smoking that affect overall for early‐stage . The discovery phase contained from Harvard,...
Several models for predicting the risk of non-sentinel lymph node (NSLN) metastasis in breast cancer patients with positive sentinel nodes (SLNs) have been developed. The purpose this study was to validate and compare these Chinese patients. A total 159 SLNs treated at our institution were included. Among them, 81 (50.9%) had least one NSLN involvement. Cambridge, Mou, Mayo, Tenon, MDA, Memorial Sloan-Kettering Cancer Center (MSKCC), Ljubljana, SNUH, Turkish, Louisville, Stanford, Saidi...
Mendelian randomization (MR) can estimate the causal effect for a risk factor on complex disease using genetic variants as instrument variables (IVs). A variety of generalized MR methods have been proposed to integrate results arising from multiple IVs in order increase power. One constructs score (GS) by linear combination regression model, which was applied medical researches broadly. However, GS-based requires individual-level data, greatly limit its application clinical research. We...
At present, the treatment of triple negative breast cancer (TNBC) is a worldwide problem, urgently requiring early precise diagnosis and effective methods. In our study, we designed type tumour targeted dual-modal microbubbles, paclitaxel (PTX)-loaded RGD-lipid microbubbles (PTX@RGD-MBs), combined with ultrasonic microbubble destruction (UTMD) to precisely diagnose TNBC improve curative effect. As first-line drug, PTX, lacking specific targeting ability be effectively internalized by cells,...