A5040135415- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Microbial metabolism and enzyme function
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Hepatitis C virus research
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- SARS-CoV-2 and COVID-19 Research
- Analytical chemistry methods development
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Mosquito-borne diseases and control
- Cancer Cells and Metastasis
- Cancer survivorship and care
- Sarcoma Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Wnt/β-catenin signaling in development and cancer
- Natural product bioactivities and synthesis
- Advanced Glycation End Products research
Xuzhou Medical College
2024-2025
Dalian Medical University
2016-2025
First Affiliated Hospital of Dalian Medical University
2016-2025
Chinese Center For Disease Control and Prevention
2005-2025
Shanghai Traditional Chinese Medicine Hospital
2021-2024
University of Washington
2024
China Pharmaceutical University
2024
First Affiliated Hospital of Zhengzhou University
2011-2023
Anhui Provincial Children's Hospital
2023
Kunming Medical University
2021
BackgroundIn 2009, severe fever with thrombocytopenia syndrome virus (SFTSV) was identified as a novel member of the genus phlebovirus in Bunyaviridae family China. The detailed clinical features cases SFTSV infection have not been well described, and risk factors for severity among patients fatality remain to be determined. Methodology/Principal FindingsClinical laboratory 115 hospitalized during period from June 2010 December 2011 Northeast China were retrospectively reviewed. We assessed...
Dying tumor cells after irradiation could promote the proliferation of living might cause relapse and treatment failure. Our previous study showed that activated caspase-3 probably participates in repopulation. In this study, we investigated whether high mobility group box 1(HMGB1) is also involved Colorectal were irradiated. The cleaved (CC3) irradiated HMGB1 supernatant detected by Western blot. A large number colorectal (feeder cells) then co-cultured with a small luciferase-labeled...
In this study, we report the safety of coronavirus disease 2019 (COVID-19) vaccine in patients with myasthenia gravis (MG). Patients who were vaccinated against COVID-19 included. Demographics, clinical characteristics, medications, and vaccination information collected. The main observation outcome is worsening MG symptoms within 4 weeks following vaccination. A total 22 for Ten (45.5%) had ocular (OMG), 12 (55.5%) generalized (GMG). Six (27.3%) female, mean (SD) onset age was 45.4 (11.8)...
Abstract Background The co-occurrence of chronic hepatitis B (CHB) and metabolic dysfunction-associated fatty liver disease (MAFLD) has drawn considerable attention due to its impact on outcomes. This study aimed investigate the association between hepatic steatosis virus (HBV) analyzed influence virology in patients with CHB. Methods In this cross-sectional study, 272 infected HBV who were treatment-naïve or had ceased antiviral treatment for > 6 months categorized into CHB group (n =...
Increasing evidence shows that dysregulated long non-coding RNAs (lncRNAs) can serve as potential biomarkers for cancer prognosis. However, lncRNA signatures, prognostic esophageal squamous cell carcinoma (ESCC), have been seldom reported. Based on our previous transcriptome RNA sequencing analysis from 15 paired ESCC tissues and adjacent normal tissues, we selected 10 lncRNAs with high score rank characterized the expression of those lncRNAs, by qRT-PCR, in 138 samples. These patients were...
Abstract Objective Thymopentin (5TP) significantly improved typical murine premature ovarian failure (POF) symptoms induced by a high‐fat and high‐sugar (HFHS) diet. However, its effect mechanism remain unclear. Materials methods RNA‐Seq was used to detect the differentially expressed genes among each group. HFHS‐induced POF mouse model generated injected with siRNA using Poly (lactic‐co‐glycolic acid) (PLGA) as carrier. Results suggested that 5TP promoted expression of Yin Yang 2 (YY2) in...
Oxidative stress biomarkers are measurable biological indicators that reflect the balance between production of reactive oxygen species (ROS) and body's ability to neutralize them using antioxidants. Elevated oxidative is associated with a number health effects. Herein, we report development comprehensive sensitive method for quantifying four typical in human urine solid-phase extraction (SPE) conjunction ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The...
Background Mounting research suggests that insulin resistance (IR) is associated with Helicobacter pylori ( H. ) infection. The triglyceride-glucose (TyG) index has received widespread attention due to its high sensitivity in assessing IR. This study examined the association between infection and TyG index. Methods cross-sectional used data from National Health Nutrition Examination Survey (NHANES) 1999 - 2000. Participants were categorized into quartile groups (Q1–Q4) based on their...
Platycodin D (PD), a triterpenoid saponin isolated from Platycodon grandiflorum, has well-known anti-tumor effect in multiple human cancers, including gastric cancer (GC). miR-34a plays an important role the progression of GC. However, relationship between and susceptibility GC cells to PD is still unclear. The aim our research was investigate functions mediating PD.qPCR performed detect expression level survivin cells. survivin, Bcl-2, Bax, cleaved caspase-3 analyzed using Western blot....
Lysyl oxidase-like 2 (LOXL2) is key in the hepatocellular carcinoma (HCC) tumor microenvironment and metastatic niche formation. However, its effect on proliferation clinical parameters HCC require further elucidation. The present study aimed to investigate LOXL2 expression from vitro aspects. constructed LOXL2‑small interfering RNA with a lentiviral vector, investigated of using cell lines via series assays, including reverse transcription‑quantitative polymerase chain reaction, counting,...
We confirmed that oral administration of cranberry-derived exosomes attenuated murine POF by modulating the gut microbiota and decreasing ovarian granulosa cell PANoptosis.
Intestinal barrier dysfunction is not only the consequence of liver cirrhosis, but also an active participant in development cirrhosis. Previous studies showed that external administration insulin-like growth factor 1 (IGF-1) improved intestinal function However, mechanism IGF-1 on cirrhosis fully elucidated. The present study aims to investigate mechanisms improving via regulating tight junctions intestines. We used carbon tetrachloride induced cirrhotic rats effect claudin-1 and occludin...