A5100760146- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Migraine and Headache Studies
- Flavonoids in Medical Research
- Epigenetics and DNA Methylation
- Medicinal Plant Pharmacodynamics Research
- Plant Stress Responses and Tolerance
- Neuroscience of respiration and sleep
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Botulinum Toxin and Related Neurological Disorders
- Animal Genetics and Reproduction
- Cancer-related gene regulation
- Advanced Drug Delivery Systems
- Plant nutrient uptake and metabolism
- Biochemical effects in animals
- Reproductive Biology and Fertility
- Pain Mechanisms and Treatments
- Natural Compounds in Disease Treatment
- Immune Cell Function and Interaction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Advancements in Transdermal Drug Delivery
- Optimization and Packing Problems
- Plant Gene Expression Analysis
- Functional Brain Connectivity Studies
Suzhou Research Institute
2008-2025
Jinzhou Medical University
2024
Southern Medical University Shenzhen Hospital
2024
Fujian Medical University
2024
Xi'an Jiaotong University
2023-2024
Second Affiliated Hospital of Nanjing Medical University
2024
Northeast Agricultural University
2023-2024
Shandong Agricultural University
2023-2024
ZheJiang Institute For Food and Drug Control
2016-2024
Capital Medical University
2023
Abstract Persistent infection with high-risk human papillomavirus (HR-HPV) is the primary and initiating factor for cervical cancer. With over 200 identified HPV types, including 14 types that integrate into host epithelial cell DNA, early determination of type crucial effective risk stratification management. Presently, on-site immediate testing during screening stage, known as Point Care Testing (POCT), remains immature, severely limiting scope scenarios screening. This study, guided by...
Abstract T‐cell engagers (TCEs) represent a breakthrough in hematological malignancy treatment but are vulnerable to antigen escape and lack vaccination effect. The “immunologically cold” solid tumor presents substantial challenges due intratumor heterogeneity an immunosuppressive microenvironment (TME). Here, methoxy poly(ethylene glycol) (mPEG)‐masked CD44×PD‐L1/CD3 trispecific nanoengager loaded with the STING agonist c‐di‐AMP (CDA) (PmTriTNE@CDA) for of triple‐negative breast cancer...
Abstract Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis treatment technology, abundant patients lung are still inevitably faced recurrence metastasis, contributing to death. Lymphatic metastasis first step distant an important prognostic indicator non-small cell cancer. Tumor-induced lymphangiogenesis involved in construction microenvironment, except promoting proliferation cells, it also plays crucial role individual...
Wild soybean (Glycine soja), a relative of cultivated soybean, shows high adaptability to adverse environmental conditions. We identified and characterized wild transcription factor gene, GsWRKY40, that promotes plant salt stress. GsWRKY40 was highly expressed in roots up-regulated by treatment. localized nucleus demonstrated DNA-binding activities but without transcriptional activation. Mutation overexpression altered tolerance Arabidopsis plants. To understand the molecular mechanism...
Artemisia rupestris L. has been utilized as a traditional Uygur herb for the treatment of colds and fevers. In this study, six novel compounds including three sesquiterpenoids (1–3), thiophene (4), an acetylenic spiroketal enol ether (5), chromone glycoside (6), along with 20 known (7–26), were successfully isolated from entire plant herb. The structural elucidation these new (1–6) was achieved through comprehensive application spectroscopic techniques, encompassing 1D 2D NMR experiments,...
To explore gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx) levels in the right thalamus of patients with episodic migraine (EM) chronic (CM) their effects on chronification migraine.Migraine affects approximately 1 billion people worldwide, 2.5%-3% EM progressing to CM each year. Magnetic resonance spectroscopy studies have revealed altered GABA Glx without aura, but these neurometabolic concentrations are underexplored CM.In this cross-sectional study, were recruited....
Abstract Background This study aims to investigate the correlations of asthma in children with body mass index (BMI), adiponectin, and leptin. Methods A total 122 our hospital from January 2017 February 2018 were randomly selected divided into control group (normal) observation (BMI > 28 kg/m 2 ) according BMI. BMI, leptin levels between two groups measured compared, disease grade or analyzed. Moreover, risk factors for also identified. Results Body index, level, forced vital capacity...
Background Lactiplantibacillus plantarum ( L. plantarum) is known for its probiotic properties, including antioxidant and anti-inflammatory effects. Recent studies have highlighted the role of extracellular vesicles (EVs) from prokaryotic cells in Objective This study aims to investigate effects derived a newly isolated strain (LP25 strain) their macrophage polarization. Methods The LP25 were identified through genomic sequencing, transmission electron microscopy (TEM), nanoparticle tracking...
Migraines are a common medical condition. From basic science point of view, the central mechanism for migraine and headache is largely unknown. In present study, we demonstrate that cortical excitatory transmission significantly enhanced in anterior cingulate cortex (ACC)-a brain region which critical pain perception. Biochemical studies found phosphorylation levels both NMDA receptor GluN2B AMPA GluA1 were ACC rats. Both presynaptic release glutamate postsynaptic responses receptors...
Quantitative analysis for biological single molecules in Fritillariae Thunbergii Bulbus and identification method by chemometrics was established using high‐performance liquid chromatography. Amino acids, nucleosides, nucleobases were quantitatively analyzed, 11 peaks selected species identification. A Common pattern chemometrics, then similarity analysis, principal component hierarchical cluster heatmap applied, the results indicated that ideally identified from adulterants as Cirrhosae...
Layer and broiler hens show a dramatic difference in the volume frequency of egg production. However, it is unclear whether intrinsic competency oocyte generation also different between two types chicken. All oocytes were derived from primordial germ cells (PGC) developing embryo, female PGC proliferation (mitosis) subsequent differentiation (meiosis) determine ultimate ovarian pool available for future ovulation. In this study, we systematically compared cellular phenotype gene expression...
Sodium bicarbonate stress caused by NaHCO3 is one of the most severe abiotic stresses affecting agricultural production worldwide. However, little attention has been given to molecular mechanisms underlying plant responses sodium stress. To understand phosphorylation events in signaling pathways triggered stress, TMT-labeling-based quantitative phosphoproteomic analyses were performed on soybean leaf and root tissues under 50 mM treatment. In present study, a total 7856 phosphopeptides...
In brief Oogonial stem cells in the adult ovary can generate oocytes, but they are usually quiescent. TGFB1 is key stimulating proliferation of OSC, thereby ensuring sustained reproductive potential poultry species. Abstract (OSCs) a type germ cell present ovary. They have ability to self-renew through mitosis and differentiate into oocytes meiosis. We previously identified population OSCs chicken ovary, underlying mechanisms controlling their activation were unclear. this study, we observed...
The splicing of pre-mRNA can be constitutive or alternative. resulting transcripts may play significant roles in plant development and responses to environmental changes. Wild soybean, as a wild relative cultivated has excellent traits such alkali tolerance is an ideal material for studying stress mechanisms mining resistant genes. In this study, we identified factor GsSCL30a the SR family that depends on GsSnRK1 protein kinase. Y2H BiFC assays verified interaction between GsSCL30a. vitro...
The anterior cingulate cortex (ACC) is critical for pain perception, emotion and cognition. Previous studies showed that the ACC has a complex network architecture, which can receive some projection fibers from many brain regions, including thalamus, cerebral other regions. However, there was still lack of whole-brain mapping in adult mice. In present study, we utilized rabies virus-based retrograde trans-monosynaptic tracing system to map afferents unilateral We also combined with new...
Through a case of glass plate cutting, two-dimensional cutting pattern problem rectangular blanks is discussed. The raw material cut and layout by applying the method grouping two-stage types. Here first all are divided into different groups based on certain requirement, then transformed two one-dimensional problems. constructing an integer programming model, program can be obtained step calculating in LINGO. Because here precise algorithm applied, which not time polynomial, specific...