A5100749312- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Pancreatic and Hepatic Oncology Research
- Asthma and respiratory diseases
- Organ Transplantation Techniques and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- SARS-CoV-2 and COVID-19 Research
- Respiratory and Cough-Related Research
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Epigenetics and DNA Methylation
- Pediatric health and respiratory diseases
- Lipoproteins and Cardiovascular Health
- Genomics and Phylogenetic Studies
- Single-cell and spatial transcriptomics
- Chronic Kidney Disease and Diabetes
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Cancer-related gene regulation
- interferon and immune responses
- Venous Thromboembolism Diagnosis and Management
- Cytokine Signaling Pathways and Interactions
Florida State University
2022-2025
Lanzhou University
2011-2025
First Hospital of Lanzhou University
2011-2025
Huazhong University of Science and Technology
2024-2025
Union Hospital
2025
Zhongshan People's Hospital
2008-2024
Shenzhen University
2022-2024
Union Hospital
2024
Jiangsu University
2024
Nanjing Medical University
2024
Importance Little is known about the relationship between metabolic score for insulin resistance (METS-IR) and prognosis of hypertensive patients in China. Objective To investigate association novel non–insulin‐based METS-IR index cardiovascular composite endpoints all-cause mortality Chinese participants. Design, setting, participants This cohort study used data from China H-Type Hypertension Project, a long-term prospective consisting 14234 southern China, with baseline March to August...
Abstract The progressive decline of physiological function and the increased risk age-related diseases challenge healthy aging. Multiple anti-aging manipulations, such as senolytics, have proven beneficial for health; however, biomarkers that label in vivo senescence at systemic levels are lacking, thus hindering applications. In this study, we generate a Glb1 +/m ‒Glb1-2A-mCherry (GAC) reporter allele gene locus, which encodes lysosomal β-galactosidase—an enzyme elevated tissues old mice. A...
Abstract Intra-tumor heterogeneity (ITH) is a compounding factor for cancer prognosis and treatment. Single-cell DNA sequencing (scDNA-seq) provides cellular resolution of the variations in cell has been widely used to study progression responses drug While low coverage scDNA-seq technologies typically large number cells, accurate clustering essential effectively characterizing ITH. Existing methods are based on either single nucleotide (SNV) or copy alterations (CNA), without leveraging...
A large percentage of patients undergoing esophagogastroduodenoscopy (EGD) screening do not have esophageal varices (EV) or only small EV. We evaluated a large, international, multicenter cohort to develop novel score, termed FIB-4plus, by combining the fibrosis-4 (FIB-4) liver stiffness measurement (LSM), and spleen (SSM) identify high-risk EV (HRV) in compensated cirrhosis. This international study involved with cirrhosis from 17 Chinese hospitals one Croatian institution (NCT04546360)....
ABSTRACT Aims The renewing Baveno VII consensus proposed criteria for the diagnosis of clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease (cACLD). performance a combined model spleen stiffness measurement (SSM) by spleen‐dedicated 100 Hz (SSM@100 Hz) or conventional 50 (SSM@50 and to rule‐in rule‐out CSPH had not been well validated. This study aims compare alone cACLD. Methods international multicenter included cACLD who underwent...
Purpose: An older female predominance has been reported among chronic cough patients in Western countries, which is considered to be associated with a higher sensitivity females.However, the characteristics of Chinese remain unclear.This study aimed explore age and sex distribution as well their relationship reflex capsaicin patients.Methods: We analyzed demographic features 1,882 consecutive who attended our clinic Guangzhou, China.Cough capsaicin, was defined lowest concentration causing 5...
Abstract The establishment of patient-derived pancreatic cancer organoid culture in recent years creates an exciting opportunity for researchers to perform a wide range vitro studies on model that closely recapitulates the tumor. One outstanding question biology is causes and consequences genomic heterogeneity observed disease. However, use organoids as study variations, we need first understand degree its stability within organoids. Here, used single-cell whole-genome sequencing investigate...
This study was conducted to investigate whether a transient receptor potential ankyrin 1 (TRPA1) antagonist (HC-030031) can reduce airway inflammation and hyperresponsiveness in murine allergic rhinitis (AR) model. BALB/c mice were sensitized challenged by ovalbumin (OVA) induce AR. HC-030031 or vehicle administrated via intraperitoneal injection prior OVA challenges. Nose-scratching events, histopathologic alterations of the airways, bronchial (BHR) assessed. Differential cells...
Introduction Patients with clinically significant portal hypertension (CSPH) are recommended to be treated non-selective beta-blockers (ie, carvedilol) prevent the first hepatic decompensation event by renewing Baveno VII consensus. CSPH is defined venous pressure gradient (HVPG)≥10 mm Hg; however, HVPG measurement not widely adopted due its invasiveness. Liver stiffness (LS)≥25 kPa can used as a surrogate of HVPG≥10 Hg rule in 90% positive predicting value majority aetiologies patients. A...
Hypermethylation leading to the loss of hypermethylated in cancer-1 (HIC1) gene expression occurs many different types human cancer. HIC1 is a transcriptional repressor that directly binds promoter region NAD-dependent deacetylase sirtuin-1 (SIRT1). SIRT1 functions cell growth, anti-apoptotic, protect neurons, senescence, and regulates energy restriction. Epigenetic modification dysregulation affecting HIC1/SIRT1 axis potentially important for development malignancies. However, importance...
Abstract Background Chronic cough has an important impact on physical, social and psychological aspects. A simple effective method to assess different aspects of chronic severity is required. We aimed develop a simple, self-completed test, Cough Evaluation Test (CET), evaluate its health. Method The items preliminary CET were generated based literature review clinical practice. Items reduction was conducted by modified Delphi method. Patients with recruited complete CET, Visual Analog Scales...
Asthma is a heterogeneous disease with variable symptoms, which presents cough either as the sole or predominant symptom without wheezing. We compared clinical and pathophysiological characteristics of asthma (CPA), variant (CVA) classic (CA) in order to determine any differential phenotypic traits.In 20 clinics across China, total 2088 patients were finally recruited, including 327 CVA, 1041 CPA 720 CA patients. recorded wheezing visual analogue scale, Leicester questionnaire (LCQ) control...
To identify risk factors predictive of or associated with gastrointestinal side effects (GISE) liraglutide in patients type 2 diabetes (T2DM).T2DM treated for the first time were obtained and grouped into without GSEA GSEA. Baseline variables, including age, sex, body mass index (BMI), glycemia profiles, alanine aminotransferase, serum creatinine, thyroid hormones, oral hypoglycemic drugs history diseases, tested possible associations outcome. Significant variables entered univariate...
Abstract Background Contrast-associated acute kidney injury (CA-AKI) is an important complication in the perioperative period of coronary angiography (CAG). Dysglycemia closely associated with occurrence CA-AKI. However, association between stress hyperglycemia and CA-AKI patients undergoing CAG remains unclear. The study aims to investigate ratio (SHR) under a large real-world cohort. Methods This was retrospective observational study, were enrolled. SHR calculated by dividing random blood...
Abstract Background and Aim Gastroesophageal varices (GEV) present in compensated advanced chronic liver disease (cACLD) can develop into high‐risk (HRV). The gold standard for diagnosing GEV is esophagogastroduodenoscopy (EGD). However, EGD invasive less tolerant. This study aimed to validate radiomics signatures based on noncontrast‐enhanced computed tomography (CT) images non‐invasive diagnosis of HRV patients with cACLD. Methods multicenter trial enrolled 161 cACLD from six university...
Renal interstitial fibrosis (RIF) is a common pathological characteristic associated with end-stage renal disease. However, treatment strategies for RIF are still very limited. In this study, we reported that kaempferol, classic flavonoid, exhibited strong and widely inhibitory effect on the expression of related genes in transforming growth factor beta 1 (TGF-β1) treated NRK-52E cells. Further studies revealed kaempferol inhibited TGF-β1 induced epithelial-mesenchymal transition (EMT)...
BACKGROUND The role of bone marrow-derived mesenchymal stem cells (BM-MSCs) in liver fibrosis remains poorly understood. This study aimed to use a mouse model carbon tetrachloride (CCL₄)-induced investigate the effects BM-MSCs during hypoxia and involvement transforming growth factor beta 1 (TGF-ß1) SMADs pathway. MATERIAL AND METHODS Thirty C57BL/6 mice were randomly divided into control group (n=10), BM-MSC-treated (n=10). In group, was induced by intraperitoneal injection CCl₄....