A5101693340- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Advanced Glycation End Products research
- Systemic Lupus Erythematosus Research
- Peroxisome Proliferator-Activated Receptors
- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Maternal Mental Health During Pregnancy and Postpartum
- Rheumatoid Arthritis Research and Therapies
- Immune cells in cancer
- RNA regulation and disease
- Natural Antidiabetic Agents Studies
- Genital Health and Disease
- Viral Infections and Immunology Research
- Bone Metabolism and Diseases
- Urinary and Genital Oncology Studies
- MicroRNA in disease regulation
- Genetic Associations and Epidemiology
- Apelin-related biomedical research
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- interferon and immune responses
- Pancreatic function and diabetes
Shanghai Jiao Tong University
2018-2025
Shanghai Ninth People's Hospital
2025
Renji Hospital
2020-2024
Shanghai Cancer Institute
2018-2024
Jewish General Hospital
2021-2023
Jiangsu Province Blood Center
2021
Merck (Germany)
2021
State Key Laboratory of Oncogene and Related Genes
2018-2020
Third Affiliated Hospital of Southern Medical University
2020
Affiliated Hospital of Jining Medical University
2018
Systemic lupus erythematosus (SLE), a common lethal autoimmune disease, is characterized by effector/regulatory T cells imbalance. Current therapies are either inefficient or have severe side effects. MicroRNA-125a (miR-125a) can stabilize Treg-mediated self-tolerance targeting effector programs, but it significantly downregulated in peripheral of patients with SLE. Therefore, overexpression miR-125a may therapeutic potential to treat Considering the stability and targeted delivery miRNA...
( BMJ . 2020;371:m4022) Depression in pregnant and postpartum women is common rates of detection management could potentially improve with screening. Self-report depression symptom questionnaires such as the Edinburgh Postnatal Scale (EPDS) be used part a full assessment when suspected. This study individual participant data meta-analysis to assess accuracy EPDS screening whether differs by timing screen, patient age, residence.
Chemotherapy-induced activation of cell survival pathways leads to drug resistance. MicroRNAs (miRNAs) post-transcriptionally regulate gene expression in many biological pathways. Paclitaxel (PTX) is one the first-line chemotherapy drugs for ovarian cancer, and it induces epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinase (ERK) pathway that tumor proliferation, survival, invasion, MicroRNA-7 (miR-7) has ability suppress EGFR/ERK pathway. To sensitize chemotherapy,...
Transdermal drug delivery of local anesthetics using lipid nanoparticles could enhance lipophilic drugs permeation through the stratum corneum, improve diffusion to deeper skin, and exert good therapeutic effects. The purpose this study was engineer a Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS)-modified cationic nanostructured carriers (NLC) for lidocaine (LID; TPGS/LID-NLC).TPGS/LID-NLC prepared by solvent method. particle size, polydispersity index, zeta potential, entrapment...
The chronic autoimmune disease multiple sclerosis (MS) now remains incurable. Paeoniflorin (PF), which is a monoterpene glucoside obtained from Paeonia lactiflora Pall, recognized for neuroprotective and anti-inflammatory properties. However, the precise mechanism by PF regulates MS unclear. This work aims to elucidate underlying mechanisms of in EAE, well established animal model MS, discover target proteins that directly acts on. Our results revealed administration can significantly...
Background: The blood proteome is a major source of biomarkers and therapeutic targets. We conducted proteome-wide Mendelian randomization (MR) study to identify cardiometabolic protein markers for diabetic kidney disease (DKD). Methods: measured all 369 proteins in the Olink Explore 384 Cardiometabolic panel 500 patients with type 2 diabetes from 11 communities Shanghai. Protein quantitative trait loci (pQTLs) were derived by coupling genomic proteomic data. Cis-pQTLs identified used as...
Abstract Background Necroptosis is a form of regulated necrosis that involved in various autoimmune diseases. Mixed lineage kinase domain-like pseudokinase (MLKL) has been identified as key executor necroptosis; however, the significance MLKL peripheral blood mononuclear cells (PBMCs) systemic lupus erythematosus (SLE) not investigated. In this study, we aimed to determine mRNA level PBMCs and examine its relationship with clinical features serological parameters SLE. Methods Real-time...
We tested the accuracy of 2 parent-report tools, Pediatric Symptom Checklist (PSC-35) and Child Behavior (CBCL), to identify attention-deficit/hyperactivity disorder (ADHD) distinguish complex (highly comorbid) cases in an urban, largely Latino pediatric practice. Spanish- English-speaking parents children aged 6 10 years completed a PSC-35 CBCL at well visits. Those with Attention Problems Subscale (CBCL-APS) T scores ≥60 plus controls diagnostic MINI-KID (Miniature International...
Abstract Background We sought to examine the disease course of High Disease Activity Status (HDAS) patients and their different patterns in a real-world longitudinal cohort. resolution till Lupus Low State (LLDAS) has been general treatment goal, but there is limited information on this subset who achieve this. Methods All consenting Monash Cohort had at least 12 months observation were included. HDAS was defined as SLEDAI-2K ≥ 10 ever, episode period from first clinic visit until attainment...
Rheumatoid arthritis (RA) is a complex systemic autoimmune disorder that primarily involves joints, further affects the life quality of patients, and has increased mortality. The pathogenesis RA multiple pathways, resulting in some patients showing resistance to existing drugs. Salubrinal small molecule compound recently been shown exert beneficial effects on bone tissue. However, effect not clearly confirmed. Hence, we induced collagen-induced (CIA) DBA/1J mice found treatment decreased...