A5089480544- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Drug Solubulity and Delivery Systems
- Microencapsulation and Drying Processes
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Ocular Surface and Contact Lens
- Antimicrobial Peptides and Activities
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Protein Interaction Studies and Fluorescence Analysis
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Advanced Neural Network Applications
- Surfactants and Colloidal Systems
- Aerosol Filtration and Electrostatic Precipitation
- Antimicrobial agents and applications
- Dendrimers and Hyperbranched Polymers
Sun Yat-sen University
2016-2025
Zhejiang Industry Polytechnic College
2024-2025
University of Electronic Science and Technology of China
2025
Shandong First Medical University
2025
Shandong Provincial Hospital
2025
Shanghai Tenth People's Hospital
2024
Tongji University
2024
Nanjing General Hospital of Nanjing Military Command
2023-2024
Henan Normal University
2022-2024
Shanghai Jiao Tong University
2024
Although certain therapeutic agents with immunogenic properties may enhance antitumor immunity, cancer cells can eliminate harmful cytoplasmic entities and escape immunosurveillance by orchestrating autophagy. Here, an ingenious in situ self-assembled nanomicelle dissolving microneedle (DMN) patch was designed for intralesional delivery of cell death-inducer (IR780) autophagy inhibitor (chloroquine, CQ) coencapsulated micelles (C/I-Mil) efficient therapy. Upon insertion into skin, the...
Due to the complex attention mechanisms and model design, most existing vision Transformers (ViTs) can not perform as efficiently convolutional neural networks (CNNs) in realistic industrial deployment scenarios, e.g. TensorRT CoreML. This poses a distinct challenge: Can visual network be designed infer fast CNNs powerful ViTs? Recent works have tried design CNN-Transformer hybrid architectures address this issue, yet overall performance of these is far away from satisfactory. To end these,...
Lung cancer with the highest mortality poses a great threat to human health. Ferroptosis therapy has recently been raised as promising strategy for lung treatment by boosting reactive species (ROS) production and lipid peroxidation (LPO) accumulation intracellularly. However, insufficient intracellular ROS level unsatisfactory drug in lesions hamper efficacy of ferroptosis therapy. Here, an inhalable biomineralized liposome LDM co-loaded dihydroartemisinin (DHA) pH-responsive calcium...
Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to site lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are different kinds (e.g., small molecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) treating various disorders, including superficial tumors, wounds, infections, inflammatory diseases, abnormal appearance. The improved by integrating advantages multiple...
Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin Xinsheng Peng,1* Yanfang Zhou,1* Ke Han,2,3 Lingzhen Qin,3 Linghui Dian,1 Ge Li,4 Xin Pan,3 Chuanbin Wu3 1Guangdong Medical University, Dongguan, 2The Second Affiliated Hospital Guangzhou 3School Pharmaceutical Sciences, Sun Yat-Sen 4Guangzhou Neworld Pharmaceuticals Co. Ltd., Guangzhou, Guangdong, People's Republic China*These authors contributed equally to this work Abstract: Phytantriol-...
Hypertrophic scar (HS) is an undesirable skin abnormality following deep burns or operations. Although intralesional multi-injection with the suspension of triamcinolone acetonide (TA) and 5-fluorouracil (5-Fu) has exhibited great promise to HS treatment in clinical, difference metabolic behavior between TA 5-Fu remarkably compromised efficacy. Besides, traditional injection pain highly dependent on skill experts, which results poor compliance. Herein, a bilayer dissolving microneedle (BMN)...
In this study, an ingenious core–shell structure microneedle (CSMN) array was designed to synergistically boost robust immune response by the intralesional codelivery of photosensitizer and indoleamine 2,3-dioxygenase (IDO) blockade. Photosensitizer indocyanine green encapsulated into chitosan nanoparticles (ICG-NPs), followed concentrating on tip shell microneedles. 1-Methyl-tryptophan loaded cross-linked poly(vinyl pyrrolidone) alcohol) gel as core. Through direct deposition ICG-NP-loaded...
High aggressiveness and recurrence of melanoma tumors require multiple systemic drug administrations, causing discomfort severe side effects to the patients. Topical treatment strategies that provide repetitively controllable precise administrations will greatly improve effects. Methods: In this study, a spatiotemporally controlled pulsatile release system, which combined dissolving microneedles (DMNs) thermal-sensitive solid lipid nanoparticles (SLNs), was constructed realize doses...
When nanoparticles were introduced into the biological media, protein corona would be formed, which endowed with new bio-identities. Thus, controlling formation is critical to in vivo therapeutic effect. Controlling particle size most feasible method during design, and influence of media pH varies disease condition quite important. The impact on bovine serum albumin (BSA) solid lipid (SLNs) was studied here. BSA SLNs increasing (120–480 nm) 6.0 7.4 investigated. Multiple techniques employed...